Protein Alignment Ac78C and acy-1

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_497970.1
• Gene: acy-1 / 175622
• WormBaseID: WBGene00000068
• Length: 1253
• Species: Caenorhabditis elegans
• Alignment Length: 1422
• Identity: 367/1422 - (25%)
• Similarity: 585/1422 - (41%)
• Gaps: 378/1422 - (26%)

  Fly   307 FKQSSLERSYLTYTH---RQRQKS-LIIVNVVDFVLKIVLA-----FV--WIMRRSELGPIESDD 360
            |:.::||..|...:.   |.|.:| ||.:.||.....:.||     |:  ||:
 Worm    45 FRSATLEAQYWKCSFSQLRDRFRSGLIYIAVVIAAWTLYLALFDRTFIQHWIV------------ 97

  Fly   361 GTSMATAITWSVC-CGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYL 424
                      |:| |.|......|......:...|:..:.:||:::                 .|
 Worm    98 ----------SLCLCAIIFAMFAFTACAAQYQRFYMPTSFLCTFLI-----------------CL 135

  Fly   425 VWYILF--------------------VIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHG 469
            |..::|                    |:.:.|.::||||..|::.|.|.:
 Worm   136 VTLLIFSAENQAAFMTPVASLATSFQVVLLIYTVIPLPLYLCILIGIIYS--------------- 185

  Fly   470 EATINPECVLFQI------------FANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKK 522
                    :||:|            :...:|:..:::.|::...||...||..|::..::|..:|
 Worm   186 --------ILFEILNKNKIGLEEAGYIKLVLHAGVHLLGVHLFILTQVRQRKTFLKVGQSMLARK 242

  Fly   523 ESEKELQRTQKLLDSILPNIVNNQI---RSEMYK---GTDPTVET---------------QFNKL 566
            :.|.|.|....::.|::|..|.:::   .||:.:   ..|....|               ::.|.
 Worm   243 DLELETQFKDHMIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLAKMVPEYRKF 307

  Fly   567 YVYPMD---NVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYC 628
            ..:.|:   |||||||||.|||:::|..||.:||.:|||||.|||.:.......::..|||||||
 Worm   308 RPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYC 372

  Fly   629 VSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFD 693
            |:...    :...|||..:||.||.||.||:...:....::|||:|||:|.||||::|.|::.||
 Worm   373 VAGCP----EPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGTKRFKFD 433

  Fly   694 VWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPG---NGGCR------DNHLKMLNVKT 749
            |:||||.:||.|||.|:.||||:||||.|.|...||:|.|   :|..|      :..:|..::||
 Worm   434 VFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQVQGTERRVKPESMKT 498

  Fly   750 YLIK---------------RTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSG 799
            :.||               ..|.|..::   :...:.|....|.......|.:...::.:..|.|
 Worm   499 FFIKGRINDGVEEEVMQVQEVESLHSQK---SSKKSTLKQKWAEKLKMNHTNSYPMRAAAREGGG 560

  Fly   800 SIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSL-PNVVEGVAMDSRRI 863
            |:....|..|            .:|..:|.:..:..:.:..:|:.||.:| .|...|...|:...
 Worm   561 SLRIKLAERN------------RSTQLLPKESNSICIMEDNRKSASLQALATNNFNGSNTDTNNT 613

  Fly   864 RNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGAC-SIQNLAEAIDGKGLII 927
            .:..||.|........|      |..:|.....|:.|::.|:..|... |:..|..||.
 Worm   614 YSERGVAGSVSKKSVAG------SESNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAIS------ 666

  Fly   928 EDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEE--IDEFIEQNIQINSNK 990
                          .:.|:.  .|.|.|:   |...|.|:::.:...|  .|:....:
 Worm   667 --------------HHHNAA--SLTRFDT---DNNFDQRLAMVIGQGEGGFDKGFWNH------- 705

  Fly   991 EIRREYLNPWTLKFKDKSQEQKF------------------CQLREDM----------------- 1020
               .:.||.|||:|.:|..|:::                  .:..:|:
 Worm   706 ---HDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKDLMEQGGEKDGITGSTVNK 767

  Fly  1021 FRSNMLCVFVI---WIFMVLCQVIII---PRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCL 1079
            :|.:.:.:.:|   .||::...|.|:   |....||........||....||:      |||...
 Worm   768 YRYSGVFIDIIVATLIFVISGAVAIMSVRPFPLSLIAYFPFAAAILILTIVLI------GLPLLA 826

  Fly  1080 KTNSAKLVHQRQRRTLFICGVI-------VSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPY 1137
            :..|.:..:|...|.|.  |::       |::|::.     ||.|                 ...
 Worm   827 RKKSFQCANQWMPRHLI--GLLLIFLPIGVAICIMP-----LCQS-----------------GDC 867

  Fly  1138 SNISMTEK-EFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPP 1201
            :|:.:..: .|.....|:...|.|.   :..:..|                 .|..|:.:.|
 Worm   868 ANVILNYRLAFSYVTILAIFAHCNF---SQLAAWP-----------------KTTAAVFIGL--- 909

  Fly  1202 LPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYY 1266
                            :.::.:.|.:.::              ::||.....|.|   ||:.:..
 Worm   910 ----------------LHIAGVFYCEFNL--------------KHLVEEQDTCNV---TAIMIPP 941

  Fly  1267 LVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSR-LGMPLGV-QMLILLISFLVMVCYHARLVE 1329
            :.|.|.       ||..:       :|.|...||: .|.||.: ::|:.:|..:|:|.:.....|
 Worm   942 IRKGLN-------YTIAL-------NSTSARTLSQDFGSPLFIWELLLDVILSIVLVAFLNYQFE 992

  Fly  1330 VTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFA 1394
            ...|:.|....||.|:...|:..|...|.|:.|::|.|.    :....||..||:.|...||:||
 Worm   993 TAFRMSFFGDVQARRDTERMQIVRDQADWLLNNVIPAHA----VESLKTDTKYSENHETVGVLFA 1053

  Fly  1395 SIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRL 1459
            ||.|:.|.|.|:.:.|:..:|:|||:|.||||||:.|.|..:|||||:|..||||:|||.|..:.
 Worm  1054 SITNWNDMYEENFEGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKN 1118

  Fly  1460 RGETSEDSVCDLVEFAFAMKQKLEEINGDAFN-NFQLRVGICSGPLVSGVIGARKPVYDIWGNTV 1523
            .....| .:..:|:||.|::..|...|.|..| :|..::|:..||:.:||||..|..|||||:||
 Worm  1119 MLHPKE-HLYQMVDFALAVQHVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTV 1182

  Fly  1524 NVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKG--KGMMTTFYVHPKG 1578
            |:||||.|||...|:||.::|.|.|..| |....|..|.|||  .||.|...|..||
 Worm  1183 NIASRMYSTGVLNRIQVSQHTREYLLDR-YEFEFRDHIEVKGIDGGMDTYLLVGRKG 1238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	55/290 (19%)
		CYCc	526..729	CDD:214485	91/226 (40%)
		Guanylate_cyc	566..753	CDD:278633	90/198 (45%)
		DUF1053	929..1020	CDD:283888	17/110 (15%)
		CYCc	1353..1554	CDD:214485	89/201 (44%)
		Guanylate_cyc	1381..1576	CDD:278633	91/197 (46%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	19/135 (14%)
		CYCc	297..469	CDD:214485	82/175 (47%)
		Guanylate_cyc	317..503	CDD:278633	90/189 (48%)
		SDF	<773..982	CDD:294387	54/308 (18%)
		CYCc	1016..1215	CDD:214485	90/204 (44%)
		Guanylate_cyc	1041..1235	CDD:278633	90/195 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810