Protein Alignment Ac78C and acy-3

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1502
• Identity: 278/1502 - (18%)
• Similarity: 483/1502 - (32%)
• Gaps: 521/1502 - (34%)

  Fly   307 FKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWS 371
            |....||:|||.:.|   ..|..::.:|.|:.. ..||:     ..||.|..      ..|:..:
 Worm     3 FSSEWLEQSYLDWRH---AASARLIRIVLFITS-GSAFL-----RTLGHIPG------FYALWTA 52

  Fly   372 VCCGIANMAICF--LGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFV 434
            |...::.:.|.|  |...|..|...|....:...|.|.:.|:..           ::..|..:|.
 Worm    53 VILLLSTVTIIFHILRPARIAAFQILAGIVLLLDVAFALPGYES-----------LFPALLAVFS 106

  Fly   435 PYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPEC--VLF-------QIFANFILYT 490
            .|....||. :.:          ||..|:|       :|...|  :||       ::.|..:::.
 Worm   107 LYTFFSLPF-YAI----------LATSTLI-------SIVQTCSFLLFVEPLHTNELLAIIVVHI 153

  Fly   491 AINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSE--MYK 553
            ..|..|:|.....||..|.||:....:.|.:..:|.:..|..|||.|.||..:.||.|.:  :||
 Worm   154 WTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQSNRLNKLLSSFLPYHLINQARHQITLYK 218

  Fly   554 GTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLR 618
               |.:   :|:.|    ..||:.:..:.||..:.::.|:....::|.:|.:|.:|:|..|.|.|
 Worm   219 ---PHL---YNETY----SQVSVAYGRLVGFESVLAQCSSIDAARVLKELDSRIERLAASNGCTR 273

  Fly   619 VKLLGDCYYC-VSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMC 682
            |...|....| :...:|       .||.......:.:...|...|..|..|:::.|||.||.|..
 Worm   274 VASEGITAVCSIPGIDS-------QHATKLCRFSMELETLINSFRDATGADVSVCIGIDSGPVTA 331

  Fly   683 GVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNV 747
            ||:|..|||:||..:....|..|:|......|::|..|.:.|....|.|
 Worm   332 GVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNETRRFLGSTGEFE---------------- 380

  Fly   748 KTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGA 812
                       ..|...|.:...||           .:|...|.:
 Worm   381 -----------LEKCPIGWKLYGHL-----------PSPELFPVN-------------------- 403

  Fly   813 SIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTG 877
                                         |..||.::|..|..|
 Worm   404 -----------------------------KRFSLVTVPQAVNRV--------------------- 418

  Fly   878 GGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFK 942
                       :.|..||.                                        |.:...
 Worm   419 -----------LQSIVAMN----------------------------------------PTLKTM 432

  Fly   943 NLNSPEDGLNRADSILVDTKE-DHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKD 1006
            ..|....|....:...:..|: :|...::.|.:                            :|::
 Worm   433 GTNKKRKGEKSQEKFDMQKKKVEHSTIISTLSQ----------------------------RFRN 469

  Fly  1007 KSQEQKFCQLREDMFRSNM-LCVFVIWIFMVLCQVIIIPRCTRLI--ICLSVGTVILTFCCVLVM 1068
            ...|.::.:..:..|..:: :.:|.:.::.:. .::::|   |||  :.|.||.:.:.|..:|::
 Worm   470 PGLEAEYHKETDHWFIPSLAISIFFLVVYGIY-HMLVMP---RLITSLALIVGALTVMFFILLML 530

  Fly  1069 AEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRM 1133
                                                               ||......|:|
 Worm   531 ---------------------------------------------------YIDYFHTFSQF--- 541

  Fly  1134 VSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNL 1198
                  |:.|.....:::.|...|                           .||...:|..:
 Worm   542 ------ITRTSAGHAVSIILIIVI---------------------------LFVCGIVNTFS--- 570

  Fly  1199 TPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALK 1263
               .||.:.|                           ||   |....:..:::.:..::.|..::
 Worm   571 ---CPQPNAP---------------------------DV---CQKAHFSTYSFAMWTITTAVFVR 602

  Fly  1264 LYYLVKALMALAMVAFYTTLIMM----KFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYH 1324
            ...:..|::.:..:..|...|.:    :||..:..:.::||           ..|||.:.||..|
 Worm   603 FPSVYLAILLIISLLTYGLQIYVTRPDEFGPREFMTELDLS-----------CFLISLVSMVFLH 656

  Fly  1325 ARLVEVTSRLDFIWKEQAERELTNMKSNRA-LNDTLIKNILPDHVATYYLSDEHTDELYSKMHNL 1388
            :|..|...||||:...:...| |:||.... ||:.::.|::|.|||...:  :...:::...|..
 Worm   657 SRRCERLLRLDFLAVVKGIEE-TSMKDKLINLNNQMLLNLVPAHVAPGVI--QKAGDVWHHSHQS 718

  Fly  1389 CGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN 1453
            .|:.:.::..|      |:: |:|.|..||.:...||:.:  ..:..|||:|:....|:.|.||.
 Worm   719 VGIAYIAVSGF------DLE-GEAGINGLNYVFSHFDQAI--ANYKGVEKVKSANRFYIVAVGLL 774

  Fly  1454 HEHLRLRGETS---EDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPV 1515
            .:..:...||.   .:.:..|..|..::.|...|      |.|.:::|:..|..::.|....:|.
 Worm   775 PDAAQNVNETPWTIGELMSTLAHFIISISQFAME------NEFHVQIGVDCGSTLAFVANTDQPR 833

  Fly  1516 YDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGK----GMMTTFYVHP 1576
            |:|:|.|::.:..:        :|...:...|:....:..::...:....:    .|....|...
 Worm   834 YEIFGETLDRSRTL--------MQAAGHDTTLVSEEVFLALRPRPLRFSSQPVKVAMNLNAYELV 890

  Fly  1577 KGISESQLISPV-------RMPAGIPLAQTPNLQR----QTSHHGSFSAVVFGMLQASKRSTAIA 1630
            .|:.:..:..|.       |...|:..||..|..|    |||...|..|..|     |....:|.
 Worm   891 TGLRDVSVDIPTMPREEQERHTQGMVEAQFANQSRMYDTQTSEMASSMASSF-----SSELRSID 950

  Fly  1631 G-----------TPTGT--PSPQIRRGHR----GSTFSSVRLSQKSTTVNPVRRN---------- 1668
            |           ||...  ..||.:|.||    .|.:...|        .||.||
 Worm   951 GDAETDSDLEWITPETALMKDPQPQRSHRFVLKNSDYDPYR--------EPVHRNIRAMSAEQDY 1007

  Fly  1669 --------------------TTRVRGR-SYRQK-KSSSNNS------IVTQASSSYMPSFRRIDQ 1705
                                |:|...| |||:. :.||.||      :..:..|....|...||:
 Worm  1008 RNRRIQSGSDMSDAECGGPSTSRANSRNSYRRGWRPSSKNSLRNGFGLFRKGHSDNEQSVDGIDK 1072

  Fly  1706 IETTISK 1712
            ||...::
 Worm  1073 IEAAANR 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	60/256 (23%)
		CYCc	526..729	CDD:214485	59/205 (29%)
		Guanylate_cyc	566..753	CDD:278633	47/187 (25%)
		DUF1053	929..1020	CDD:283888	8/91 (9%)
		CYCc	1353..1554	CDD:214485	44/204 (22%)
		Guanylate_cyc	1381..1576	CDD:278633	39/201 (19%)
acy-3	NP_497765.4	TctB	26..137	CDD:284693	30/151 (20%)
		CYCc	195..378	CDD:214485	58/199 (29%)
		Nucleotidyl_cyc_III	221..382	CDD:299850	48/201 (24%)
		CYCc	696..873	CDD:214485	41/201 (20%)
		Nucleotidyl_cyc_III	711..880	CDD:299850	37/191 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810