DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gcy-35

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001252131.1	Gene:	gcy-35 / 173202	WormBaseID:	WBGene00001555	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	626	Identity:	132/626 - (21%)
Similarity:	224/626 - (35%)	Gaps:	209/626 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 PSLR----ASTTSILSNLRKKQQGGPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGN 257
            ||.|    |..|.:|....|:....|:..||.::...|:....:|...:    :|:.|....|..
Worm   120 PSFRCDVQADGTLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQ----ERKQEHLDAFVT 180

  Fly   258 SNFEH------DLESGNSL----ASIPGQSQRPLNNEMYSAFKS--------------------- 291
               ||      .:|:.||.    .|....||..|:..:|....|
Worm   181 ---EHVVFVITQIENANSTQPKSISSKADSQIDLSTGIYEISSSDFSLAFPYHICFDPDLFVEHF 242

  Fly   292 GNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAF---VWIMRRSEL 353
            ||.:|    .:..|:.:|.:.....|...|.:          |.|..:.:..:   :::.|...|
Worm   243 GNFIK----KTFPNAMRQETRVTDLLELVHPE----------VPFSYESIKYYKNSLFVFRLKGL 293

  Fly   354 GPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQG---FVGQG 415
            |.|..:......|.:                                       ::|   |:.:|
Worm   294 GDIVHNANDEAKTVL---------------------------------------LKGSMVFIDEG 319

  Fly   416 VGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGT-----ITASCHLAVITIIKLQHGEATINP 475
            .          |||::              |.|..|     |..:.||:     .:|..:.|.:
Worm   320 K----------YILYM--------------CSVNVTTVRELIERNLHLS-----DMQRHDGTRD- 354

  Fly   476 ECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEH-----KK---ESEKELQRTQ 532
                 .|..|                    ..|::.:|.::.:|.     ||   |.|.|.|:|.
Worm   355 -----VIMLN--------------------QSRMSQVELNRTLEETTKKLKKMAQELEIEKQKTD 394

  Fly   533 KLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLV 597
            :||..::|..|.:.:||.  |..|           .....:.::||.||..||.:.:..:...:|
Worm   395 ELLCELMPASVADSLRSG--KAMD-----------AKEFADCTLLFTDIVTFTNICAMCTPYDVV 446

  Fly   598 KILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQF--ESDNWKTRPDHAVCSVETGLHM-----I 655
            .:||||:.||||:...:...:|:.:||.|..|...  ..:|...|    |.::..|:.|     :
Worm   447 TLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAER----VLNISIGMLMESKLVL 507

  Fly   656 KAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEA- 719
            ..|      ||..:.:|:|:|.|.|:.||:|.|...:.::.:.|.:||.|||.||..::|:||.
Worm   508 SPI------THKPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSETG 566

  Fly   720 ---TLKCLNDAYE-VEPGNGGCRDNHLKMLNVKTYLIKRTE 756
               .||. |.:|. ::.||...|...:    :.||.::|.:
Worm   567 KLNGLKA-NPSYVFIDRGNTEIRGKGM----MYTYFLERND 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	47/302 (16%)
		CYCc	526..729	CDD:214485	62/213 (29%)
		Guanylate_cyc	566..753	CDD:278633	57/198 (29%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
gcy-35	NP_001252131.1	HNOB	3..167	CDD:285002	12/46 (26%)
		HNOBA	218..409	CDD:285003	45/298 (15%)
		CYCc	388..579	CDD:214485	63/214 (29%)
		Guanylate_cyc	415..599	CDD:278633	58/209 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910