DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	433	Identity:	107/433 - (24%)
Similarity:	178/433 - (41%)	Gaps:	115/433 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 PYAMLPL-----------PLKWC---VVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFAN 485
            |||||.|           |...|   |........| :.::|....:|.|  :.|...|     .
Mouse   779 PYAMLELTPEEVIQRVRSPPPLCRPLVSMDQAPMEC-IQLMTQCWAEHPE--LRPSMDL-----T 835

  Fly   486 FILYTAINVAGMYTKYLTDRGQRLAFIETHKAM-------------EHKKESEKELQRTQKLLDS 537
            |.|:.:||           :|::...|::...|             |..:|.|:|.|:|.:||..
Mouse   836 FDLFKSIN-----------KGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQ 889

  Fly   538 ILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILND 602
            :||..|...::    .||  :||.::       .:.|::.|:||.|||.:::.:...::|.:|||
Mouse   890 MLPPSVAEALK----MGT--SVEPEY-------FEEVTLYFSDIVGFTTISAMSEPIEVVDLLND 941

  Fly   603 LFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLH--T 665
            |:..||.|...:...:|:.:||.|...|.....|.:.   ||.......|.::.|:...|:.  .
Mouse   942 LYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQR---HAAEIANMSLDILSAVGSFRMRHMP 1003

  Fly   666 HVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEAT---LKCLNDA 727
            .|.:.:|||:|||..:.||:|.....:.::.:.|..|:.|||.|:|.|:|::.:|   |:.|:..
Mouse  1004 EVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQG 1068

  Fly   728 YEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKS 792
            :::|     ||.              ||| |:.|   |...:..|.|.:....|....|...|
Mouse  1069 FQME-----CRG--------------RTE-LKGK---GIEDTYWLVGRLGFNKPIPKPPDLQP-- 1108

  Fly   793 ISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQL 835
                              |||..|.||:     .:|.::..:|
Mouse  1109 ------------------GASNHGISLQ-----EIPPERRKKL 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	33/142 (23%)
		CYCc	526..729	CDD:214485	60/207 (29%)
		Guanylate_cyc	566..753	CDD:278633	51/191 (27%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	19/84 (23%)
		HNOBA	<854..899	CDD:400168	12/44 (27%)
		CYCc	879..1070	CDD:214485	60/206 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810