DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac78C and Gucy2c

DIOPT Version :9

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:NP_001120790.1 Gene:Gucy2c / 14917 MGIID:106903 Length:1072 Species:Mus musculus


Alignment Length:385 Identity:91/385 - (23%)
Similarity:154/385 - (40%) Gaps:92/385 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1328 VEVTSRLDFIWKEQAERE---------------LTNMKSNRALNDTLIK----------NILPDH 1367
            :||...:...|:|..|:.               |.:.:.|.:..||||:          :::.:.
Mouse   717 LEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEER 781

  Fly  1368 VATYYLSDEHTD-----------------------ELYSKMHNLCGVMFASIPNFQDF--YSEDI 1407
            ...|....:..|                       |||.::    .:.|:.|..|...  ||..:
Mouse   782 TQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEV----TIYFSDIVGFTTICKYSTPM 842

  Fly  1408 DNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLV 1472
            :    .:.:||:|...||::::.   ..|.|::|:|..|:.|:||...:.............|::
Mouse   843 E----VVDMLNDIYKSFDQIVDH---HDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDIL 900

  Fly  1473 EFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWR 1537
            .|....  :||.:.|   ....:|:|:.|||..:||:|.:.|.|.::|:|||.||||:|||...|
Mouse   901 SFIGTF--ELEHLPG---LPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLR 960

  Fly  1538 VQVPENTAELL----CSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQ 1598
            :.:..:|..:|    |...|..  |||..:||:|..||:::......|..|.||           
Mouse   961 IHMSSSTITILKRTDCQFLYEV--RGETYLKGRGTETTYWLTGMKDQEYNLPSP----------- 1012

  Fly  1599 TPNLQRQTSHHGSFSAVVFGMLQ-------ASKRSTAIAGTPTG-TPSPQIRRGHRGSTF 1650
             |.::.|......||.::...||       .|:|.|.:|....| ....|:......||:
Mouse  1013 -PTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDSTY 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831
CYCc 526..729 CDD:214485
Guanylate_cyc 566..753 CDD:278633
DUF1053 929..1020 CDD:283888
CYCc 1353..1554 CDD:214485 57/239 (24%)
Guanylate_cyc 1381..1576 CDD:278633 59/200 (30%)
Gucy2cNP_001120790.1 Periplasmic_Binding_Protein_Type_1 35..415 CDD:299141
PKc_like 480..749 CDD:304357 5/31 (16%)
STYKc 502..744 CDD:214568 5/26 (19%)
CYCc 787..978 CDD:214485 52/206 (25%)
Guanylate_cyc 814..1001 CDD:278633 60/204 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.