DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gucy2d

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	293	Identity:	87/293 - (29%)
Similarity:	146/293 - (49%)	Gaps:	38/293 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1327 LVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYY-----LSDEHTDELYSKMH 1386
            |.:.:|.|:.:.:|:.|    .::..|...|.|:..:||..||...     :..||..|:.....
Zfish   862 LEQYSSNLEDLIRERTE----ELEVERQKTDALLAQMLPKSVALALKTGKPVKPEHFAEVTLYFS 922

  Fly  1387 NLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAG 1451
            ::.|  |.:|    ...||.|:    .:.:||::...||.::   ....|.|::|:|..||.|:|
Zfish   923 DIVG--FTTI----SALSEPIE----VVDLLNDLYTHFDGII---AIHDVYKVETIGDAYMVASG 974

  Fly  1452 L-NHEHLRLRGETSEDSVCDLVEFAFAMKQK-LEEINGDAFNNFQLRVGICSGPLVSGVIGARKP 1514
            : |....|...|.:..|: |::......|.: :.::      ..::|:|:.|||:|:||:|.:.|
Zfish   975 VPNRNGTRHAAEMANMSL-DILHCIGTFKMRHMPDV------KVKIRIGLHSGPVVAGVVGLKMP 1032

  Fly  1515 VYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCS--RGYTCVKRGEIAVKGKGMMTTFY-VHP 1576
            .|.::|:|||.||||:|||..:|:.|.::|.::|.|  .||....||...:||||:..||: |..
Zfish  1033 RYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEETFWLVGR 1097

  Fly  1577 KGISESQLISPVRMPA----GIPLAQTPNLQRQ 1605
            .|..:...|.|...|.    ||.|.:.|..:||
Zfish  1098 DGFDKPLPIPPDLTPGASNHGISLDEIPTDRRQ 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	62/209 (30%)
		Guanylate_cyc	1381..1576	CDD:278633	62/199 (31%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366
		PK_GC-2D	581..849	CDD:270945
		HNOBA	<858..903	CDD:311573	12/44 (27%)
		CYCc	883..1075	CDD:214485	63/211 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910