Protein Alignment Ac78C and Adcy2

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_061516922.1
• Gene: Adcy2 / 1272602
• VectorBaseID: AGAMI1_014459
• Length: 1227
• Species: Anopheles gambiae
• Alignment Length: 1429
• Identity: 425/1429 - (29%)
• Similarity: 642/1429 - (44%)
• Gaps: 361/1429 - (25%)

  Fly   284 EMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLII----VNVVDFVLKIVLAF 344
            |.||......:...||.       :.|.|:..|..|..|.| :||.|    ::::..:..|||.
Mosquito    14 ERYSRTMQERIEDDILS-------ENSHLDDLYTRYRQRLR-RSLFITGLGISILSCITSIVLC- 69

  Fly   345 VWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANN---YLHWAAVCTWVLF 406
              .:..:.|..:....|.|       :|.|||. :|:.|    ....|:   .|.:|.:.|..:.
Mosquito    70 --ALHDAILADVALLAGAS-------TVLCGIL-VALQF----PAVMNSPLAALSFAILTTGTIG 120

  Fly   407 NIQGFVGQGVG----FADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQ 467
            .|..|||..:.    ||           :|...:.|||:.....||...:....|:....:.::.
Mosquito   121 AISTFVGTQLAPLPLFA-----------LILGVHTMLPISWPVSVVLAVLLCIVHIGYRILSQVH 174

  Fly   468 HGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQ 532
            ....|..|     |:.|..:...:.:|:.:|.:.::|.....|...|...:|.:.:.|.|.::.:
Mosquito   175 DFPPTFFP-----QLLAETVFLASASVSSLYYRIMSDAAHIDAVDGTRTGIEQRVKLECEREQQE 234

  Fly   533 KLLDSILPNIVNNQI-RSEMYKGTDP------TVETQFNKLYVYPMDNVSILFADIKGFTELASK 590
            :||.|::|..:..:: ||.|.|..|.      ..:|:|::::|...:|||||:|||..||.|:.:
Mosquito   235 QLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQTQTRFHEMHVQRHNNVSILYADIVNFTPLSEQ 299

  Fly   591 TSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMI 655
            .:|..|||.||:||.|||:||::|.|||:|:|||||||||...    .:||.||...|..||.||
Mosquito   300 LTASDLVKTLNELFGRFDQIAQENQCLRIKILGDCYYCVSGLP----VSRPHHAANCVNMGLQMI 360

  Fly   656 KAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEAT 720
            .||:.||..|..:::||||||:|:|:|||||.:||.|||||:||.:||||||||:.|||||::||
Mosquito   361 DAIRFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKAT 425

  Fly   721 LKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFG---TRSSAHLAGSVATAAP- 781
            |..|.|.:|||||.|..|:::|....::||||  ..|.:|....|   |..|.....::.|.:|
Mosquito   426 LDYLGDMFEVEPGGGASRESYLADHKIETYLI--VPPKKPPTDLGKPATADSHTPTSNIGTPSPT 488

  Fly   782 --------------PCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQP 832
                          |...|...||:..|         ..|.:|..    ||....:.|.:|.:|
Mosquito   489 TMVQITEPDQEHLLPALEPPKTPKTPRA---------PKTPDDVR----RSHASISPITIPEEQ- 539

  Fly   833 TQLL------------------QQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGG 879
            .|||                  ....|:.:.:|  |..:....:|:.         |.|..||..
Mosquito   540 EQLLPPSPANIASGGHGLLPPPSPNSKQTVQIN--PPTINEETVDND---------GTADETGEA 593

  Fly   880 GTGPCGMSTVSSPTAMMSAPLEV-----QLRPRNGA--CSIQNL---AEAIDGKGLIIEDE---- 930
            ..|.      |...:.::.|:|.     .|..|.|:  .|:|.|   ||.......|..|.
Mosquito   594 DEGE------SRKKSCLTLPVEPITTNGHLPERVGSRKLSVQGLIAFAERRKSSSSIFGDMRKMS 652

  Fly   931 -STTD-----------------------------WIPEIPFKNLNSPEDGLNRADSILVDTKEDH 965
             |..|                             |..:.||.|              :.|:|...
Mosquito   653 ISNIDCLRSPMVATPGGPLLRTRPSSKMTKYVECWGADKPFAN--------------ITDSKMAK 703

  Fly   966 RVSVAVLDEEIDEFIEQNIQINSN-----------KEIRREYLNPWTLKFKDKSQEQKFCQLRED 1019
            .:.:|.:     ..||.|:.....           ||     |.|.|:.:::.::|..|....|.
Mosquito   704 NIGLASI-----AMIESNLLPEDGYCGECKCWGPPKE-----LQPVTMWYRNTARETLFRAQPEP 758

  Fly  1020 MFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSA 1084
            .||.:::|.|::::.:.|.|:|:......:|..||...|
Mosquito   759 TFRFDLICSFILFLTIGLIQIIVFKSNVVVIGSLSATAV-------------------------- 797

  Fly  1085 KLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKL 1149
                                    |:||.|     |:                ||..|:
Mosquito   798 ------------------------ALGLFL-----YL----------------SNYQMS------ 811

  Fly  1150 NVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTN 1214
                        .:|.|.:.||..:: ..|.|         |......:|..|..|...:::
Mosquito   812 ------------NLSPPGNNGPGQVI-AASRG---------LRLAIFLITTALIASCAIFSV--- 851

  Fly  1215 GHSVSLSNLSYSDASVMQSSS-----DVEGQCAHPEYLVFTWVLCLVSLATA---LKLYYLVKAL 1271
               ::..:|..:|...:.:::     |.|.....|.||    .:|.:|||..   ||..:|||.:
Mosquito   852 ---INFDDLVIADIHFVNNTTEDIMYDDEFAPVAPVYL----YMCAISLAAVSAFLKAGFLVKGM 909

  Fly  1272 MALAMVA-----FYTTLIMMKFGS-GDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHA--RLV 1328
            :....||     .:|:.:...:|: |:|:          |||.|.|:.|:  |:....|.  |..
Mosquito   910 LMAIFVAIQSSVLWTSSLFEAYGTLGNSW----------PLGFQGLLFLL--LISAVLHTLDRQG 962

  Fly  1329 EVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEH-TDELYSKMHNLCGVM 1392
            |..:|.||:||.:.:.|...:::.|.:|..|::||||.|||.::|..|. ..|||.:.::...||
Mosquito   963 EYAARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAQHFLKKERAVQELYHESYSSVAVM 1027

  Fly  1393 FASIPNFQDFYSE-DID-NGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGL--- 1452
            ||||||:::||.| |:: .|..|:|:|||||||||:||.:|:|:.:|||||:|:|||.|:||
Mosquito  1028 FASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMIASGLRPG 1092

  Fly  1453 -------NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIG 1510
                   |:|....|  |.|.:|..|||||.|:...|::||.::|..|:||:|:..||:::||||
Mosquito  1093 KEEGATKNNELDEKR--TEEHNVVVLVEFAIALMTALDQINRESFQRFRLRIGLNHGPVIAGVIG 1155

  Fly  1511 ARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYV 1574
            |:||.||||.|||||||||||.|...||||.||||::|.:.||:|..||.|.|||||::||::|
Mosquito  1156 AQKPQYDIWSNTVNVASRMDSCGVMGRVQVTENTAKVLMAAGYSCDCRGPIHVKGKGILTTYFV 1219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	61/278 (22%)
		Guanylate_cyc	566..753	CDD:425528	104/186 (56%)
		Adcy_cons_dom	929..1021	CDD:461877	21/136 (15%)
		Guanylate_cyc	1381..1576	CDD:425528	110/206 (53%)
Adcy2	XP_061516922.1	None