Protein Alignment Ac78C and rut

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_061516643.1
• Gene: rut / 1272318
• VectorBaseID: AGAMI1_005581
• Length: 2182
• Species: Anopheles gambiae
• Alignment Length: 1550
• Identity: 454/1550 - (29%)
• Similarity: 691/1550 - (44%)
• Gaps: 367/1550 - (23%)

  Fly   307 FKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELG-----PIESDDGTSMAT 366
            |:.:.||..|..||.:.::.|      |..|:.:|:....:|....||     .:.:...|.|
Mosquito    18 FENNELESLYQRYTLKLQRFS------VTGVVALVVILCGVMGGLSLGYNQAPTLHNVFNTFM-- 74

  Fly   367 AITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGF-------VGQGVGFADREYL 424
            .:.::|..|:..        :|...:::|.:  :|..:||....|       ||.......||.:
Mosquito    75 CLLFTVVLGLLQ--------FRLIRDSHLPY--LCYGILFFTAAFCFISMPTVGIVFPVDTREVM 129

  Fly   425 ---VWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLF-QIFAN 485
               ||.|:||||:.|||:||.:....:.|.|..|.|:. :|...:..|    |.:.:.: |:.||
Mosquito   130 AEGVWQIVFVIFLSYAMMPLQIWEAALFGLILPSIHVG-LTGYNIYTG----NFQYLAYQQLAAN 189

  Fly   486 FILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSE 550
            .:::..:||||.....:.:|.||.||::|...:..:.|.|.|.::.::||.|:||..|..:::::
Mosquito   190 MVIFVGVNVAGFVVNVMMERAQRRAFLDTRNCIAARLEMEDENEKLERLLLSVLPQHVAMEMKND 254

  Fly   551 MYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNH 615
            :..    .||.||:|:|:...:|||||||||.|||.|||:.|||:||::||:||.|||::|.|||
Mosquito   255 ILS----PVEGQFHKIYIQKHENVSILFADIVGFTVLASQCSAQELVRLLNELFGRFDQLAHDNH 315

  Fly   616 CLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSV 680
            |||:|:|||||||||....    .|.|||.|:||.||.||.||..|...|.|.||||:|||||.|
Mosquito   316 CLRIKILGDCYYCVSGIPD----PRADHARCAVEMGLDMIDAIASVVEQTDVILNMRVGIHSGRV 376

  Fly   681 MCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKML 745
            :|||||.:||.||||||||.:||||||||.|||||::.|||..|...||||.|:|..||::|:..
Mosquito   377 LCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDALGGEYEVEAGHGDTRDSYLRDN 441

  Fly   746 NVKTYLI----KRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTA 806
            .:.||.|    .|.:||. ....|.||:.
Mosquito   442 EIDTYFIVPPAHRRKPLM-LNTLGVRSAL------------------------------------ 469

  Fly   807 TGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMD-SRRIRNGCG-- 868
                ||: :.|.|.:                 :...|:.:..|..:...|.:. |.....|.|
Mosquito   470 ----GAA-NRRKLSF-----------------RNVSNVVVQLLHTIKYSVPVPFSHMATGGPGSP 512

  Fly   869 ---VMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDE 930
               ..|||||.|.||.|..|.....|.:|                          .|.||.::..
Mosquito   513 YPSTSGGAGGPGAGGAGCSGGGGAGSSSA--------------------------GGGGLFLDKN 551

  Fly   931 STTDWIPE---IPFKNLNSP--EDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNK 990
            :..:.:.:   .|||..:|.  ....||                      :::|:.|.|:..|..
Mosquito   552 ARKNKVTDKFKRPFKKRHSSVYHQPTNR----------------------VNKFLSQAIEARSVD 594

  Fly   991 EIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSV 1055
            ..:..::...:|:|::|.:|:::.|..:..|.:.|.|..::.|.....|:..:||...|::....
Mosquito   595 REKSVHVKRISLQFREKEKERQYHQDFDLGFTTAMGCSLLLLILSAGLQISALPRTLILLLLFLT 659

  Fly  1056 GTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTY 1120
            ..|.::...:|::|.....:...|.          |..:|.:...|.::.:|.::|
Mosquito   660 AFVWISAILMLLLAVRLKWIFWDLS----------QSFSLRLAITIFTIVLLYSVG--------- 705

  Fly  1121 IGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVD-ITSSGPSD 1184
                                       ::||:...:.|...|..|..|   .|.|: :.|.|.|.
Mosquito   706 ---------------------------QVNVFTCLSDHPCTTNFTTKS---IPSVESLGSVGSSS 740

  Fly  1185 EFVRST--LNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYL 1247
            :.:.|.  |:....||.....|.|:|           |:|.|:.             :||.|:|:
Mosquito   741 DILMSAGELHRNEPNLWTAGQQHHQP-----------LNNYSHR-------------KCALPQYI 781

  Fly  1248 VFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGS-GDSFSLVELSRLGMPLGVQML 1311
            ..:.....:|::..|:|..|:|.::...|...|...|.:...: .|.:.  :.....:||....:
Mosquito   782 ALSAAYSFLSVSIFLRLPILIKTVLVTLMALVYCLFIELSHANIFDCYD--QRVESAIPLHTISV 844

  Fly  1312 ILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE 1376
            ..::.|::.:..|.|.||.|:||||:|:.||.:|...|...:..|..::.|:||.|||.::|.::
Mosquito   845 ARILIFMIAILAHGRQVEWTARLDFLWQLQASQEKKEMSVLQQSNRRILYNLLPSHVAAHFLDNQ 909

  Fly  1377 HT--------DELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEP 1431
            ..        .:||.:.::..||:|||:|||.:||:| |..| |..|:|:|||||.||||||.|.
Mosquito   910 FARSNMATMRQDLYHQSYSKVGVIFASVPNFHEFYTELDGSNQGVECLRLLNEIIADFDELLCEE 974

  Fly  1432 RFASVEKIKTVGATYMAAAGLNHEHLRLRGE--TSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQ 1494
            ||.:::||||||:|||||.||..||..|..|  :....:..||:|..||:..|:.||.:::|||.
Mosquito   975 RFHAIDKIKTVGSTYMAAVGLIPEHKMLPSEPGSMRRLMTALVDFVKAMRVTLKNINENSYNNFM 1039

  Fly  1495 LRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRG 1559
            ||||:..||:|:||||||||.||||||||||||||||||.....||.:...:.|....:....||
Mosquito  1040 LRVGVNVGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGIPGYTQVTQEVVDSLQGSHFEFRCRG 1104

  Fly  1560 EIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIP-------LAQTPNLQRQTSHHGSFSAVVF 1617
            :|.|||||.|.|:::..:  :|..|.:...:..|:.       .|.:...|:|.|.....|..|.
Mosquito  1105 QIKVKGKGDMVTYFLCEQ--NEQHLFAGGMVTNGLAGGGGGGGGASSVVQQQQQSVDAVGSTAVL 1167

  Fly  1618 GMLQASKRSTAIAGTPTG---------------------------------------TPSPQIRR 1643
            .|         :.||.||                                       ....|.::
Mosquito  1168 AM---------VGGTGTGESGGAMGASGNASLGRDRAGAAALHHQYMMAPNGNMAGLVQQQQQQQ 1223

  Fly  1644 GHRGSTF-SSVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSN------------------NSIV 1689
            ...||.| ...|:..::.|   .:....:..|.||..||.|.|                  ..:|
Mosquito  1224 QQLGSNFHMKQRMEMEAAT---GKNGRWQHDGGSYSSKKESYNFLESPNLLHQQQQQQQQQQQMV 1285

  Fly  1690 T-------------QASSSYMPSF---------------RRIDQIETTISKSHND 1716
            .             |||.:.|.||               ::..|::..:.|.||:
Mosquito  1286 QNQQLQMKHLHNQGQASKNSMQSFHYPQSYSNPAQAAQPQQQQQVKGGVYKQHNN 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	68/259 (26%)
		Guanylate_cyc	566..753	CDD:425528	115/190 (61%)
		Adcy_cons_dom	929..1021	CDD:461877	15/96 (16%)
		Guanylate_cyc	1381..1576	CDD:425528	106/198 (54%)
rut	XP_061516643.1	None