Protein Alignment Ac78C and ACXD

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_061503573.1
• Gene: ACXD / 1269596
• VectorBaseID: AGAMI1_009197
• Length: 1215
• Species: Anopheles gambiae
• Alignment Length: 1453
• Identity: 352/1453 - (24%)
• Similarity: 573/1453 - (39%)
• Gaps: 419/1453 - (28%)

  Fly   252 CSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFKSGNVVKGIL---CPSLTNSFKQSSLE 313
            |....|::..||.|..                  |.|.|...:  |.|   |.:|       .||
Mosquito    21 CRPDSNADQSHDTEGD------------------YIALKKWEL--GFLRRECVNL-------GLE 58

  Fly   314 RSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIAN 378
            ..||.|..|.::..|.|..|:...:.|....|.:..:..           ...||...:.|.:..
Mosquito    59 TFYLKYMERVQRSYLSIFVVLQTFVSISHVIVIVTGKPH-----------PTAAIHPDLICYLFG 112

  Fly   379 MAICFLGYWRCFANNYLH---WA-------AVCTWVLFNIQ-GFVGQGVGFADREYLVWYILFVI 432
            :.|.::..:..|....:.   |.       ||.|.::.::. ......|.|.:......|....|
Mosquito   113 ILIVWISLFAAFKEGLVKAYPWVPYVSSSIAVITMIITDLTIPLYHAVVTFINPPLRPSYASHTI 177

  Fly   433 FVPYAMLPLPLK-WCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAG 496
            ...|..|||... ..::.|:.|:.|:|.|:|:|..:..|.|      ..::....|.:..:|:.|
Mosquito   178 LAIYIFLPLTENIHGIILGSATSLCYLIVMTLITYRLEENT------ALKVITELIYFICLNLFG 236

  Fly   497 MYTKYLTDRGQRLAFIETHKAME------HKKESEKELQRTQKLLDSILP----NIVNNQIRSEM 551
            :|.:.:.:...|..|::..:.:|      ..:..|||      ||.||||    .::...||:.:
Mosquito   237 LYFRLINEVAIRRTFLDRRELVEGNLLLKFARNQEKE------LLLSILPEHTAELMEKDIRAMI 295

  Fly   552 YK------GTDPTVETQ-----------FNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKI 599
            .|      ..:.|:.||           .|||||....||:||:||:..:|.:.::...:.||.:
Mosquito   296 EKMRNDQHNANQTINTQNFFRTGTQWRSINKLYVQKHTNVTILYADVVNYTHMTTQLPVRTLVDV 360

  Fly   600 LNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLH 664
            |::||.:||..:::.:.||:|.|||||||||.....|    ..||...|..||.|||.|:|||:.
Mosquito   361 LHELFVKFDEASKEFNVLRIKFLGDCYYCVSGVPVRN----KYHAKSCVNLGLRMIKDIRDVRMS 421

  Fly   665 THVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYE 729
            ..::::|||||||||::.||:|..||.:|:||.||||||.|||.|..|:||::..||:.|:..|.
Mosquito   422 RDLNIDMRIGIHSGSIISGVIGACKWQYDIWSKDVIIANKMESTGEAGKVHVTMQTLELLDGEYI 486

  Fly   730 VEPGNGGCRDNHLKML-NVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSI 793
            .|.|....:|:.:.:. |::|:||.      |:..:..       ||..|...|.      |.|.
Mosquito   487 FEEGTPQAKDDPILVKHNIQTFLIV------PQPGYDD-------GSFFTVQEPG------PSSR 532

  Fly   794 SASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAM 858
            .:||                :..::::...::..     ...:|...::...:..|.||  .:|.
Mosquito   533 MSSG----------------VKRKTIKKERSLVT-----RNFMQNSMEQFREIMKLTNV--EMAY 574

  Fly   859 DSRRIRNGCGVMGGAGGTGGGGTGPCG----------MSTVSSPTAMMSAPLE-VQLRPRNGACS 912
            :..|:                   |.|          ..|.....:..|||.. |:..||   ||
Mosquito   575 ELERM-------------------PIGRFQFNKLFSSYKTYMQEPSHTSAPARTVENGPR---CS 617

  Fly   913 IQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEID 977
                                               |:..||.|:
Mosquito   618 -----------------------------------EEDTNRLDN--------------------- 626

  Fly   978 EFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVII 1042
                               ::|:.:.|::|..|..:.|..:.|.:.::|..|::::.::|.|::
Mosquito   627 -------------------MSPFFMCFENKRWELSYLQEPDLMLKYSVLMSFIVFVCILLIQIL- 671

  Fly  1043 IPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCML 1107
                                                   |.|..::      .::...:....:|
Mosquito   672 ---------------------------------------NDASGIY------FWLLNGLSGALLL 691

  Fly  1108 SAIGL--------VLCPSS--TYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNIT 1162
            :.|.:        |..|.|  ..:......||.:|:...:||..|:....:..:||       ||
Mosquito   692 AFIPITWFKKVWDVYTPYSIDDLLRVRKPQSRVMRIFYDFSNDIMSNFVIRTVIYL-------IT 749

  Fly  1163 ISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTL--TTNGHSVSLSNLSY 1225
            |:.        ||           |.|.:..:..|           |.|  .|:..||.:|:...
Mosquito   750 IAL--------LV-----------VCSLMYLIECN-----------YDLLEQTSTTSVPVSDNLT 784

  Fly  1226 SDASVMQSSSD--VEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIM--- 1285
            |.....|:|.|  .:..|.:|..:.....|.:......|::::|:||.:.|.:..||...|.
Mosquito   785 SLFQENQTSPDPMAKNFCTNPWSVTQCLTLAIGMAFLFLRIHFLLKAAVGLLIFFFYCWAIFDDL 849

  Fly  1286 -MKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNM 1349
             ..|.|..|.:      .|:...|..|:|::..:::..:..|..|..:|.|:.||:|..::....
Mosquito   850 YYYFDSSASMN------PGLDPKVSHLMLILFIVIIFHWIDRQSEYIARTDYNWKQQLLKQKEEA 908

  Fly  1350 KSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACI 1414
            :..:..|..|::||||.|||..|::.:..:|.|::.:....||||:|.|.:......::|.|:.:
Mosquito   909 EVTKQTNKILVENILPTHVAEIYINRQLKNEFYNEEYENVAVMFATITNMEVNTDISVENEKSVL 973

  Fly  1415 RILNEIICDFDELLEE-PRFASVEKIKTVGATYMAAAGL-------------------------- 1452
            ::||||||||||.|:. ..:..|||||..|.|||||.||
Mosquito   974 KVLNEIICDFDERLQYFDGYLKVEKIKVAGWTYMAACGLDPGRCDSSSSLSGYRSVSGMTRTSLM 1038

  Fly  1453 ----------------------------NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDA 1489
                                        |..|       |.:....:.|||..:.:.|.:.:.:.
Mosquito  1039 TNGRRSLNPRTSLEVAHKASTSTRSNSSNSRH-------SNNVTIVMAEFALELMRVLRDFSNEN 1096

  Fly  1490 FNNFQ---LRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSR 1551
            |....   |||||..|.:::||:|:.||:||||||.||:||||||||...|:||.:.:||:|.|.
Mosquito  1097 FKQTSPGLLRVGISHGKVMAGVVGSSKPLYDIWGNAVNMASRMDSTGRPGRIQVTKESAEVLQSY 1161

  Fly  1552 GYTCVKRGEIAVKGKGMMTTFYV 1574
            ||.|..||||.|||:|.:.|:::
Mosquito  1162 GYQCDYRGEIFVKGRGKIPTYFL 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	67/323 (21%)
		Guanylate_cyc	566..753	CDD:425528	82/187 (44%)
		Adcy_cons_dom	929..1021	CDD:461877	9/91 (10%)
		Guanylate_cyc	1381..1576	CDD:425528	87/252 (35%)
ACXD	XP_061503573.1	None