Protein Alignment Ac78C and Adcy8

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_061499353.1
• Gene: Adcy8 / 1269297
• VectorBaseID: AGAMI1_003825
• Length: 1504
• Species: Anopheles gambiae
• Alignment Length: 1659
• Identity: 905/1659 - (54%)
• Similarity: 1075/1659 - (64%)
• Gaps: 248/1659 - (14%)

  Fly   126 GLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPGDGAQMEDN 190
            |:.|||| |.|.:|...:..||.                        |::::||:||||||..|
Mosquito    28 GIVNPAA-TIDLDQEQPDSNGAV------------------------DITQLPRIPGDGAQAPD- 66

  Fly   191 GSGDLPPSL-----------------RASTTSILSNLRKKQQGGPLRGGVAKQTP------LRVQ 232
               |.|.:.                 |..:.|:....|...:....:|....:||      |.:.
Mosquito    67 ---DTPDTTTNDHRSKAQPVPGERGDRLRSLSLAGCERHLNEAALAKGDDPVRTPDEPGDNLEIA 128

  Fly   233 SVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIP--GQSQ----------------- 278
            :....:......|....|.|    ..:::...:.|:.|...|  |..|
Mosquito   129 NNEKQQPNGIVSPSFTIEQC----GPDYQEGGQGGDPLPPPPPGGGEQPHPGDPGAVTAGSGGNA 189

  Fly   279 ---RPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKI 340
               :|..|..|||||.|||||||||||:||||:..|||||||||:|||||||||:|||||.|||:
Mosquito   190 SHTQPHTNNTYSAFKRGNVVKGILCPSMTNSFRAPSLERSYLTYSHRQRQKSLILVNVVDLVLKV 254

  Fly   341 VLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVL 405
            |||.|||...|.:        |.....:||||||.|:|..||.||.||.||||||||||||||:|
Mosquito   255 VLASVWIGFNSGM--------TIKPHEVTWSVCCIISNFLICVLGSWRLFANNYLHWAAVCTWLL 311

  Fly   406 FNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGE 470
            .|:|||:|:|:|||:||||:||:||:|||||||||||||||::.|::||.|||.|.::.|..|.:
Mosquito   312 LNLQGFLGEGLGFAEREYLIWYVLFIIFVPYAMLPLPLKWCMIAGSMTAICHLVVTSLNKFLHDK 376

  Fly   471 ATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLL 535
               :|.|::.|:.||.:||.|||.|||||||||||||||||||||||||||:|||||.||||:||
Mosquito   377 ---DPSCIVRQMIANLLLYLAINFAGMYTKYLTDRGQRLAFIETHKAMEHKRESEKEYQRTQRLL 438

  Fly   536 DSILPNIVNNQIRSEMYKGTDPT-VETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKI 599
            |||||..|||.||.||||..:.. |:|||.|||:|.|||||||||||||||||||||||||||||
Mosquito   439 DSILPMFVNNDIRKEMYKSPEQAQVDTQFKKLYIYHMDNVSILFADIKGFTELASKTSAQQLVKI 503

  Fly   600 LNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLH 664
            |||||||||:|||||||||:|||||||||||.|:|.:||:|||||||||||||||||||||||..
Mosquito   504 LNDLFARFDKIAEDNHCLRIKLLGDCYYCVSMFDSQSWKSRPDHAVCSVETGLHMIKAIKDVRCQ 568

  Fly   665 THVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYE 729
            |:|:|:||||||||||||||||.||||||||||||:|||||||||:||||||||||||||||.||
Mosquito   569 TNVELDMRIGIHSGSVMCGVLGEKKWHFDVWSNDVVIANHMESGGVPGRVHISEATLKCLNDTYE 633

  Fly   730 VEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSS--------AHLAGSVATAAPPCATP 786
            |||||||.||:||||:|:||:||||||||||::|...|.|        |.:....:.......||
Mosquito   634 VEPGNGGSRDSHLKMMNIKTFLIKRTEPLRPRKRLMDRQSTVQFEKETAAMRAGESRFRKDSKTP 698

  Fly   787 TALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPN 851
            :.      .|.|.:..|.|||.:.|:.:                        |...|.:.|
Mosquito   699 SI------TSNSTNTTGTTATCSGGSVV------------------------QHNHNNNNN---- 729

  Fly   852 VVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNL 916
                                                                    |...|..|.
Mosquito   730 --------------------------------------------------------NTTSSNNNH 738

  Fly   917 AEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIE 981
            ......|..|.|||:||||||||||||||....|:|.|:|.. |.|...|..|....||:||.|:
Mosquito   739 ITKRTSKSTIHEDETTTDWIPEIPFKNLNECGGGVNAAESFR-DKKHTDREDVFTSTEEVDEMID 802

  Fly   982 QNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRC 1046
            |:|||||||:||:|||..|||||||.|||..||||||||||||||||||:|||:||||.:|||||
Mosquito   803 QSIQINSNKQIRQEYLYTWTLKFKDSSQEGTFCQLREDMFRSNMLCVFVVWIFIVLCQAVIIPRC 867

  Fly  1047 TRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIG 1111
            |.||:.||:.|.:||..|:|||||||.|||:.|:.:|:.|||.|.|||:|:|..|:.|.:.|::|
Mosquito   868 TILIVALSITTFLLTVGCILVMAEEFSGLPKFLQQSSSTLVHDRSRRTIFVCLTIILMSIASSMG 932

  Fly  1112 LVLCPSSTYIGTADEHSRFLRMVSP-YSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLV 1175
            |::|.........|..:     ||| ||  ...:...:|||..:|     ||:...|.|....|
Mosquito   933 LMMCDLEEVDAVPDRST-----VSPSYS--YYWQAGGQLNVNSTA-----ITLLRRAVGDALEL- 984

  Fly  1176 DITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQ 1240
                    ...:..|::....|.|..:......:..||            |...::..|
Mosquito   985 --------GALINRTVSETDANTTELVTDELLDHDETT------------STPPILHPS------ 1023

  Fly  1241 CAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGS-GDSFSLVELSRLGM 1304
            |.||||:||||||||:|||||||||||||..||:||||.|:.||::.|.. .||:.|..:...||
Mosquito  1024 CVHPEYVVFTWVLCLISLATALKLYYLVKTFMAIAMVACYSFLILLVFEKVFDSYDLQYIQASGM 1088

  Fly  1305 PLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVA 1369
            ||..||:|||..||.||.|||||||||||||||||||||:||:||:|||.|||.|||||||||||
Mosquito  1089 PLAAQMMILLGVFLTMVTYHARLVEVTSRLDFIWKEQAEKELSNMRSNRHLNDLLIKNILPDHVA 1153

  Fly  1370 TYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFA 1434
            |||||:|.|||||:|||.||||||||||||:|||||||:|||||||||||||.|||.|||||||.
Mosquito  1154 TYYLSEERTDELYAKMHELCGVMFASIPNFKDFYSEDIENGKACIRILNEIISDFDSLLEEPRFE 1218

  Fly  1435 SVEKIKTVGATYMAAAGL---NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLR 1496
            :||||||||||||||:.|   ...|:   .|..|::||||||||.||:|||:|:|.||||.||||
Mosquito  1219 TVEKIKTVGATYMAASNLCSTKKSHV---DERDEEAVCDLVEFALAMRQKLQEVNKDAFNTFQLR 1280

  Fly  1497 VGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEI 1561
            |||.||||||||||||||||||||||||||||||||||||:||||:.||.||.::|||||:|||:
Mosquito  1281 VGISSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWKVQVPDYTAALLQTKGYTCVQRGEV 1345

  Fly  1562 AVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRS 1626
            .|||||:|.|::|..|.||.|||.||..:|||:|.||||:||||||.|.|.:||||||:||||||
Mosquito  1346 NVKGKGLMLTYWVLGKNISASQLTSPALVPAGVPQAQTPSLQRQTSQHSSLAAVVFGMMQASKRS 1410

  Fly  1627 TAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRGRSYRQKK---SSSNNSI 1688
            . |..|||.||||:.|.|.||||||||||:|::.:.|||||||||||||||..||   .:|..|:
Mosquito  1411 N-INTTPTATPSPKTRFGRRGSTFSSVRLNQRAPSNNPVRRNTTRVRGRSYTMKKYPTVASPTSM 1474

  Fly  1689 VTQAS----SSYMPSFRRIDQIETTISKSHNDAL 1718
            ...|.    |.::||||::.|    .:|||...|
Mosquito  1475 TLPAEDFGVSPHIPSFRQLHQ----EAKSHQTGL 1504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	196/362 (54%)
		Guanylate_cyc	566..753	CDD:425528	163/186 (88%)
		Adcy_cons_dom	929..1021	CDD:461877	59/91 (65%)
		Guanylate_cyc	1381..1576	CDD:425528	151/197 (77%)
Adcy8	XP_061499353.1	None