DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and LRRK2

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	1363	Identity:	227/1363 - (16%)
Similarity:	417/1363 - (30%)	Gaps:	495/1363 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 VDFVLKIVLAFVWIMRRSELG-------------------PIESDDGTSMATAITWSVCCGIANM 379
            :|.:..:|...:.:|:|.|..                   |.||.:.|.....:         ||
Human   477 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKL---------NM 532

  Fly   380 AICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVG----QGVGFADREYLVWYILFVIFVPYAMLP 440
            .     ..:||.|: :|     ..||..:..|:|    |..|..       .|..::..|.|:..
Human   533 V-----KKQCFKND-IH-----KLVLAALNRFIGNPGIQKCGLK-------VISSIVHFPDALEM 579

  Fly   441 LPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDR 505
            |.|:     |.:.:..|     .:::...:..|  :|:...:..  .|.|..||       ....
Human   580 LSLE-----GAMDSVLH-----TLQMYPDDQEI--QCLGLSLIG--YLITKKNV-------FIGT 623

  Fly   506 GQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYP 570
            |..||.|........|..:|.:.:..|.:| :||                  .:...|:||.|:.
Human   624 GHLLAKILVSSLYRFKDVAEIQTKGFQTIL-AIL------------------KLSASFSKLLVHH 669

  Fly   571 MDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDC-------YYC 628
            ..::.|       |.:::|....|:..:.||.....|.::|.|::...|.|...|       ..|
Human   670 SFDLVI-------FHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVEC 727

  Fly   629 VSQFESDNWKTRPDHA----VCSVETGLHMIKAI-------KDVRLHTHVDLNMRIGIHSGSVMC 682
            :....:|..:.:...:    ||..|:...:::.:       :|||    ..|.:.||.....::.
Human   728 LLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVR----KALTISIGKGDSQIIS 788

  Fly   683 GVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNV 747
            .:|  ::...||.:|.:.:      ||.            |:.   :|||...|
Human   789 LLL--RRLALDVANNSICL------GGF------------CIG---KVEPSWLG----------- 819

  Fly   748 KTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGA 812
                     ||.|.:....|...::|.::|.........:|:.:.            ||:|:||.
Human   820 ---------PLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEG------------TASGSDGN 863

  Fly   813 SIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTG 877
            ..:....::.....:|......:..|...                :||.             |:.
Human   864 FSEDVLSKFDEWTFIPDSSMDSVFAQSDD----------------LDSE-------------GSE 899

  Fly   878 GGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFK 942
            |........:::|.......|.|:        .|| .||....:..|.|.:.|   |.:..  .:
Human   900 GSFLVKKKSNSISVGEFYRDAVLQ--------RCS-PNLQRHSNSLGPIFDHE---DLLKR--KR 950

  Fly   943 NLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDK 1007
            .:.|.:|.|.   |..:.:...|..|::.|..|                  |||:....|...
Human   951 KILSSDDSLR---SSKLQSHMRHSDSISSLASE------------------REYITSLDLSAN-- 992

  Fly  1008 SQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEF 1072
                   :||:                               |..||      ..||:.|..|..
Human   993 -------ELRD-------------------------------IDALS------QKCCISVHLEHL 1013

  Fly  1073 PGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSR-------F 1130
            ..|.          :||.               .|::....||.:...:...|.||.       :
Human  1014 EKLE----------LHQN---------------ALTSFPQQLCETLKSLTHLDLHSNKFTSFPSY 1053

  Fly  1131 LRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALT 1195
            |..:|..:|:.::..:.                      ||:.::|.|...|:.:....:.|.|:
Human  1054 LLKMSCIANLDVSRNDI----------------------GPSVVLDPTVKCPTLKQFNLSYNQLS 1096

  Fly  1196 L---NLTPPLPQSHRPYTLTTNGHSVS------------LSNLSYSDAS-----VMQSSSDVEGQ 1240
            .   |||..:.:..:   |...|:.:|            :.|||.:..|     .:::...||..
Human  1097 FVPENLTDVVEKLEQ---LILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESF 1158

  Fly  1241 CAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMP 1305
            .|...:|.                          ||.....::.::|. |.:.||.:..:.|.:|
Human  1159 SARMNFLA--------------------------AMPFLPPSMTILKL-SQNKFSCIPEAILNLP 1196

  Fly  1306 LGVQMLILLISFLVMVCYHARLVEVTSR-LDFI-----WKEQAERELTNMKSNRALNDTLIKNIL 1364
                              |.|.::::|. :.::     ||....|||....:..::.|...|..|
Human  1197 ------------------HLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYL 1243

  Fly  1365 PDHVATYYLSDEHTDELYSK---MHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFD- 1425
            ...|...:||.....|:..:   :.||..:..:.....:.|.:|.....|.....|:|:..:||
Human  1244 WSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1308

  Fly  1426 -----------ELLEEPRFASVE----KIKTVGAT---------------------YMAAAGLNH 1454
                       ..|::....:|.    |:..||.|                     ..|..|::.
Human  1309 KHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDV 1373

  Fly  1455 EH--LRLRGETSEDSVCDLVEFA-----------FAMKQKL---------EEINGDAFNN--FQL 1495
            :.  :::|.:...|.|.::.:||           |..::.|         .:...||...  |.:
Human  1374 KDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNI 1438

  Fly  1496 RVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWR-VQVPENTAELLCSRGYTCVK 1557
            :....|.|::.                  |.:.:|.:.|..| ..:.:.|.|||..||:..::
Human  1439 KARASSSPVIL------------------VGTHLDVSDEKQRKACMSKITKELLNKRGFPAIR 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	44/239 (18%)
		CYCc	526..729	CDD:214485	38/220 (17%)
		Guanylate_cyc	566..753	CDD:278633	36/204 (18%)
		DUF1053	929..1020	CDD:283888	16/90 (18%)
		CYCc	1353..1554	CDD:214485	46/265 (17%)
		Guanylate_cyc	1381..1576	CDD:278633	39/242 (16%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		115/670 (17%)
		LRR 1	983..1004		7/66 (11%)
		leucine-rich repeat	985..1012	CDD:275380	9/72 (13%)
		LRR	1012..>1286	CDD:227223	59/368 (16%)
		LRR 2	1012..1033		6/45 (13%)
		leucine-rich repeat	1013..1036	CDD:275380	6/47 (13%)
		LRR 3	1036..1057		4/20 (20%)
		leucine-rich repeat	1037..1084	CDD:275380	10/68 (15%)
		LRR 4	1059..1080		4/42 (10%)
		LRR 5	1084..1105		5/20 (25%)
		leucine-rich repeat	1085..1108	CDD:275380	5/22 (23%)
		LRR 6	1108..1129		3/23 (13%)
		leucine-rich repeat	1109..1130	CDD:275380	3/23 (13%)
		LRR 7	1130..1150		4/19 (21%)
		leucine-rich repeat	1131..1174	CDD:275380	10/68 (15%)
		LRR 8	1174..1196		5/22 (23%)
		leucine-rich repeat	1175..1197	CDD:275380	6/40 (15%)
		LRR 9	1197..1218		3/20 (15%)
		leucine-rich repeat	1198..1221	CDD:275380	4/22 (18%)
		LRR 10	1221..1241		4/19 (21%)
		leucine-rich repeat	1222..1246	CDD:275380	6/23 (26%)
		LRR 11	1246..1267		4/20 (20%)
		leucine-rich repeat	1247..1269	CDD:275380	4/21 (19%)
		LRR 12	1269..1291		4/21 (19%)
		RocCOR	1334..1507	CDD:206741	28/168 (17%)
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900