DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Npr2

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_446290.1	Gene:	Npr2 / 116564	RGDID:	620851	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	233	Identity:	70/233 - (30%)
Similarity:	117/233 - (50%)	Gaps:	33/233 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 QRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPM 571
            ::|....|...:|.|:::|       .||..|||:.|..|::    :|  .||:.:       ..
  Rat   813 EKLVEERTQAYLEEKRKAE-------ALLYQILPHSVAEQLK----RG--ETVQAE-------AF 857

  Fly   572 DNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDN 636
            |:|:|.|:||.|||.|:::::..|:|.:||||:..||.|.::....:|:.:||.|..||.....|
  Rat   858 DSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRN 922

  Fly   637 WKTRPDHAVCSVETGLHMIKAIKDVRL--HTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDV 699
            .:.   ||.......|.::.|:...|:  ..|..|.:|||:|:|.|..||:|.|...:.::.:.|
  Rat   923 GQR---HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984

  Fly   700 IIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGC 737
            ..|:.|||.|...::|:|..|...|::.        ||
  Rat   985 NTASRMESNGQALKIHVSSTTKDALDEL--------GC 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	12/43 (28%)
		CYCc	526..729	CDD:214485	63/204 (31%)
		Guanylate_cyc	566..753	CDD:278633	55/174 (32%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944
		HNOBA	<798..846	CDD:400168	11/39 (28%)
		CYCc	825..1009	CDD:214485	65/206 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900