DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy9

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	1595	Identity:	408/1595 - (25%)
Similarity:	655/1595 - (41%)	Gaps:	434/1595 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 TESCSIFGNS-NFEHDLESGNSL---ASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQ 309
            :.|||..|:| .....:..|..|   ..:|...:|..:......|.|.|:             ::
Mouse    51 SSSCSSSGDSGGLPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSMNL-------------EE 102

  Fly   310 SSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCC 374
            :.|||.: ..|.|:.:.:|..|.....:..|..|                  ..|.:.:...|..
Mouse   103 ACLERCF-PQTQRRFRYALFYVGFACLLWSIYFA------------------VHMKSKVIVMVVP 148

  Fly   375 GIANMAICFLGYW-----RCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVW-------- 426
            .:..:.:| :|::     :.:|.:|...:...|.::|.:.         ...::.||
Mouse   149 ALCFLVVC-VGFFLFTFTKLYARHYAWTSLALTLLVFALT---------LAAQFQVWTPLSGRVD 203

  Fly   427 ----------------------YILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHG 469
                                  ..:.|:.:.|.::.|||...:..|        .|.:::....|
Mouse   204 SSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLG--------VVYSVLFETFG 260

  Fly   470 EATINPEC--------VLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEK 526
            ....|.:|        :.:::.:..:|:..|:..|::...::....|..|::..:::.|.|:.|.
Mouse   261 YHFRNEDCYPSPGPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEV 325

  Fly   527 ELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQ--------------------FNKLYVYPM 571
            |....::::.|::|.|:.:.:..:..:.::.:|:..                    |....:..:
Mouse   326 EKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQI 390

  Fly   572 DNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDN 636
            :.||||||||.|||::::..||..||.:|||||.||||:.|...|.::..||||||||:...
Mouse   391 EEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCP--- 452

  Fly   637 WKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVII 701
             :.|.|||.|.:|.||.|||||:.........:|||:|:|:|:|:||:||.:::.||||||||.:
Mouse   453 -EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNL 516

  Fly   702 ANHMESGGIPGRVHISEATLKCLNDAYEVEPG------NGGCRDNHLKMLNVKTYLIKRTEPLRP 760
            ||.||..|:.|:|||||||.|.|:|.||:|.|      ......:.||  .:|||||.
Mouse   517 ANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVADQLK--GLKTYLIS------- 572

  Fly   761 KRRFGTRS-SAHLAGSVATAAPPCATPTALPKSI-----SASGSGSIGGVTATGNDGASIDGRSL 819
                |.|: .:|           |:...||....     |...||..|  ..|.:.|:..|
Mouse   573 ----GQRAKESH-----------CSCAEALLSGFEVIDDSRESSGPRG--QGTASPGSVSD---- 616

  Fly   820 EYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGV----MGGAGGTGGGG 880
                            |.|..|...:|.:.|:               ||:    ...||..||..
Mouse   617 ----------------LAQTVKTFDNLKTCPS---------------CGITFAPKSEAGAEGGTV 650

  Fly   881 TGPC------GMSTVSSPTAMMSAPLEV---------QLRPRNGACS------IQN----LAEAI 920
            ...|      .....||....:|.||..         ..:.:||..|      :.|    |.|.:
Mouse   651 QNGCQDEPKTSTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEIL 715

  Fly   921 DGKGL---IIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDT-KEDHRVSVAVLDEEIDEFIE 981
            ..||.   :..|:|..  :| :.|||:.      .:.|:..||. |||..:.        |.|.:
Mouse   716 QEKGRWAGVSLDQSAL--LP-LRFKNIR------EKTDAHFVDVIKEDSLMK--------DYFFK 763

  Fly   982 QNIQINSNKEIRREYLNPWTLKFKDKSQEQKF-CQLREDMFRSNMLCVFVIWIFMVLCQVIIIPR 1045
            ..|             |.::|.|.|:..|:.: ...:|::.:::.:..|....|..|..|.:
Mouse   764 PPI-------------NQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFL--- 812

  Fly  1046 CTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAI 1110
            .|.:.:.||:      .|.:...|...|..|..|....|.|:       |.:..:|||:.|:..:
Mouse   813 STTVFLILSI------TCFLKYGATATPPPPAALAVFGADLL-------LEVLSLIVSIRMVFFL 864

  Fly  1111 GLVLCPSSTYI----GTADEHSRFLRMVS-----PYSNISMTEKEFKLNVYLSATIHHNITISTP 1166
            ..|:..:...:    |....|.....:||     .||:|:   .||:.|::        :|:.|
Mouse   865 EDVMTCTKWLLEWIAGWLPRHCIGAILVSLPALAVYSHIT---SEFETNIH--------VTMFT- 917

  Fly  1167 ASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVM 1231
               |...||.:.                                     |..:...||    |.|
Mouse   918 ---GSAVLVAVV-------------------------------------HYCNFCQLS----SWM 938

  Fly  1232 QSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFS- 1295
            :|                       ||||.:....|:...::|..   .::::|....|..:||
Mouse   939 RS-----------------------SLATIVGAGLLLLLHISLCQ---DSSIVMSPLDSAQNFSA 977

  Fly  1296 ---------LVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKS 1351
                     |.:..|....:|.::::.....|::|.:..|..||:.||.:....:|:...|.::|
Mouse   978 QRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQS 1042

  Fly  1352 NRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRI 1416
            .|...|.|::||:|.|||    ......:.|||.|:..||:||||.||.:||.|:.:.||.|.|:
Mouse  1043 MRDQADWLLRNIIPYHVA----EQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRV 1103

  Fly  1417 LNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN----------HEHLRLRGETSEDSVCDL 1471
            |||:|.||||||.:|.:.|:|||||:|||||||:|||          .||||:           |
Mouse  1104 LNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRI-----------L 1157

  Fly  1472 VEFAFAMKQKLEEINGD-AFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGEN 1535
            .|||..|.:.:::.|.: .:.||:||||...|||.:||||..|.:|||||:|||:|||||:||..
Mouse  1158 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVE 1222

  Fly  1536 WRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPK-----GISESQL-ISP-VRMPAG 1593
            .|:||.|.:..:|...||....||.:.|||||.|.| |::||     .:.:.|| ||| :|:...
Mouse  1223 CRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT-YLYPKCTDNGVVPQHQLSISPDIRVQVD 1286

  Fly  1594 IPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQK 1658
            ..:.::|.        ...:.:|..:..:.|.|   .|:...|.:.:            .|||.|
Mouse  1287 GSIGRSPT--------DEIANLVPSVQYSDKAS---LGSDDSTQAKE------------ARLSSK 1328

  Fly  1659 STTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQAS 1693
            .:...||:.......|::.  :|.|..:..|.:||
Mouse  1329 RSWREPVKAEERFPFGKAI--EKDSCEDIGVEEAS 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	44/305 (14%)
		CYCc	526..729	CDD:214485	88/222 (40%)
		Guanylate_cyc	566..753	CDD:278633	92/192 (48%)
		DUF1053	929..1020	CDD:283888	21/92 (23%)
		CYCc	1353..1554	CDD:214485	100/211 (47%)
		Guanylate_cyc	1381..1576	CDD:278633	102/205 (50%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	18/161 (11%)
		Guanylate_cyc	385..573	CDD:306677	93/204 (46%)
		Guanylate_cyc	1069..1260	CDD:306677	101/202 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810