DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy7

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	1375	Identity:	401/1375 - (29%)
Similarity:	618/1375 - (44%)	Gaps:	347/1375 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 QSSLERSY-LTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTS--MATAITW 370
            |::|...| ||..|......|::|.....:..|.:||    ...:|...:...||:  |.|..
Mouse    18 QAALYEKYRLTSLHGPLLLLLLLVAAATCIALISIAF----SHEDLRRHQVVLGTAFLMLTLF-- 76

  Fly   371 SVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVW--------- 426
                    :|:..|.|..|....:|...|:.||....:.|.|           |:|
Mouse    77 --------VALYVLVYVECLVQRWLRALALLTWACLMVLGSV-----------LMWDSLENEAHA 122

  Fly   427 -----YILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANF 486
                 :.|||:||.||:|||..:..:|.|..:...||.|...: .:..:.:::...:..|:.||.
Mouse   123 WEQVPFFLFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVFGAV-TRAFQTSMSSTQLGLQLLANA 186

  Fly   487 ILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIR--- 548
            ::....|..|.:.|:......|..||.|.|.::.:::...|.::.:.||.|:||..::..::
Mouse   187 VILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAI 251

  Fly   549 -SEMYKGTD----PTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFD 608
             ..:.:|.|    |  :..|:.|||....|||||:|||.|||.|||..|.::||.:||:||.:||
Mouse   252 IERLKEGGDRHYMP--DNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFD 314

  Fly   609 RIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRI 673
            :||:.|.|:|:|:|||||||||...    .:.|.||...|:.||.:.:|||.||..|.||::||:
Mouse   315 QIAKANECMRIKILGDCYYCVSGLP----VSLPTHARNCVKMGLDICEAIKQVREATGVDISMRV 375

  Fly   674 GIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCR 738
            |||||:|:|||:|.:||.:||||:||.:||.||:.|:||||||:||||..|:.|||||.|:|..|
Mouse   376 GIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQR 440

  Fly   739 DNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGG 803
            |.:||.:|::|||:......:|                    ||.:...:.||          |.
Mouse   441 DPYLKEMNIRTYLVIDPRSQQP--------------------PPPSHHLSKPK----------GD 475

  Fly   804 VTATGNDGASIDGRSLEYAATIAVP-------AQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSR 861
            .|             |:..|::.|.       |.:|...|  ..::::|.:..|
Mouse   476 AT-------------LKMRASVRVTRYLESWGAARPFAHL--NHRESVSSSETP----------- 514

  Fly   862 RIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLI 926
                                       :|:.....:.||.....|...|          ..||.
Mouse   515 ---------------------------ISNGRRQKAIPLRRHRAPDRSA----------SPKGR- 541

  Fly   927 IEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKE 991
            :||:...:.:..|  :.|:|.....:::|..       |......|:                |.
Mouse   542 LEDDCDDEMLSAI--EGLSSTRPCCSKSDDF-------HTFGPIFLE----------------KG 581

  Fly   992 IRREY-LNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTR------L 1049
            ..||| |.|                  ....|.:..|..::::.::|..::::||...      |
Mouse   582 FEREYRLVP------------------IPRARYDFACASLVFVCILLVHLLVMPRMATLGVSFGL 628

  Fly  1050 IICLSVGTVILTFCCVLVMAEEFPGLPRC------LKTNSAKLVHQRQRRTLFICGVIVSMCMLS 1108
            :.|| :| ::|:||    .|.||   .||      |:..|..:..|...|.:.:...:.|:..::
Mouse   629 VACL-LG-LVLSFC----FATEF---SRCFPSRSTLQAISESVETQPLVRLVLVVLTVGSLLTVA 684

  Fly  1109 AIG--LVLCP--------------SSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATI 1157
            .|.  |.|.|              :...:||..|       :.||...|........:|:|..::
Mouse   685 IINMPLTLNPGPEQPGDNKTSPLAAQNRVGTPCE-------LLPYYTCSCILGFIACSVFLRMSL 742

  Fly  1158 HHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSN 1222
            .....:.|                     |......|..||:|....|..  :..|||  ...:.
Mouse   743 ELKAMLLT---------------------VALVAYLLLFNLSPCWHVSGN--STETNG--TQRTR 782

  Fly  1223 LSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYL---VKALMALAMVAFYTTLI 1284
            |..|||..|.|.:...|                 :..||....||   :|.::...::.||.|||
Mouse   783 LLLSDAQSMPSHTLAPG-----------------ARETAPSPSYLERDLKIMVNFYLILFYATLI 830

  Fly  1285 MMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNM 1349
            ::                                      :|.::...|||.:||::.::|....
Mouse   831 LL--------------------------------------SRQIDYYCRLDCLWKKKFKKEHEEF 857

  Fly  1350 KSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DID-NGKA 1412
            ::...:|..|::|:||.|||.:::.|:..::.|.:.::...|||||:|:|:.||:| |:: .|..
Mouse   858 ETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLE 922

  Fly  1413 CIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN----HEHLRLRGETSEDSVCDLVE 1473
            |:|:|||||.||||||.:|:|:.||||||:|:||||||||:    ||:..|  |.....:..|||
Mouse   923 CLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSAPSGHENQDL--ERKHVHIGVLVE 985

  Fly  1474 FAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRV 1538
            |:.|:..||:.||..:||:|:|||||..||:::||||||||.||||||||||||||:||||..::
Mouse   986 FSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKI 1050

  Fly  1539 QVPENTAELLCSRGYTCVKRGEIAVKGKGMMTT----FYVHP---KGISESQLISPVRMPAGIPL 1596
            ||.|.|..:|...||:|..||.|.|||||.:.|    |:::|   :|.....|:   |.|:....
Mouse  1051 QVTEETCTILQGLGYSCECRGLINVKGKGELRTYFELFFLNPSVGQGFVSGSLL---RRPSLTTD 1112

  Fly  1597 AQTPNLQRQT 1606
            :.||:...:|
Mouse  1113 SNTPSSDLKT 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	60/262 (23%)
		CYCc	526..729	CDD:214485	102/210 (49%)
		Guanylate_cyc	566..753	CDD:278633	106/186 (57%)
		DUF1053	929..1020	CDD:283888	13/91 (14%)
		CYCc	1353..1554	CDD:214485	107/206 (52%)
		Guanylate_cyc	1381..1576	CDD:278633	110/204 (54%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	44/197 (22%)
		Guanylate_cyc	272..422	CDD:306677	87/153 (57%)
		DUF1053	487..593	CDD:399378	26/199 (13%)
		Guanylate_cyc	890..1085	CDD:306677	109/196 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710