Protein Alignment Ac78C and Adcy6

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_006520366.3
• Gene: Adcy6 / 11512
• MGIID: 87917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1529
• Identity: 428/1529 - (27%)
• Similarity: 672/1529 - (43%)
• Gaps: 425/1529 - (27%)

  Fly   191 GSGDLPPSLRASTT------SILSN----------------LRKKQQGGPLRG------GVAKQT 227
            |:|::.|.|||.|.      |..||                ..|:::||.:.|      |.|:.|
Mouse     2 GTGEMAPQLRALTALPEVMGSSPSNHMVAHNHPQREASKQGWSKREKGGKMVGMKTRVVGSAQVT 66

  Fly   228 ---------------PLRVQS----------VRIVEAKRAYGPK------RRTESCSIFGNSNFE 261
                           |:...|          .::.|.|.|:|.:      |.....|.|....:.
Mouse    67 GYYGGCGHAVVLIPFPVSPPSSMSWFSGLLVPKVDERKTAWGERNGQKRPRHANRASGFCAPRYM 131

  Fly   262 HDLESGNSLASIPGQSQR-PLNNEMY--SAFKSGNVVKGILCPSL-------------------- 303
            ..|::....:..|....| |..:|.:  .|.....|..|:...:|
Mouse   132 SCLKNAEPPSPTPAAHTRCPWQDEAFIRRAGPGRGVELGLRSVALGFDDTEVTTPMGTAEVAPDT 196

  Fly   304 -----------------TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWIMRR 350
                             :..|:.:.|||.|..|..:..|.|| :::.|:..::.::|.|
Mouse   197 SPRSGPSCWHRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTF------ 255

  Fly   351 SELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLH-----WAAVCTWVLFNIQG 410
             ...|.:..  .:....:|.:....:..|.:|         |.:..     |  |.::|:..|..
Mouse   256 -HAAPAQPQ--PAYVALLTCASVLFVVLMVVC---------NRHSFRQDSMW--VVSYVVLGILA 306

  Fly   411 FVGQGVGFADREYL----VWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEA 471
            .|..|...|...:.    :|..:|.:::.|.:||:.::..|:.|...::.||  |...:|...:.
Mouse   307 AVQVGGALAANPHSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHL--ILAWQLNSSDP 369

  Fly   472 TINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLD 536
            .:     ..|:.||.:|:...|..|:.|.|..:..||.||.||...::.:...:.|.::.::||.
Mouse   370 FL-----WKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLL 429

  Fly   537 SILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILN 601
            |:||..|..:::.::....:   :..|:|:|:...||||||||||:|||.|||:.:||:||..||
Mouse   430 SVLPQHVAMEMKEDINTKKE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLN 491

  Fly   602 DLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTH 666
            :||||||::|.:|||||:|:|||||||||...    :.|.|||.|.||.|:.||:||..||..|.
Mouse   492 ELFARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVEMGVDMIEAISLVREVTG 552

  Fly   667 VDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVE 731
            |::|||:|||||.|.|||||.:||.||||||||.:|||||:||..||:||:.|||:.||..||||
Mouse   553 VNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVE 617

  Fly   732 PGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISAS 796
            ||.||.|:.:||...::|:||.
Mouse   618 PGRGGERNAYLKEQCIETFLIL------------------------------------------- 639

  Fly   797 GSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSR 861
                          |||                         |::|           |..||.::
Mouse   640 --------------GAS-------------------------QKRK-----------EEKAMLAK 654

  Fly   862 RIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLI 926
            ..|.....|.|                               |.||
Mouse   655 LQRTRANSMEG-------------------------------LMPR------------------- 669

  Fly   927 IEDESTTDWIPEIPFKNLNSP----EDGLNRADSILVDTKEDHRVSVAVL--DEEIDEFIEQNIQ 985
                    |:|:..|......    :.|::       |:.:|:|.:...|  ::|:|||:.:.|.
Mouse   670 --------WVPDRAFSRTKDSKAFRQMGID-------DSSKDNRGAQDALNPEDEVDEFLGRAID 719

  Fly   986 INSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLI 1050
            ..|..::|::::..:.|.|:.:..|:|:.:..:..|.:.:.|..:::.|:...|:::.|..| ||
Mouse   720 ARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLVFPYST-LI 783

  Fly  1051 ICLSVGTVILTFCCVLVMAEEFPG--LPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLV 1113
            :.:.....:|....||:.|....|  .|:.|:..|..:|..|...|              |:|:
Mouse   784 LGIYAAIFLLLLVTVLICAVCSCGSFFPKALQRLSRNIVRSRVHST--------------AVGI- 833

  Fly  1114 LCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDIT 1178
                         .|..|..:|..:|:              .|.:|            ||:
Mouse   834 -------------FSVLLVFISAIANM--------------FTCNH------------TPI---- 855

  Fly  1179 SSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYS---DASVMQSSSDVEGQ 1240
                      .|..|..|||||            .:..:..|..|:||   ||.:.:.::..
Mouse   856 ----------RTCAARMLNLTP------------ADVTACHLQQLNYSLGLDAPLCEGTAPT--- 895

  Fly  1241 CAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFG---------------- 1289
            |:.|||.|...:|.|  ||:::.|:......:|:..:..:|.|:::..|
Mouse   896 CSFPEYFVGNVLLSL--LASSVFLHISSIGKLAMTFILGFTYLVLLLLGPPAAIFDNYDLLLGVH 958

  Fly  1290 ----SGDSFSLVELSRLG-MPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNM 1349
                |.::|..::...:| :.|.....::|:.|.:.:..||:.||.|:||||:||.||..|...|
Mouse   959 GLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEM 1023

  Fly  1350 KSNRALNDTLIKNILPDHVATYYLSDE-HTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GK 1411
            :..:|.|..|:.||||..||.::|:.| ..||||.:......||||||.||.:||.| :.:| |.
Mouse  1024 EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGV 1088

  Fly  1412 ACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAF 1476
            .|:|:|||||.||||::.|.||..:|||||:|:|||||:|||   .....:.....:..|.::|.
Mouse  1089 ECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN---ASTYDQVGRSHITALADYAM 1150

  Fly  1477 AMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVP 1541
            .:.::::.||..:|||||:::|:..||:|:||||||||.||||||||||:|||||||...|:||.
Mouse  1151 RLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVT 1215

  Fly  1542 ENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575
            .:..::|.::||....||.:.|||||.|||::::
Mouse  1216 TDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	60/309 (19%)
		CYCc	526..729	CDD:214485	110/202 (54%)
		Guanylate_cyc	566..753	CDD:278633	114/186 (61%)
		DUF1053	929..1020	CDD:283888	19/96 (20%)
		CYCc	1353..1554	CDD:214485	99/203 (49%)
		Guanylate_cyc	1381..1576	CDD:278633	97/197 (49%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	73/400 (18%)
		Guanylate_cyc	456..640	CDD:306677	115/244 (47%)
		DUF1053	668..754	CDD:368844	21/119 (18%)
		Guanylate_cyc	1056..1250	CDD:306677	97/197 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710