Protein Alignment Ac78C and ADCY9

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1471
• Identity: 392/1471 - (26%)
• Similarity: 610/1471 - (41%)
• Gaps: 410/1471 - (27%)

  Fly   319 YTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPI--ESDDGTSMATAITWSVCCG-IANMA 380
            |.......||.:..:| |.|.:...|      ..|.|:  ..|.....|||.....|.. :.:.:
Human   168 YARHYAWTSLALTLLV-FALTLAAQF------QVLTPVSGRGDSSNLTATARPTDTCLSQVGSFS 225

  Fly   381 IC----FLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPL 441
            :|    ||.|.......||   ::|..|.:::. |...|..|.|.               |..|.
Human   226 MCIEVLFLLYTVMHLPLYL---SLCLGVAYSVL-FETFGYHFRDE---------------ACFPS 271

  Fly   442 P----LKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYL 502
            |    |.|                                   ::.:..:|:..|:..|::...:
Human   272 PGAGALHW-----------------------------------ELLSRGLLHGCIHAIGVHLFVM 301

  Fly   503 TDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQ----- 562
            :....|..|::..:::.|.|:.|.|....::::.|::|.|:.:.:..:..:.::.:|:..
Human   302 SQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSP 366

  Fly   563 ---------------FNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAE 612
                           |....:..::.||||||||.|||::::..||..||.:|||||.||||:.|
Human   367 KNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCE 431

  Fly   613 DNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHS 677
            :..|.::..||||||||:...    :.|.|||.|.:|.||.|||||:.........:|||:|:|:
Human   432 ETKCEKISTLGDCYYCVAGCP----EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHT 492

  Fly   678 GSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPG------NGG 736
            |:|:||:||.:::.||||||||.:||.||..|:.|:|||||||.|.|:|.||:|.|      ...
Human   493 GTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQS 557

  Fly   737 CRDNHLKMLNVKTYLI--KRTEPLR----------------------PKRRFGTRSSAH---LAG 774
            ...:.||  .:|||||  :|.:..|                      |:.: ||.||.:   ||.
Human   558 VVADQLK--GLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQ-GTASSGNVSDLAQ 619

  Fly   775 SVAT-----AAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQ 834
            :|.|     ..|.|.. |..||    |.:|:.||....|
Human   620 TVKTFDNLKTCPSCGI-TFAPK----SEAGAEGGAPQNG-------------------------- 653

  Fly   835 LLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAP 899
             .|.:.|.:..:.|...:...|.:.:...:            ..||..|      .:...::|.|
Human   654 -CQDEHKNSTKVTSSWLLFLSVPLLAHPPK------------ASGGPNP------KTQNGLLSPP 699

  Fly   900 LEVQLRPRNGACSIQNLAEAIDGKGL---IIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDT 961
            .|.:|     ..|..:|.|.:..||.   :..|:|..  :| :.|||:.      .:.|:..||.
Human   700 QEEKL-----TNSQTSLCEILQEKGRWAGVSLDQSAL--LP-LRFKNIR------EKTDAHFVDV 750

  Fly   962 -KEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKF-CQLREDMFRSN 1024
             |||..:.        |.|.:..|             |.::|.|.|:..|:.: ...:|::.:::
Human   751 IKEDSLMK--------DYFFKPPI-------------NQFSLNFLDQELERSYRTSYQEEVIKNS 794

  Fly  1025 MLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQ 1089
            .:..|....|..|..|.:   .|.:.:.||      |.|.:...|...|..|..|...||.|:
Human   795 PVKTFASPTFSSLLDVFL---STTVFLTLS------TTCFLKYEAATVPPPPAALAVFSAALL-- 848

  Fly  1090 RQRRTLFICGVIVSMCMLSAIGLVLCPSSTYI----GTADEHSRFLRMVS-----PYSNISMTEK 1145
                 |.:..:.||:.|:..:..|:..:...:    |....|.....:||     .||:::   .
Human   849 -----LEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVT---S 905

  Fly  1146 EFKLNVY---------LSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPP 1201
            |::.|::         |.|.:|: ......:|...:.|..:..:||        |..|.::|.|
Human   906 EYETNIHFPVFTGSAALIAVVHY-CNFCQLSSWMRSSLATVVGAGP--------LLLLYVSLCP- 960

  Fly  1202 LPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYY 1266
                                     |:||:.|..|.
Human   961 -------------------------DSSVLTSPLDA----------------------------- 971

  Fly  1267 LVKALMALAMVAFYTTLIMMKFGSG----DSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARL 1327
                              :..|.|.    :|....:|.|....:|.:::::....|::|.:..|.
Human   972 ------------------VQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNRE 1018

  Fly  1328 VEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVM 1392
            .||:.||.:....:|:...|.::|.|...|.|::||:|.|||    ......:.|||.|:..||:
Human  1019 FEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVA----EQLKVSQTYSKNHDSGGVI 1079

  Fly  1393 FASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN---- 1453
            ||||.||.:||.|:.:.||.|.|:|||:|.||||||.:|.::|:|||||:|||||||:|||
Human  1080 FASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQA 1144

  Fly  1454 ------HEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGD-AFNNFQLRVGICSGPLVSGVIGA 1511
                  .|||::           |.|||..|.:.:::.|.: .:.||:||||...|||.:||||.
Human  1145 QDGSHPQEHLQI-----------LFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGT 1198

  Fly  1512 RKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHP 1576
            .|.:|||||:|||:|||||:||...|:||.|.:..:|...||....||.:.|||||.|.| |::|
Human  1199 TKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT-YLYP 1262

  Fly  1577 K-----GISESQL-ISP-VRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPT 1634
            |     .|.:.|| ||| :|:.....:.::|.        ...:.:|..:....|.|   .|:.:
Human  1263 KCTDHRVIPQHQLSISPDIRVQVDGSIGRSPT--------DEIANLVPSVQYVDKTS---LGSDS 1316

  Fly  1635 GTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRGR 1675
            .|   |.:..|         ||.|.....||:   ...|||
Human  1317 ST---QAKDAH---------LSPKRPWKEPVK---AEERGR 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	43/242 (18%)
		Guanylate_cyc	566..753	CDD:425528	93/194 (48%)
		Adcy_cons_dom	929..1021	CDD:461877	21/93 (23%)
		Guanylate_cyc	1381..1576	CDD:425528	101/205 (49%)
ADCY9	XP_005255136.1	AcyC	167..576	CDD:441717	138/474 (29%)
		Guanylate_cyc	385..573	CDD:425528	93/193 (48%)
		Guanylate_cyc	1069..1260	CDD:425528	100/202 (50%)