DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and ADCY8

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001106.1	Gene:	ADCY8 / 114	HGNCID:	239	Length:	1251	Species:	Homo sapiens

Alignment Length:	1461	Identity:	477/1461 - (32%)
Similarity:	711/1461 - (48%)	Gaps:	378/1461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 GPKRRTES-CSIFGNSNFEHDLESGNSLASIPGQSQ-------RPLNNEMYSAFKSGNVVKGILC 300
            ||..|..| |   |...|.....||::..|..|...       .|.|::.:  ...|...:|::.
Human    95 GPGERAHSTC---GTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFF--LNGGYSYRGVIF 154

  Fly   301 PSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWI-MRRSELGPIESDDGTSM 364
            |:|.||||...|||.|..|...||:||.:::||:|.:.|:.|..:.: :..:.:.|::
Human   155 PTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLK------- 212

  Fly   365 ATAITWSVCCGIANMAICFLGYWR--CFANNYLHWAAVCTWVLFNIQ--------GFVGQGVGFA 419
              .|......|| .:.||.|...|  ..::.||.::.|.|||....|        |.:|.|:|
Human   213 --GILLGFFTGI-EVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIG-- 272

  Fly   420 DREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFA 484
                   |:||.:|..|:||||||.|.::.|..|:...: ::.::..:....:||      |:.|
Human   273 -------YVLFTLFATYSMLPLPLTWAILAGLGTSLLQV-ILQVVIPRLAVISIN------QVVA 323

  Fly   485 NFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRS 549
            ..:|:..:|.||::..||:||.||.||:||.:.:|.:...|.|.||.::|:.|:||..|..::.:
Human   324 QAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMIN 388

  Fly   550 EMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDN 614
            :|....|..::.||:::|::..:||||||||:||||.|::..|||:||::||:|||||||:|.::
Human   389 DMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEH 453

  Fly   615 HCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGS 679
            ||||:|:|||||||||...    :.|.|||.|.||.||.|||.|:.||..|..|::|||||||||
Human   454 HCLRIKILGDCYYCVSGLP----EPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGS 514

  Fly   680 VMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKM 744
            |:|||||.:||.|||||.||.|||.:||||||||:|||:|||.|||..|.||.|:|..|:..|:.
Human   515 VLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRK 579

  Fly   745 LNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGN 809
            .|::|||||:.|.
Human   580 HNIETYLIKQPED---------------------------------------------------- 592

  Fly   810 DGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPN--VVEGVAMDSRRIRNGCGVMGG 872
                                               ||.|||.  |.|.|:...||       ..|
Human   593 -----------------------------------SLLSLPEDIVKESVSSSDRR-------NSG 615

  Fly   873 AGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIP 937
            |..|.|                                                       .|.|
Human   616 ATFTEG-------------------------------------------------------SWSP 625

  Fly   938 EIPFKNLNSPED---GLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNP 999
            |:||.|:...::   .|.|....|:.......:.|....|||::.||..|.:.|..::|||::.|
Human   626 ELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKP 690

  Fly  1000 WTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVII-IPRCTRLIICLSVGTVILTFC 1063
            ::|.|||.|.|.|:.|:|:::|:||::|.|::.:|:...|.:: ..|...:.|..|:..::.:..
Human   691 FSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSAL 755

  Fly  1064 CVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHS 1128
            .::..||::..||..|            |:|   |      |.:         :.||:..
Human   756 VLITTAEDYKCLPLIL------------RKT---C------CWI---------NETYLAR----- 785

  Fly  1129 RFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNA 1193
                                 ||.:.|:|..|                         |:.:.||.
Human   786 ---------------------NVIIFASILIN-------------------------FLGAILNI 804

  Fly  1194 LTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSL 1258
            |..:....:|                |.||:::.::|.   :|:   |::|||.|||.||.:|:.
Human   805 LWCDFDKSIP----------------LKNLTFNSSAVF---TDI---CSYPEYFVFTGVLAMVTC 847

  Fly  1259 ATALKLYYLVKALMALAMVAFYTTL-------IMMKFG----SGDSFSLVELSRLGMPLGVQ--M 1310
            |..|:|..::|..:.|.|:|.|..|       :.:::.    ||:.|           ||.:  .
Human   848 AVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDF-----------LGTKEVS 901

  Fly  1311 LILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL-S 1374
            |:|:..||:.|.||.:.:|.|:||||:|:.||:.|:..||..|..|:.:::||||.|||.::| .
Human   902 LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEK 966

  Fly  1375 DEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVE 1437
            |...:||||:.::..||||||||.|.||||: :::| |..|:|:|||||.||||||.|.||..:|
Human   967 DRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIE 1031

  Fly  1438 KIKTVGATYMAAAGLNHEHLRLRGETSEDS---VCDLVEFAFAMKQKLEEINGDAFNNFQLRVGI 1499
            ||||:|:||||.:||:.|.     :..||.   :|.|.:|:.|:.:.::|||..:||||:||:||
Human  1032 KIKTIGSTYMAVSGLSPEK-----QQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGI 1091

  Fly  1500 CSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVK 1564
            ..|.:|:|||||:||.|||||.|||:||||||||.:.|:||||.|..:|..:|:....||||.||
Human  1092 SHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVK 1156

  Fly  1565 G----KGMMTTFYVHPKGISESQLISPVRMPAGIPLA-------QTPNLQRQTSHHGSFSAVVFG 1618
            |    :|.:.|:::..:......::.|.|:|....||       |:.|.|||..
Human  1157 GISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQ----------- 1210

  Fly  1619 MLQASKRSTAIAG--------TPTGT-PSPQ 1640
            :|..:..:..|.|        :|:|| |..|
Human  1211 LLNENNNTGIIKGHYNRRTLLSPSGTEPGAQ 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	83/273 (30%)
		CYCc	526..729	CDD:214485	116/202 (57%)
		Guanylate_cyc	566..753	CDD:278633	115/186 (62%)
		DUF1053	929..1020	CDD:283888	30/93 (32%)
		CYCc	1353..1554	CDD:214485	109/206 (53%)
		Guanylate_cyc	1381..1576	CDD:278633	106/203 (52%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..182		29/91 (32%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..109		6/16 (38%)
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..92
		AC_N	<161..400	CDD:292831	79/264 (30%)
		CYCc	366..564	CDD:214485	116/201 (58%)
		Guanylate_cyc	405..589	CDD:278633	116/187 (62%)
		DUF1053	617..711	CDD:283888	32/148 (22%)
		CYCc	944..1148	CDD:214485	109/208 (52%)
		Guanylate_cyc	973..1172	CDD:278633	106/203 (52%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1109..1251		50/144 (35%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1200..1215		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1251		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5177
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37443
Inparanoid	1	1.050	758	1.000	Inparanoid score	I555
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107368at2759
OrthoFinder	1	1.000	-	-		FOG0006020
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830