DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	967	Identity:	207/967 - (21%)
Similarity:	331/967 - (34%)	Gaps:	290/967 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EERICLRTAEEGQLAN------------------------MDDD---KLVSDEVHLRQLSATPSS 46
            |:.:.||.|.:..|.:                        :|||   :...|.|....|..:|.|
  Rat   270 EQTVLLRCARKEGLTDGRLVFLPYDTLLFALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPES 334

  Fly    47 -AFSLQHSRGSDT----KEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVD---------KGAI 97
             ||:....||...    .|:..|..||:            .|..::|..|::         .||.
  Rat   335 HAFTATKMRGGTAANLGPEQVSPLFGTI------------YDAVILLAHALNHSEAHGTGLSGAH 387

  Fly    98 ALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQ 162
            ....|..|.:.|      ......:||.|...|.....|     .||.|:....:...|.::.:.
  Rat   388 LGNHIRALDVAG------FSQRIRIDGKGRRLPQYVILD-----TNGEGSQLVPTHILDVSTQQV 441

  Fly   163 DAASTAMATPDMSKIPRLPGDGAQMED------NGSGDLPPSLRASTTSILSNLRKKQQGGPLRG 221
            ....||:..|..|...|   |.:...|      .|...|...|..:.|.:|:          |.|
  Rat   442 QPLGTAVHFPGGSPPAR---DASCWFDPNTLCIRGVQPLGSLLTLTITCVLA----------LVG 493

  Fly   222 G-VAKQTPLRVQSVRIVEAKRAY------------GPKRR-------TESCSIFGNSN------- 259
            | :|....|.:|.:|::......            .|.||       :||.|:....:
  Rat   494 GFLAYFIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQG 558

  Fly   260 --------FEH--------------DLESG-------NSLASIPGQSQRPLNNEMYSAFKS---- 291
                    .||              ..|:|       :||:.:  :..|.:.:|..:||..
  Rat   559 STRSVPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLL--RKMREMRHENVTAFLGLFVG 621

  Fly   292 --------GNVVKGILCPSLTN-------SFKQS---SLERSYLTYTHRQ-----RQKSLIIVNV 333
                    .:..:|.|...|.|       :||.|   .|.|. |.|.|.:     |.||...|..
  Rat   622 PEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRG-LRYLHHRHFPHGRLKSRNCVVD 685

  Fly   334 VDFVLKIV-----------LAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYW 387
            ..|||||.           .:|     |.:..|.|          :.|:
  Rat   686 TRFVLKITDHGYAEFLESHCSF-----RPQPAPEE----------LLWT---------------- 719

  Fly   388 RCFANNYLH-----WA---AVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLK 444
               |...|.     |.   |.....:|:: |.:.|.|...|..|..|.:.....:.....|.||
  Rat   720 ---APELLRGPRRPWGPGKATFKGDVFSL-GIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPL- 779

  Fly   445 WCVVGGTITASCH---------LAVITIIKLQHGEATINPECVLFQIFANFILYTAIN------V 494
                       |.         |..|.:::|...||. :....|.||:..|   .:||      |
  Rat   780 -----------CRPLVSPDQGPLECIQLMQLCWEEAP-DDRPSLDQIYTQF---KSINQGKKTSV 829

  Fly   495 AGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTV 559
            |....:.|....|.|..:    ..|..:|.|.|.::|::||..:||..|.:.::    .||  ||
  Rat   830 ADSMLRMLEKYSQSLEGL----VQERTEELELERRKTERLLSQMLPPSVAHALK----MGT--TV 884

  Fly   560 ETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGD 624
            |.::       .|.|:|.|:||.|||.:::.:...::|..||||:..||.:.:.:...:|:.:||
  Rat   885 EPEY-------FDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGD 942

  Fly   625 CYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLH--THVDLNMRIGIHSGSVMCGVLGN 687
            .|...|.....|...   ||.......|.::....:.|:.  ..|.:.:|.|:|||..:.||:|.
  Rat   943 AYMVASGLPRRNGNR---HAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGL 1004

  Fly   688 KKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKC---LNDAYEVE-PGNGGCRDNHLKMLNVK 748
            ....:.::.:.|..|:.|||.|:|.|:|:|..|::.   |::.|::: .|....:...|:    :
  Rat  1005 TMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLE----E 1065

  Fly   749 TYLIK------RTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSG 799
            ||.:.      |:.|.....:.|.....|:...:.|.........|.|:|...:|.|
  Rat  1066 TYWLTGKTGFCRSLPTPLSIQPGDPWQDHINQEIRTGFAKARQSLAEPRSSGDTGPG 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	69/323 (21%)
		CYCc	526..729	CDD:214485	59/207 (29%)
		Guanylate_cyc	566..753	CDD:278633	52/192 (27%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	38/197 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556		6/26 (23%)
		PK_GC-2D	554..824	CDD:270945	62/323 (19%)
		CYCc	861..1050	CDD:214485	59/204 (29%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		17/49 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900