Protein Alignment Ac78C and ADCY5

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 1624
• Identity: 458/1624 - (28%)
• Similarity: 702/1624 - (43%)
• Gaps: 449/1624 - (27%)

  Fly    56 SDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDK--------------------GAIALA 100
            |.:|..:||  |....|:|||...|.|:.|.....|..:                    ||:...
Human     2 SGSKSVSPP--GYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQ 64

  Fly   101 QIDDL--KLEGDDDDEAVVNGEE--VDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSE 161
            |...|  :...||||:..::|::  ..|.|.|..:.....:......|.|:......||...|:
Human    65 QQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGST- 128

  Fly   162 QDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQ 226
                             |.|..|     .|.|....:..|                   ||
Human   129 -----------------RAPPAG-----GGGGSAAAAASA-------------------GG---- 148

  Fly   227 TPLRVQSVRI-VEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFK 290
            |.:|.:||.: :|.:|..|  |..:..........|...:.|:|..|  |....|
Human   149 TEVRPRSVEVGLEERRGKG--RAADELEAGAVEGGEGSGDGGSSADS--GSGAGP---------- 199

  Fly   291 SGNVVK-GILCPSL-----TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWIM 348
             |.|:. |..|.:|     :..|....|||.|..|..|..|.|| :::.|:..|..::|||
Human   200 -GAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAF---- 259

  Fly   349 RRSELGPIESDDGTSMATAI----TWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQ 409
             .:...|::......:|.|:    ..:|.|..|......:|. .|:|...:..|.....:|....
Human   260 -HAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL-ACYALIAVVLAVQVVGLLLPQP 322

  Fly   410 GFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATIN 474
            ....:|         :|:.:|.|:..|.:||:.::..|:.|.:.::.|||:......|
Human   323 RSASEG---------IWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQ------- 371

  Fly   475 PECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSIL 539
            .:.:|.|:.:|.::::..|:.|:.|.|..:..||.||.||.:.::.:..|::|.|:.::||.|:|
Human   372 DQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVL 436

  Fly   540 PNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLF 604
            |..|..::::::....:   :..|:|:|:...||||||||||:|||.|||:.:||:||..||:||
Human   437 PRHVAMEMKADINAKQE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELF 498

  Fly   605 ARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDL 669
            ||||::|.:|||||:|:|||||||||...    :.|.|||.|.||.|:.||:||..||..|.|::
Human   499 ARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVEMGMDMIEAISLVREVTGVNV 559

  Fly   670 NMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGN 734
            |||:|||||.|.|||||.:||.||||||||.:|||||:||..||:||::|||..||..||||||.
Human   560 NMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGC 624

  Fly   735 GGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSG 799
            ||.|:.:||..:::|:||.|                            |.
Human   625 GGERNAYLKEHSIETFLILR----------------------------CT--------------- 646

  Fly   800 SIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIR 864
                                                  |::|:..::         :|..:|:..
Human   647 --------------------------------------QKRKEEKAM---------IAKMNRQRT 664

  Fly   865 NGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIED 929
            |..|
Human   665 NSIG------------------------------------------------------------- 668

  Fly   930 ESTTDWIPEIPFKNL---NSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKE 991
            .:...|..|.||.|.   |.....:.|..  ..|.|:.:....|..::|:|||:.:.|...|...
Human   669 HNPPHWGAERPFYNHLGGNQVSKEMKRMG--FEDPKDKNAQESANPEDEVDEFLGRAIDARSIDR 731

  Fly   992 IRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPR----------C 1046
            :|.|::..:.|.|::...|:|:.:..:|.|.:.:.|..::::|:...|:.|:|.          |
Human   732 LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTC 796

  Fly  1047 TRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVI-VSMCMLSA- 1109
            :.|:..:...:||  :.||.:       .|..|:|.|.|:|..:...||  .||. :::..|:|
Human   797 SLLLTLVVFVSVI--YSCVKL-------FPSPLQTLSRKIVRSKMNSTL--VGVFTITLVFLAAF 850

  Fly  1110 IGLVLCPSSTYIG-TADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTP 1173
            :.:..|.|...:| .|.||           |||
Human   851 VNMFTCNSRDLLGCLAQEH-----------NIS-------------------------------- 872

  Fly  1174 LVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVE 1238
                          .|.:||..:                             ::::|..|..|.:
Human   873 --------------ASQVNACHV-----------------------------AESAVNYSLGDEQ 894

  Fly  1239 G-------QCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMK--------- 1287
            |       .|..|||..::.:|.|::.:..|::..:.|.::.||:...|..::.:.
Human   895 GFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD 959

  Fly  1288 ----------FGSGDS-FSLVELSR-------LGMPLGVQ--------------MLILLISFLVM 1320
                      |.:|.| :||.|..|       ...|.||:              :..::||..|:
Human   960 LLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVL 1024

  Fly  1321 VCY-HARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-HTDELYS 1383
            ..| ||:.||.|:||||:||.||..|...|:..:|.|..|:.||||..||.::|:.| ..||||.
Human  1025 ALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 1089

  Fly  1384 KMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATY 1446
            :......||||||.||.:||.| :.:| |..|:|:|||||.||||::.|.||..:|||||:|:||
Human  1090 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTY 1154

  Fly  1447 MAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGA 1511
            |||:|||.......|:|   .:..|.:||..:..:::.||..:|||||:::|:..||:|:|||||
Human  1155 MAASGLNDSTYDKVGKT---HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGA 1216

  Fly  1512 RKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575
            |||.||||||||||||||||||...|:||..:..::|.:..|....||.:.|||||.|.|::::
Human  1217 RKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	82/346 (24%)
		Guanylate_cyc	566..753	CDD:425528	114/186 (61%)
		Adcy_cons_dom	929..1021	CDD:461877	23/94 (24%)
		Guanylate_cyc	1381..1576	CDD:425528	99/197 (50%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	118/543 (22%)
		Guanylate_cyc	460..643	CDD:425528	114/186 (61%)
		Adcy_cons_dom	668..761	CDD:461877	24/155 (15%)
		Guanylate_cyc	1087..1281	CDD:425528	99/197 (50%)