DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac78C and ADCY2

DIOPT Version :9

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:1323 Identity:405/1323 - (30%)
Similarity:638/1323 - (48%) Gaps:305/1323 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 LERS----YLTYTHRQRQKSLIIVNVVDFVLKIV----LAFVWIMRRSELGPIESDDGTSM---- 364
            |.||    |.:|....:|..||:     |:|.||    ||.:.:.  ..|| :|.:|..:.    
Human    26 LPRSRDWLYESYYCMSQQHPLIV-----FLLLIVMGSCLALLAVF--FALG-LEVEDHVAFLITV 82

  Fly   365 --ATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFV----GQGVGFADREY 423
              |.||.:::.     :.:|....::    ..|...::..|:.....|::    |..|...|:  
Human    83 PTALAIFFAIF-----ILVCIESVFK----KLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQ-- 136

  Fly   424 LVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITI-IKLQHGEATINPECVLFQIFANFI 487
             |.:.||:|||.|.|||..::..::...:|:|.|..|::: :....|    ..|.:::||.||.|
Human   137 -VSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPG----GKEHLVWQILANVI 196

  Fly   488 LYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY 552
            ::...|:||.|.|:|.:...:..:.:|...::.:.:.|.|.::.::||.|:||..:..::::|:.
Human   197 IFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEII 261

  Fly   553 ------KGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIA 611
                  |.........|:.|||....|||||:|||.|||.|||..|..:||.:||:||.:||:||
Human   262 QRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIA 326

  Fly   612 EDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIH 676
            ::|.|:|:|:|||||||||....    :.|:||...|:.||.|.:|||.||..|.||:|||:|:|
Human   327 KENECMRIKILGDCYYCVSGLPI----SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVH 387

  Fly   677 SGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNH 741
            ||:|:|||:|.:||.:||||:||.:|||||:||:|||||||..||:.||.||:||.|:|..||.:
Human   388 SGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452

  Fly   742 LKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTA 806
            ||...||||.:     :.||..  .||..||.....|.                           
Human   453 LKQHLVKTYFV-----INPKGE--RRSPQHLFRPRHTL--------------------------- 483

  Fly   807 TGNDGASIDG--RSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGV 869
               |||.:..  |...|..:..  |.:|...|..:                   ||....||   
Human   484 ---DGAKMRASVRMTRYLESWG--AAKPFAHLHHR-------------------DSMTTENG--- 521

  Fly   870 MGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTD 934
                                                                       ..||||
Human   522 -----------------------------------------------------------KISTTD 527

  Fly   935 WIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQ-INSNKE-IRREYL 997
                :|.        |.:...:..:.||...:    ..:||::|.:.|.|. ||:.|: ::.|.:
Human   528 ----VPM--------GQHNFQNRTLRTKSQKK----RFEEELNERMIQAIDGINAQKQWLKSEDI 576

  Fly   998 NPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTF 1062
            ...:|.|.:|..|:::.......|:..:.|..:|:..:.:.|::::|:.:  ::.:|.|...|..
Human   577 QRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTS--VLGISFGAAFLLL 639

  Fly  1063 CCVLVMAEEFPG-LPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADE 1126
            ..:|.:.  |.| |.:|.|..|..|                 |.:|.:.|::.            
Human   640 AFILFVC--FAGQLLQCSKKASPLL-----------------MWLLKSSGIIA------------ 673

  Fly  1127 HSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTL 1191
             :|      |:..||:|  .....:.|...:.:...:|                 .|:|.:    
Human   674 -NR------PWPRISLT--IITTAIILMMAVFNMFFLS-----------------DSEETI---- 708

  Fly  1192 NALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLV 1256
                    ||        |..|...|.|.||   :..:::::.:     .....|.:::.:|.|:
Human   709 --------PP--------TANTTNTSFSASN---NQVAILRAQN-----LFFLPYFIYSCILGLI 749

  Fly  1257 SLATALKLYYLVKALMALAMVAFYTTLIMMKFGS--GDSFSLVELSRLGM-----PLG-VQMLIL 1313
            |.:..|::.|.:|.|:.:..:..|.|:::.....  || :|.|...|.|:     .:| |.:.|.
Human   750 SCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGD-YSQVLFERPGIWKDLKTMGSVSLSIF 813

  Fly  1314 LISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-H 1377
            .|:.||:    .|..|...||||:||.:.::|...:::...||..|::|:||.|||.::|:.. .
Human   814 FITLLVL----GRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLK 874

  Fly  1378 TDELYSKMHNLCGVMFASIPNFQDFYSE-DID-NGKACIRILNEIICDFDELLEEPRFASVEKIK 1440
            .:|||.:.::...|||||||:|::||:| |:: .|..|:|:|||||.|||:||.:|:|:.|||||
Human   875 NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIK 939

  Fly  1441 TVGATYMAAAGL----NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICS 1501
            |:|:|||||.||    :.||.: ..|.....:..:||||||:..||:.||..:||:|:|||||..
Human   940 TIGSTYMAATGLSAVPSQEHSQ-EPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINH 1003

  Fly  1502 GPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGK 1566
            ||:::|||||:||.||||||||||||||||||...::||.|.|:.:|.:.||||..||.|.||||
Human  1004 GPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGK 1068

  Fly  1567 GMMTTFYVH---PKGISESQLIS 1586
            |.:.|::|:   .:.:|:|.:.|
Human  1069 GDLKTYFVNTEMSRSLSQSNVAS 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831 63/257 (25%)
CYCc 526..729 CDD:214485 104/208 (50%)
Guanylate_cyc 566..753 CDD:278633 108/186 (58%)
DUF1053 929..1020 CDD:283888 21/92 (23%)
CYCc 1353..1554 CDD:214485 108/207 (52%)
Guanylate_cyc 1381..1576 CDD:278633 110/203 (54%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 60/250 (24%)
CYCc 236..439 CDD:214485 103/206 (50%)
Guanylate_cyc 281..465 CDD:278633 108/192 (56%)
DUF1053 495..599 CDD:283888 29/202 (14%)
CYCc 848..1056 CDD:214485 108/208 (52%)
Guanylate_cyc 878..1077 CDD:278633 109/199 (55%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 8/16 (50%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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