DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac78C and ADCY1

DIOPT Version :9

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:NP_066939.1 Gene:ADCY1 / 107 HGNCID:232 Length:1119 Species:Homo sapiens


Alignment Length:1378 Identity:399/1378 - (28%)
Similarity:603/1378 - (43%) Gaps:404/1378 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 GNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQ----KS 327
            |...|..||.::|..........::.:  :...||         .||..:..||.|..|    |:
Human    11 GGGGAGEPGGAERAAGTSRRRGLRACD--EEFACP---------ELEALFRGYTLRLEQAATLKA 64

  Fly   328 LIIVNV--------------------------VDFVLKIVLAFVWIMRRSELGPIESDDGTSMAT 366
            |.::::                          |..||.:.|..|..:|..::..::.....::..
Human    65 LAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLF 129

  Fly   367 AITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFN-IQGFVGQGVGFADREYLVWYILF 430
            ::|:::.|                          |.:.|.. .:|..|...|.|..|..||.:|.
Human   130 SLTFALLC--------------------------CPFALGGPARGSAGAAGGPATAEQGVWQLLL 168

  Fly   431 VIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINP---ECVLFQIFANFILYTAI 492
            |.||.||:||:.....:..|.:.|:.||.|         .||:.|   ..:...:.||.:|:..:
Human   169 VTFVSYALLPVRSLLAIGFGLVVAASHLLV---------TATLVPAKRPRLWRTLGANALLFVGV 224

  Fly   493 NVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDP 557
            |:.|::.:.||:|.||.||::....:|.:...|.|.::.::||.|:||..|..:::.:..|    
Human   225 NMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLK---- 285

  Fly   558 TVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLL 622
            ..|..|:|:|:...||||||||||.|||.|||:.:||:|||:||:||.:||.:|.:|||.|:|:|
Human   286 PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKIL 350

  Fly   623 GDCYYCVSQFESDNWKTRP--DHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVL 685
            ||||||||..      |:|  |||.|.||.||.||..|..|...|.||||||:|:|:|.|:||||
Human   351 GDCYYCVSGL------TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVL 409

  Fly   686 GNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTY 750
            |.:||.:|||||||.:||.||:.|:||:|||::.||.|||..||||||.|..|::.||..|::|:
Human   410 GLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETF 474

  Fly   751 LIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASID 815
            .|                                                               
Human   475 FI--------------------------------------------------------------- 476

  Fly   816 GRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGG 880
                       ||:          .::.|    .|.::......::|::                
Human   477 -----------VPS----------HRRKI----FPGLILSDIKPAKRMK---------------- 500

  Fly   881 TGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLN 945
                 ..||        ..|.|||      ...:.:.:|                  ||||.|:.
Human   501 -----FKTV--------CYLLVQL------MHCRKMFKA------------------EIPFSNVM 528

  Fly   946 SPEDGLNRADSILVDTKEDHRVSVA------VLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKF 1004
            :.||...|........|..:|.|.:      .....::.:|.:.::.... |:....||.:|||:
Human   529 TCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQT-ELEMADLNFFTLKY 592

  Fly  1005 KDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFC------ 1063
            |...:|||:.||:::.|.|.::...::.....|..::|.|:...:::       :|.||      
Human   593 KHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLL-------LLVFCICFLVA 650

  Fly  1064 CVLVM----AEEFPGLPRCLKTNSAKLVHQRQRRT---LFICGVIVSMCMLSAIGLVLCPSSTYI 1121
            |||.:    .:.|||   ||..         |.||   :||..:|.|:.....:|.:        
Human   651 CVLYLHITRVQCFPG---CLTI---------QIRTVLCIFIVVLIYSVAQGCVVGCL-------- 695

  Fly  1122 GTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEF 1186
                          |::                                       .||.|:...
Human   696 --------------PWA---------------------------------------WSSKPNSSL 707

  Fly  1187 VRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTW 1251
            |                      .|::.|...:|..|                .|....:.:   
Human   708 V----------------------VLSSGGQRTALPTL----------------PCESTHHAL--- 731

  Fly  1252 VLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLV-ELS---RLG----MPLGV 1308
            :.|||. ...|.:::.|.:|..:.:::..||          |:.|| |||   |.|    .....
Human   732 LCCLVG-TLPLAIFFRVSSLPKMILLSGLTT----------SYILVLELSGYTRTGGGAVSGRSY 785

  Fly  1309 QMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL 1373
            :.::.::.|...:..|||.|::..|||::|..|||.|..:|:..:..|..::.|:||.|||.::|
Human   786 EPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFL 850

  Fly  1374 -SDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFAS 1435
             |:....:||.:.::..||||||||||.|||.| |.:| |..|:|:|||||.|||||:|:..:..
Human   851 MSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKD 915

  Fly  1436 VEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCD----LVEFAFAMKQKLEEINGDAFNNFQLR 1496
            :|||||:|:|||||.||    ....|..::.|:..    |.:||..|...|:|||..::|:|.||
Human   916 IEKIKTIGSTYMAAVGL----APTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLR 976

  Fly  1497 VGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEI 1561
            |||..||:|:||||||:|.||||||||||||||||||...|:||.|....||....|..|.||::
Human   977 VGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKV 1041

  Fly  1562 AVKGKGMMTTFYV 1574
            :|||||.|.|:::
Human  1042 SVKGKGEMLTYFL 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831 64/296 (22%)
CYCc 526..729 CDD:214485 108/204 (53%)
Guanylate_cyc 566..753 CDD:278633 109/188 (58%)
DUF1053 929..1020 CDD:283888 24/96 (25%)
CYCc 1353..1554 CDD:214485 105/207 (51%)
Guanylate_cyc 1381..1576 CDD:278633 107/200 (54%)
ADCY1NP_066939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 5/16 (31%)
AC_N <161..292 CDD:292831 41/143 (29%)
CYCc 258..453 CDD:214485 108/204 (53%)
Guanylate_cyc 294..476 CDD:278633 109/187 (58%)
Interaction with calmodulin. /evidence=ECO:0000250 493..520 7/61 (11%)
CYCc 826..1037 CDD:214485 107/214 (50%)
Guanylate_cyc 859..1056 CDD:278633 107/200 (54%)
Interaction with calmodulin. /evidence=ECO:0000250 1024..1047 9/22 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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