DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy3

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1420	Identity:	409/1420 - (28%)
Similarity:	622/1420 - (43%)	Gaps:	355/1420 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 GNSNFEHDLE-SGNSLASIPGQSQRPL-NNEMYSAFKSGNVVKGILC-PSLTN-SFKQSSLERSY 316
            |.|:.|:..| |.....|:|....|.: .....|...||:    .|| |.... :|...|||..|
Mouse     6 GFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGS----CLCLPRFMRLTFVPESLENLY 66

  Fly   317 LTYTHRQRQKSLIIVNVVD--FVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCC----- 374
            .||..|||.::|:::.|..  |...:|:....:....:|.|: ...|..:...|...|.|
Mouse    67 QTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPL-MVAGFGLVLDIILFVLCKKGLL 130

  Fly   375 --GIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGF----ADREYLVWYILFVIF 433
              .::...:.:|                 .|:|.:.|.|...|:.|    |..:.:.|...|| |
Mouse   131 PDRVSRKVVPYL-----------------LWLLISAQIFSYLGLNFSRAHAASDTVGWQAFFV-F 177

  Fly   434 VPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMY 498
            ..:..|||.|...|:...::...|..|:.:...|..:..:....:|.:|.||..||....:.|:.
Mouse   178 SFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIM 242

  Fly   499 TKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQF 563
            :.|:.||..|.||:|..:::|.|...|::.|:.:.|:.||||..|.:::..:|.|......:.||
Mouse   243 SYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQF 307

  Fly   564 NKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYC 628
            |.:|:|..:|||||||||.|||:|:|..|||:|||:||:||||||::|...|.||:|:|||||||
Mouse   308 NTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYC 372

  Fly   629 VSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFD 693
            :.....    .|.||||||:..||.|::||..||..|...::||:|:|:|:|:.||||.|:|.:|
Mouse   373 ICGLPD----YREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   694 VWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEP- 757
            |||.||.:||.||:||||||||||::|:.||...::||||:||.|.::|....::||||..::|
Mouse   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPE 498

  Fly   758 LRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYA 822
            ::...:.|...||     |...||..:.|:: |..|.          |...|..|...|.:.|.|
Mouse   499 VKKTAQNGLNGSA-----VPNGAPASSKPSS-PALIE----------TKEPNGSAHASGSTSEEA 547

  Fly   823 ATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMS 887
            ......|..|               |.||       ..||:|
Mouse   548 EEQEAQADNP---------------SFPN-------PRRRLR----------------------- 567

  Fly   888 TVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLN 952
                                     :|:||:.:
Mouse   568 -------------------------LQDLADRV-------------------------------- 575

  Fly   953 RADSILVDTKEDHR-----VSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQK 1012
                  ||..||..     ::.|:|:.|..:.:::          |..:|  .|::|.|...|.:
Mouse   576 ------VDASEDEHELNQLLNEALLERESAQVVKK----------RNTFL--LTMRFMDPEMETR 622

  Fly  1013 FCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFP-GLP 1076
            :...:|....:...|..|:.....:.:::|.|......:...||.|:|....:..||..|| ..|
Mouse   623 YSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRSFP 687

  Fly  1077 RCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNIS 1141
            :.|...|:.:...|..|..:....|..:.|.:.:.::.|
Mouse   688 KKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSC-------------------------- 726

  Fly  1142 MTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSH 1206
                   |..|:.
Mouse   727 -------LQYYMG---------------------------------------------------- 732

  Fly  1207 RPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQC-AHPEYLVFTWVLCLVSLATALKLYYLVKA 1270
             ||.:|                    :..:::|.| .:|:|..:..||.|::....:::.::||.
Mouse   733 -PYNMT--------------------AGMELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKL 776

  Fly  1271 LMALAMVAFYTTLIM------------MKFGSGDS--FSLVELSRLGMP---------------- 1305
            .:.|.:....|.|.:            .:|...||  .:|.::..|..|
Mouse   777 TLMLLVTGAVTALNLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKY 841

  Fly  1306 -LGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVA 1369
             :.|.|.::::||.    |.:|.||..:|..|:||.:...:...:...|..|:.|:.|:||:|||
Mouse   842 SMTVMMFVMMLSFY----YFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVA 902

  Fly  1370 TYYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSED-IDNGK-ACIRILNEIICDFDELLEEP 1431
            .::| |.:..:||||:.::..||||||:|||.|||:|: |:||. .|:|.|||||.|||.||:.|
Mouse   903 RHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNP 967

  Fly  1432 RFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDS-----------VCDLVEFAFAMKQKLEEI 1485
            :|..:.||||:|:|||||:|:..: :...|.||...           :.||.:||.|||..|..|
Mouse   968 KFRVITKIKTIGSTYMAASGVTPD-VNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNI 1031

  Fly  1486 NGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCS 1550
            |..:||||.||:|:..|.:::||||||||.||||||||||||||:|||....:||.|.|..:|..
Mouse  1032 NNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 1096

  Fly  1551 RGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQ 1605
            .|:..|:||.|.|||||.:.||::  ||...         ||..|...:..|..|
Mouse  1097 YGFRFVRRGPIFVKGKGELLTFFL--KGRDR---------PAAFPNGSSVTLPHQ 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	69/277 (25%)
		CYCc	526..729	CDD:214485	104/202 (51%)
		Guanylate_cyc	566..753	CDD:278633	103/186 (55%)
		DUF1053	929..1020	CDD:283888	14/95 (15%)
		CYCc	1353..1554	CDD:214485	108/214 (50%)
		Guanylate_cyc	1381..1576	CDD:278633	107/207 (52%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	70/281 (25%)
		Guanylate_cyc	310..494	CDD:306677	104/187 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		20/97 (21%)
		Guanylate_cyc	915..1122	CDD:306677	107/209 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710