Protein Alignment Ac78C and Adcy4

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_536683.1
• Gene: Adcy4 / 104110
• MGIID: 99674
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1304
• Identity: 395/1304 - (30%)
• Similarity: 609/1304 - (46%)
• Gaps: 299/1304 - (22%)

  Fly   316 YLTYTHRQRQKSLIIVNVVDFVLKIVL--AFVWIMRRSELGPIESDDGTSMATAIT----WSVCC 374
            |.||....:|..|:|:.:|..:..:|.  |..|...| ||    :.|.:.:.|.:.    :|:..
Mouse    17 YETYYSLSQQYPLLILLLVIVLCALVALPAVAWASGR-EL----TSDPSFLTTVLCALGGFSLLL 76

  Fly   375 GIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVW----YILFVIFVP 435
            |:|:.......:.|..:.  |.|.|:..         :|.|..|.......|    :.||:||..
Mouse    77 GLASREQQLQRWTRPLSG--LIWVALLA---------LGYGFLFTGGVVSAWDQVSFFLFIIFTV 130

  Fly   436 YAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTK 500
            ||||||.::.....|.|::..||.|   :.|..|....:...:|.|:.||.:|:...||.|.|.|
Mouse   131 YAMLPLGMRDAAAAGVISSLSHLLV---LGLYLGWQPESQRALLPQLAANAVLFLCGNVVGAYHK 192

  Fly   501 YLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY------KGTDPTV 559
            .|.:|..|..|.|...::..::..:.|.:..:.||.||||..:..::::|:.      :.:.|..
Mouse   193 ALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQRSRPEN 257

  Fly   560 ETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGD 624
            ...|:.|||.....||:|:|||.|||.|||:.|.::||.:||:||.:||:||:::.|:|:|:|||
Mouse   258 TNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGD 322

  Fly   625 CYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKK 689
            ||||||...    .:.||||:..|..||.|.:||:.:|:.|.||:|||:|:|||||:|||:|.:|
Mouse   323 CYYCVSGLP----LSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQK 383

  Fly   690 WHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKR 754
            |.:||||:||.:|||||:||:||||||:.|||..|..||.||..:...||.:|:.|...|||:
Mouse   384 WQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADTEHRDPYLRELGEPTYLV-- 446

  Fly   755 TEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSL 819
                                             ..|::......|:..|:.      :|::|.::
Mouse   447 ---------------------------------IDPRAEEEDEKGTAKGLL------SSLEGHTM 472

  Fly   820 EYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGP- 883
            .       |:...|:.|:                                       ..|...|
Mouse   473 R-------PSLLMTRYLE---------------------------------------SWGAAKPF 491

  Fly   884 CGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPE 948
            ..:|.:.||.                                     ||:..:||..|    ||:
Mouse   492 AHLSHLDSPV-------------------------------------STSTPLPEKAF----SPQ 515

  Fly   949 DGLNRADSILVDTKEDHRVSVAVLDEEID----EFIEQNIQINSNKEIRR-EYLNPWTLKFKDKS 1008
            ..|:|:.            :...||:|:|    :|.:...|:||.|:.:: :..|..||.|::|.
Mouse   516 WSLDRSR------------TPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYFREKE 568

  Fly  1009 QEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFP 1073
            .|:::.......|:....|.|::::.....|:::..|...|||..|: |.:|.|..:.|...|.
Mouse   569 MEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRPPALIITYSI-TFLLFFLLLFVCFSEH- 631

  Fly  1074 GLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTY---IGTADEHSRFLRMVS 1135
             |.:|:: ...|::|                 .|.|:.:::.....:   :|||
Mouse   632 -LTKCVQ-KGPKMLH-----------------WLPALSVLVATRPGFRVALGTA----------- 666

  Fly  1136 PYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSD-EFVRSTLNALTLNLT 1199
                          .:.|..|:.....:..|.|              || .|:.|.::::|.|.:
Mouse   667 --------------TILLVFTMAIASLLFLPVS--------------SDCLFLASNVSSVTFNAS 703

  Fly  1200 PPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKL 1264
            ..:|.| .|..      |:.|.::.||               .|...|.|......:.::..|||
Mouse   704 WEMPGS-LPLI------SIPLISIPYS---------------MHCCVLGFLSCSLFLHMSFELKL 746

  Fly  1265 YYLVKALMA-----LAMVAFYTTLIMMKFGSGDSFS----LVELSRLGMPLGVQMLILLISFLVM 1320
            ..|:..|:|     |...|:.:..::.:.....|.|    |.|...:|   .:...|...:.||:
Mouse   747 LLLLLWLVASCSLFLHSHAWLSDCLIARLYQSPSDSRPGVLKEPKLMG---AIYFFIFFFTLLVL 808

  Fly  1321 VCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL-SDEHTDELYSK 1384
                ||..|...||||:||::..:|....::...|...|::|:||.|||..:: .:...::||.:
Mouse   809 ----ARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 869

  Fly  1385 MHNLCGVMFASIPNFQDFYSEDIDN--GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYM 1447
            .:....|:|||:|:|::||||...|  |..|:|:|||||.||||||.:|:|:.||||||:|:|||
Mouse   870 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYM 934

  Fly  1448 AAAGLNHEHLRLRGETSEDS--VCD----LVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVS 1506
            ||.|||....:   :|.:||  .|.    :||||.|:..||..||..:||||:||||:..||:|:
Mouse   935 AATGLNATSGQ---DTQQDSERSCSHLGTMVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVA 996

  Fly  1507 GVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTT 1571
            |||||:||.||||||||||||||:|||...::||.|.||..|.|.||||..||.|.|||||.:.|
Mouse   997 GVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELCT 1061

  Fly  1572 FYVH 1575
            ::::
Mouse  1062 YFLN 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	65/244 (27%)
		Guanylate_cyc	566..753	CDD:425528	101/186 (54%)
		Adcy_cons_dom	929..1021	CDD:461877	24/96 (25%)
		Guanylate_cyc	1381..1576	CDD:425528	112/203 (55%)
Adcy4	NP_536683.1	AcyC	40..453	CDD:441717	163/470 (35%)
		Guanylate_cyc	264..447	CDD:425528	101/221 (46%)
		Adcy_cons_dom	479..581	CDD:461877	31/193 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..524		8/36 (22%)
		Guanylate_cyc	866..1065	CDD:425528	112/201 (56%)