Protein Alignment Ac78C and gucy1b2

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_017949923.2
• Gene: gucy1b2 / 100496697
• XenbaseID: XB-GENE-989428
• Length: 781
• Species: Xenopus tropicalis
• Alignment Length: 641
• Identity: 127/641 - (19%)
• Similarity: 234/641 - (36%)
• Gaps: 203/641 - (31%)

  Fly   994 REYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTV 1058
            :.:.||:. |::|:..:...|.::::.           |..:            |.|:.|..|.:
 Frog   226 KSFENPYN-KYRDRKNQVSVCPVKKNH-----------WAMI------------RGIVQLGKGRM 266

  Fly  1059 ILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGT 1123
            :..|         .|..|:.|                  |..:.:.|......:|.
 Frog   267 LRGF---------RPVYPKDL------------------CVDVETFCKGLPFHIVF--------- 295

  Fly  1124 ADEHSRF------LRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGP 1182
             ||..|.      ::.:.|    .:.....:|:.|.| |:|..:|::          :.......
 Frog   296 -DEELRIKQAGVSIQKIVP----GLQTTGIRLDQYFS-TVHPEVTLT----------ISNVRKFI 344

  Fly  1183 SDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYL 1247
            :.:||..|...:       :|:|.|                   |..::    ::.||....|.|
 Frog   345 NSQFVFRTKREM-------MPESWR-------------------DRPML----ELRGQMIWMEKL 379

  Fly  1248 VFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLI 1312
            .....||...|.|   |:.|.:..|.::.:|                          |..|...:
 Frog   380 ECMLYLCSPLLRT---LHELEERQMHISDIA--------------------------PHDVTRDL 415

  Fly  1313 LLISFLVMVCYHARL--VEVTSRLDFIWKEQAEREL----TNMKSNRALNDTLIKNILPDHVATY 1371
            :|::       ..||  :|::::|     |:.:.||    .:::..:...:.|:..:||.|||..
 Frog   416 ILLN-------QQRLAEMELSNQL-----ERKKEELRILSKHLEEEKKKTELLLYAMLPKHVANQ 468

  Fly  1372 YLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKAC-----IRILNEIICDFDELLEEP 1431
            ....:..:....|.   |.::|:.:..|.:..::       |     :.:||.:...||.|   .
 Frog   469 LKEGKRVEAGEFKE---CTILFSDVVTFTNICAQ-------CEPIQIVFMLNSMYLRFDRL---T 520

  Fly  1432 RFASVEKIKTVGATYMAAAGL-----NHEHLRLRGETSEDSVCDLVEFAFAM----KQKLEEING 1487
            ....|.|::|:|..||...|:     :|..             .:..||..|    ||....:||
 Frog   521 TVHDVYKVETIGDAYMVVGGVPVPVSSHAE-------------RVANFALGMILMAKQVKNPVNG 572

  Fly  1488 DAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRG 1552
               |..|:|||:.|||:::||:|.:.|.|.::|:|||.||||:|.|...::.:.......|..:.
 Frog   573 ---NPIQIRVGLHSGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPNKIHISPTVYRYLKGKN 634

  Fly  1553 YTCVKRGEIAVKGKGMMTTFY-VHPKGISESQLISPVRMPAGIPLAQTPNLQRQTS 1607
            :...:||||.|||||.|.|:: :......|::::...........|.:.:|...||
 Frog   635 FEMTERGEIDVKGKGRMRTYFLIRNSSAKENEILGQAIKETDSGRASSQSLLDDTS 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454
		Guanylate_cyc	566..753	CDD:425528
		Adcy_cons_dom	929..1021	CDD:461877	5/26 (19%)
		Guanylate_cyc	1381..1576	CDD:425528	60/209 (29%)
gucy1b2	XP_017949923.2	HNOB	21..182	CDD:462233
		HNOBA	280..469	CDD:462234	47/284 (17%)
		CYCc	448..633	CDD:214485	55/213 (26%)