DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and adcy1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_002933461.1	Gene:	adcy1 / 100492373	XenbaseID:	XB-GENE-950909	Length:	1122	Species:	Xenopus tropicalis

Alignment Length:	1249	Identity:	373/1249 - (29%)
Similarity:	563/1249 - (45%)	Gaps:	361/1249 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 VWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINP--ECVLFQIFANFI 487
            :|.::.|.||.||:||:.....:|.|.:.:..|:.|..        .:|:|  :.:...:..|.|
Frog   153 LWQLMLVTFVAYALLPVRTLLAIVFGFMVSVSHIIVTA--------TSISPKKKRLWRTLVVNAI 209

  Fly   488 LYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY 552
            |:.::|::|::.:.||:|.||.||::....:|.:...|.|.::.::||.|:||..|..:::.:..
Frog   210 LFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFL 274

  Fly   553 KGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCL 617
            |    ..|..|:|:|:...||||||||||.|||.|||:.:||:|||:||:||.:||.:|.:|||.
Frog   275 K----PPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCR 335

  Fly   618 RVKLLGDCYYCVSQFESDNWKTRP--DHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSV 680
            |:|:|||||||||..      |:|  |||.|.||.||.||..|..|...|.||||||:|:|:|.|
Frog   336 RIKILGDCYYCVSGL------TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRV 394

  Fly   681 MCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKML 745
            :|||||.:||.:|||||||.:||.||:||:||:|||::.||:|||..||||||.|..|::.||..
Frog   395 LCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLKKH 459

  Fly   746 NVKTYLI-----KRTEP------LRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSG 799
            |::|:.|     ::..|      ::|.:|...::..:|
Frog   460 NIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYL--------------------------- 497

  Fly   800 SIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLP--NVVEGVAMDSRR 862
                                               |:|....:.:....:|  ||:.....|.||
Frog   498 -----------------------------------LVQLMHCRKMFKAEIPFSNVMTCEDDDKRR 527

  Fly   863 IRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLII 927
                                  .:.|.|.             :.||.:....|:..
Frog   528 ----------------------ALRTASE-------------KLRNRSSFSTNVIH--------- 548

  Fly   928 EDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEI 992
                             |:|...:||....|::.::        .|.|:.:
Frog   549 -----------------NTPGTRVNRYIGRLIEARQ--------TDSEMSD-------------- 574

  Fly   993 RREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGT 1057
                ||..|||:|...:|||:.||.::.|.|.::...::.....|..::|.|:.|.::|
Frog   575 ----LNFITLKYKHIEREQKYHQLHDEYFTSAVVLSLILAALFGLVYLLIFPQSTIVLI------ 629

  Fly  1058 VILTFC-CVLV---------MAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGL 1112
             :|.|| |.||         ..:.|||   ||..         |.||: :|..||.:....|.|.
Frog   630 -LLVFCLCFLVACIMYLHVTRVQCFPG---CLTI---------QIRTI-LCIFIVILIYSVAQGC 680

  Fly  1113 VL-CPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVD 1176
            |: |  ..:|..::..|                               :|.|.||.....|
Frog   681 VVGC--MPWIWRSNNSS-------------------------------SIVIITPKGENKT---- 708

  Fly  1177 ITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQC 1241
                                       .:.||                                |
Frog   709 ---------------------------MNERP--------------------------------C 714

  Fly  1242 AHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMM----KFGSGDSFSLVELSRL 1302
            ....|...:.|:..:|||..|::....|.::.|.:...|..::.:    |...||:..:
Frog   715 DTAHYTFLSCVVGTLSLAIFLRISSFPKMVLLLFVTILYIVILEISGYRKTLGGDTSYM------ 773

  Fly  1303 GMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDH 1367
               .|.:.::.::.|...:..|:|.|::..|||::|..|||.|..:|:..:..|..::.|:||.|
Frog   774 ---RGYEPILAILLFSCSLALHSRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAH 835

  Fly  1368 VATYYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLE 1429
            ||.::| |:....:||.:.::..||||||||||.|||.| |.:| |..|:|:|||||.|||||:|
Frog   836 VAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELME 900

  Fly  1430 EPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSV----CDLVEFAFAMKQKLEEINGDAF 1490
            :..:..:|||||:|:|||.|.||    :...|..::.|:    ..|.:|:..|...|:|||..::
Frog   901 KECYKDIEKIKTIGSTYMGAVGL----VPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSY 961

  Fly  1491 NNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTC 1555
            |.|.|||||..||:|:||||||:|.||||||||||||||||||...::||.|:...:|.|..|..
Frog   962 NEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEF 1026

  Fly  1556 VKRGEIAVKGKGMMTTFY--------------------VHPKGISESQLISPVRMPAGIPLAQTP 1600
            |.||:::|||||.|.|::                    ::|.|.:..|.......||...::..|
Frog  1027 VCRGKVSVKGKGEMLTYFLEGKIDGTNSQTRSLNLERKMYPYGRTNIQTKLGTSCPAVSSISNFP 1091

  Fly  1601 ------NLQRQTSH 1608
                  .||..|||
Frog  1092 VKAGQGALQPTTSH 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	35/127 (28%)
		CYCc	526..729	CDD:214485	109/204 (53%)
		Guanylate_cyc	566..753	CDD:278633	111/193 (58%)
		DUF1053	929..1020	CDD:283888	18/90 (20%)
		CYCc	1353..1554	CDD:214485	102/207 (49%)
		Guanylate_cyc	1381..1576	CDD:278633	104/220 (47%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	37/140 (26%)
		CYCc	248..443	CDD:214485	109/204 (53%)
		Guanylate_cyc	284..466	CDD:278633	110/187 (59%)
		CYCc	817..1028	CDD:214485	104/214 (49%)
		Guanylate_cyc	850..1047	CDD:278633	104/200 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910