DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	112/422 - (26%)
Similarity:	190/422 - (45%)	Gaps:	91/422 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1184 DEFVRSTLNALTLNLTPPLPQSH----------RPYTLTTNGHSVSLSNLSYSDASVMQSSS--- 1235
            |.||....||: ..:.|.|...:          ||: :..:.|.: ||::  :...|::|..
Frog   226 DLFVTQCGNAI-YRVLPQLQPGNCNLLSVFSLVRPH-IDISFHGI-LSHI--NTVFVLRSKEGLL 285

  Fly  1236 DVEGQCAHPEYLVFTWVLCLVSLATALK--LYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVE 1298
            |||...:..| |..|.:.||     .||  :.||.:|...|.:.            |....:|.:
Frog   286 DVEKSESEDE-LTGTEISCL-----RLKGQMIYLPEADNILFLC------------SPSVMNLDD 332

  Fly  1299 LSRLGMPLGVQMLILLISFLVMVCYHAR-LVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKN 1362
            |:|.|:.|....|......||::....| ..::|..|: |..::.:..|..::..:...|||:.:
Frog   333 LTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELE-ILTDRLQHTLRALEDEKKKTDTLLYS 396

  Fly  1363 ILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRI---LNEIICDF 1424
            :||..||...   .|...:.:|.::...::|:.|..|..|.|:.. :|:..::|   ||:|...|
Frog   397 VLPPSVANEL---RHKRPVPAKRYDNVTILFSGIVGFNTFCSKHA-SGEGAMKIVNLLNDIYTRF 457

  Fly  1425 DELLEEPRFASVEKIKTVGATYMAAAGLNH---EHLRLRGETSEDSVC----DLVEFAFAMKQKL 1482
            |.|.:......|.|::|||..||..:|:..   .|.|        |:|    |::|.|..:
Frog   458 DILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHAR--------SICHLALDMMEIAGQV---- 510

  Fly  1483 EEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAEL 1547
             :::|:   :.|:.:||.:|.:|:||||.|.|.|.::|||||:.||.::|||..::.|.|.|
Frog   511 -QVDGE---SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYT--- 568

  Fly  1548 LCSRGYTCVK-------------RGEIAVKGK 1566
                 |.|:.             ||.:::|||
Frog   569 -----YRCLMSPENSDPQFHLQYRGPVSMKGK 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	63/210 (30%)
		Guanylate_cyc	1381..1576	CDD:278633	62/209 (30%)
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902
		HNOBA	207..406	CDD:369471	49/203 (24%)
		Guanylate_cyc	412..605	CDD:306677	62/209 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910