DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10565 and ZUO1

DIOPT Version :9

Sequence 1:	NP_001246856.1	Gene:	CG10565 / 40332	FlyBaseID:	FBgn0037051	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_011801.1	Gene:	ZUO1 / 853202	SGDID:	S000003517	Length:	433	Species:	Saccharomyces cerevisiae

Alignment Length:	445	Identity:	144/445 - (32%)
Similarity:	222/445 - (49%)	Gaps:	78/445 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VRRKIERVG--FAYFAQR-------RQFLAPGGVERSESDEKLEGVGE------------EVDIS 62
            |||.:|.||  |...|||       .:|      ||.|:::.::.|.|            |:...
Yeast    25 VRRPVEPVGKFFLQHAQRTLRNHTWSEF------ERIEAEKNVKTVDESNVDPDELLFDTELADE 83

  Fly    63 YLKSLDPKEWKDQDHYAVLGLGKLRYEASEDDVRRAYRRMVLLHHPDKRKAKGEEVIQDDDYFTC 127
            .|.:.|.::||..|.||.:||.|||:.|:|..:.:|:|:.|:.:||||:.|.|..:.| |.:|..
Yeast    84 DLLTHDARDWKTADLYAAMGLSKLRFRATESQIIKAHRKQVVKYHPDKQSAAGGSLDQ-DGFFKI 147

  Fly   128 ITKAYEILGTSKPRRSFDSVDPEFDDSLPSQNDIDNDYFGVFNKFFTLNGRWSEKPHVPSFGQVD 192
            |.||:|.|..|..|..:||.| ...|..|.:...|.|::..:...|....|:|:|..:||.|..|
Yeast   148 IQKAFETLTDSNKRAQYDSCD-FVADVPPPKKGTDYDFYEAWGPVFEAEARFSKKTPIPSLGNKD 211

  Fly   193 AKREEVERFYNFWYDFKSWREFSYLDEEDKEKGQDRDERRWIEKENRAARIKRKKEEMSRIRSLV 257
            :.::|||:||.||:.|.|||.|.:|||:..:...:||.:|:||::|:|||.|:|..:.:|:..||
Yeast   212 SSKKEVEQFYAFWHRFDSWRTFEFLDEDVPDDSSNRDHKRYIERKNKAARDKKKTADNARLVKLV 276

  Fly   258 DLAYNNDKRIQRFKQEEKDRKAAAKRAKMDAAQAQKAEADRAIREAALAKEKAE---------KA 313
            :.|.:.|.||:.||:|||..|   :|.|.:.....:|||:...:..|.||.|||         ||
Yeast   277 ERAVSEDPRIKMFKEEEKKEK---ERRKWEREAGARAEAEAKAKAEAEAKAKAESEAKANASAKA 338

  Fly   314 EQKRIEQIRIEREQQKKLLKKERKTLRDKVKDCKYYAKNDK----DQLKHMEGTEKICETFNLAE 374
            ::|:      .:|..|...||.::.:|:..|:..|:...||    |     |....|.::.|..|
Yeast   339 DKKK------AKEAAKAAKKKNKRAIRNSAKEADYFGDADKATTID-----EQVGLIVDSLNDEE 392

  Fly   375 LQALNKAMESKGRESFVAALQTAEQKI---AAELEEINQTQAKKLASSAATPKGV 426
            |                  :.||: ||   ||..:|:.:..||.:..|...|..:
Yeast   393 L------------------VSTAD-KIKANAAGAKEVLKESAKTIVDSGKLPSSL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10565	NP_001246856.1	CbpA	76..282	CDD:225124	83/205 (40%)
		DnaJ	76..145	CDD:278647	29/68 (43%)
		RILP-like	268..>344	CDD:304877	25/84 (30%)
		RAC_head	332..401	CDD:293322	15/72 (21%)
		SANT	584..633	CDD:197842
		SANT	585..632	CDD:238096
ZUO1	NP_011801.1	ZUO1	50..433	CDD:227594	134/420 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345508
Domainoid	1	1.000	123	1.000	Domainoid score	I1230
eggNOG	1	0.900	-	-		E1_KOG0724
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31656
Inparanoid	1	1.050	201	1.000	Inparanoid score	I852
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004281
OrthoInspector	1	1.000	-	-		oto99945
orthoMCL	1	0.900	-	-		OOG6_102149
Panther	1	1.100	-	-	LDO	PTHR43999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2016
SonicParanoid	1	1.000	-	-		X3017
TreeFam	1	0.960	-	-
	14	13.780