DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10565 and DNAJC18

DIOPT Version :9

Sequence 1:	NP_001246856.1	Gene:	CG10565 / 40332	FlyBaseID:	FBgn0037051	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_689899.1	Gene:	DNAJC18 / 202052	HGNCID:	28429	Length:	358	Species:	Homo sapiens

Alignment Length:	363	Identity:	75/363 - (20%)
Similarity:	138/363 - (38%)	Gaps:	108/363 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FAQRRQFLAPGGVERSESDEKLEGVGEEVDISYLKSLDPKEWKDQDHYAVLGLGKLRYEASEDDV 95
            :.|.||    |....:.|:|:|.||      ..:|       |.:::|.:||:.:   :||::::
Human    54 WTQTRQ----GEGNSTYSEEQLLGV------QRIK-------KCRNYYEILGVSR---DASDEEL 98

  Fly    96 RRAYRRMVLLHHPDKRKAKGEEVIQDDDYFTCITKAYEILGTSKPRRSFDSV-DPEFDDSLPS-- 157
            ::|||::.|..||||..|.|.     .|.|..|..|:.:|.....|..:|.. |.:...:.|.
Human    99 KKAYRKLALKFHPDKNCAPGA-----TDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRAR 158

  Fly   158 ----QNDIDNDYF--GVFNKFFTLNGRWSEKPHVPSFGQVDAKREEVERFYN-----FWYDFKSW 211
                ..|.:.|..  .:||.||  .|      |.|:        ..:..|.|     ::|..:..
Human   159 PYNYYRDFEADITPEELFNVFF--GG------HFPT--------GNIHMFSNVTDDTYYYRRRHR 207

  Fly   212 REFSYLDEEDKEKGQDRDERRWIE---------------------------KENRAARIKRKKEE 249
            .|.:...:|::|:........:|:                           |......|.|:.:.
Human   208 HERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQN 272

  Fly   250 MSRIRSLVDLAYNNDKRIQRFKQEEKDRKAAAKRAKMDAAQAQKAEADRAIREAALAKEKAEKAE 314
            : ::...||..::...|.......||    ..::..:|..|            .:..|||.:|:|
Human   273 L-QVPYFVDKNFDKAYRGASLHDLEK----TIEKDYIDYIQ------------TSCWKEKQQKSE 320

  Fly   315 QKRIEQI-RIEREQQKKLLKKERKTLRDKVKDCKYYAK 351
            ...:..: |.||      ||::.::|  |:::|:..:|
Human   321 LTNLAGLYRDER------LKQKAESL--KLENCEKLSK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10565	NP_001246856.1	CbpA	76..282	CDD:225124	48/246 (20%)
		DnaJ	76..145	CDD:278647	21/68 (31%)
		RILP-like	268..>344	CDD:304877	16/76 (21%)
		RAC_head	332..401	CDD:293322	6/20 (30%)
		SANT	584..633	CDD:197842
		SANT	585..632	CDD:238096
DNAJC18	NP_689899.1	DnaJ	82..143	CDD:278647	21/68 (31%)
DNAJC18	NP_689899.1	DUF1977	250..350	CDD:286411	23/124 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840