DRSC/TRiP Functional Genomics Resources

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Protein Alignment cacna1da and para

DIOPT Version :9

Sequence 1:XP_021335251.1 Gene:cacna1da / 403310 ZFINID:ZDB-GENE-030616-135 Length:2093 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2069 Identity:477/2069 - (23%)
Similarity:835/2069 - (40%) Gaps:653/2069 - (31%)


- Green bases have known domain annotations that are detailed below.


Zfish     6 PAPPAATPAAPP-AAAVPVPSVVPVGS------LAQKKR--AQYAKSKKQGSSANTRPQRALFCL 61
            |.|.....:.|| .|:.|:..:.|..|      :..|.:  .:::.||            |::.|
  Fly    84 PIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASK------------AMWML 136

Zfish    62 NLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTI 126
            :..|||||..|.::....|.:||:..|..||:.:.:          .|...:|:.|..|..|:|.
  Fly   137 DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTF 191

Zfish   127 ETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGK 191
            |:.:|::|.|.::....|:|:.||.||||::.:...::.:::            .||:       
  Fly   192 ESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDL------------GNLA------- 237

Zfish   192 PGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIG 256
                   |||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||::::|
  Fly   238 -------ALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 295

Zfish   257 KMHASCY----FQG-----TD-------------ILEDE----PAPCAVNGHGRTCPINGTLCKE 295
            .:...|.    ..|     ||             ..|||    |....::|.|: |. :..:|.:
  Fly   296 VLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CD-DDYVCLQ 358

Zfish   296 GW-QGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPW--VYFVSLVIFGSFFV 357
            |: ..||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||::
  Fly   359 GFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYL 420

Zfish   358 LNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLK---------------- 396
            :||:|.:::..:.:.::||:..  .:.:.:||.::        |||...                
  Fly   421 VNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAA 485

Zfish   397 --------------GYLDWITQAEDIDPENEEE--------EEES-----------------KRN 422
                          .|..::...:..|..|:|:        |.||                 |..
  Fly   486 LHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVR 550

Zfish   423 RVTLASL--------------MEKK---KKGFGWFS----------------------QSSDTHA 448
            :|:..||              ...|   :.|.|.|.                      .:.|::|
  Fly   551 KVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNA 615

Zfish   449 SMPASE--------------------------------------------------TESMNTENE 463
            ..|.||                                                  ...:...|.
  Fly   616 VTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNT 680

Zfish   464 KGEDEKATCCGPTCQKISKSKFSRRWRRWNRLCR------------------------------- 497
            :.:...||..|.||.. :..|...|.......|.                               
  Fly   681 RNQSVGATNGGTTCLD-TNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744

Zfish   498 ---------RNCRLAVKSVPFY-------------------------------------WL---- 512
                     |:.|.:.:.|..|                                     ||    
  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809

Zfish   513 -VIILVF-------------LNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGL 563
             |.::||             :||:.::.:|::....:.:|....|....|.|..|..:|:.::..
  Fly   810 WVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSP 874

Zfish   564 QAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLL 628
            :.||...:|.||..:|.     ..|:|..:....|:||.|..||||:||:.:.|.:|:.|::.:.
  Fly   875 KYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMG 934

Zfish   629 NSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFN-----FDETQTKRSTFDNFPQALLTVFQILTG 688
            .:|.::.:|..:|.:.|.||:::|||:||..::     |.:....|..|.:|..:.:.||::|.|
  Fly   935 RTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCG 999

Zfish   689 EDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNT----D 748
            | |...|:|.:..       |.:.|| :|:...:.||.::||:|||:.:.|.. :.||:.    :
  Fly  1000 E-WIESMWDCMYV-------GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSLSAPTADN 1055

Zfish   749 DTKKPDEI--------------------------------------------------------- 756
            ||.|..|.                                                         
  Fly  1056 DTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCIS 1120

Zfish   757 ------------DEI-------------------------------------------------- 759
                        |||                                                  
  Fly  1121 AEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDD 1185

Zfish   760 ---------------EDEAKAGE------EDEKDNAEED-------EEEPDVPAGPRPKISELV- 795
                           :||:..|.      |:::|.::||       :||.:...||..  .::: 
  Fly  1186 TASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD--GDIII 1248

Zfish   796 ---------------------KKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFI 839
                                 ||..|....:.|.|  :.....:|:...:||.:..|...::..|
  Fly  1249 HAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPF--WQGWGNLRLKTFQLIENKYFETAVITMI 1311

Zfish   840 MLSSASLAAEDPIRNFSARNI---ILGYFDYAFTAIFTVEIVLKMTTYGAFLH-KGAFCRNYFNL 900
            ::||.:||.||.  :...|.|   ||.|.|..||.||.:|:::|....|..:: ..|:|     .
  Fly  1312 LMSSLALALEDV--HLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC-----W 1369

Zfish   901 LDLLVVGVSLVSFG---IQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIM 962
            ||.::|.|||::|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::
  Fly  1370 LDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVL 1434

Zfish   963 IVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQPIIQKRH-------- 1019
            :|..:...:||.:|||||.||:::|        |:..||.:.::       ||..|:        
  Fly  1435 LVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHE-------IIPNRNACESENYT 1484

Zfish  1020 WHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAF 1084
            |.||..|||:|..|.:.||.|:||:||..::..||||...:..||....:.:.::|:.:||..:|
  Fly  1485 WVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSF 1549

Zfish  1085 FMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY----------ALKARPLRRYIPKNPYQY 1139
            |.:|:|:|.:|..|.||.:|...:.|:...:.|...|          .|||.|..|:.|    |.
  Fly  1550 FTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QA 1610

Zfish  1140 KFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKP 1204
            ..:.:|....|:.|:.:.|.||...:.:..|..|:.:|.|:|.||.:|..:|:.|.:||:.|.: 
  Fly  1611 IVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR- 1674

Zfish  1205 RHYFTDAWNTFDALIVVGSVVDIAITEVNPTEAPQVDESGNTEDSARISITFFRLFRVM---RLV 1266
            .|||.:.||.||.::|:.|::.:.::::              .:...:|.|..|:.||.   |::
  Fly  1675 YHYFIEPWNLFDVVVVILSILGLVLSDI--------------IEKYFVSPTLLRVVRVAKVGRVL 1725

Zfish  1267 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTF 1331
            :|:...:||||||:....|..||..:.||:.::.||:|:.||..|  :.:.:.:.||...||:||
  Fly  1726 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTF 1788

Zfish  1332 PQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLCAFLI-I 1395
            .|:::|||:.:|...|..::.|.:..:.||| .|.:.|....|||:...|.|:..|::.:||| |
  Fly  1789 GQSMILLFQMSTSAGWDGVLDAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIVI 1852

Zfish  1396 NLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK 1459
            |:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||...|
  Fly  1853 NMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK 1917

Zfish  1460 LCPHRVACKRLVAMNMPLNSDGTVMFNATLF-ALVRTALKIKTEGN-LEQANE--ELRA------ 1514
              |::.   ::::|::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|      
  Fly  1918 --PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEG 1974

Zfish  1515 ---VIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEEG 1565
               |...:|::.                    :.|...|||..:||.|.|.|.|
  Fly  1975 YEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGG 2008

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1daXP_021335251.1 Ion_trans 77..377 CDD:306908 85/328 (26%)
Ion_trans 509..744 CDD:306908 71/295 (24%)
Ion_trans 828..1105 CDD:306908 99/291 (34%)
Ion_trans 1150..1414 CDD:306908 86/268 (32%)
GPHH 1415..1485 CDD:318993 17/69 (25%)
Ca_chan_IQ 1487..1558 CDD:312334 16/83 (19%)
CAC1F_C 1583..2092 CDD:318975
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 80/311 (26%)
Na_trans_cytopl 515..648 CDD:288761 18/132 (14%)
Ion_trans 835..1028 CDD:278921 55/205 (27%)
Na_trans_assoc 1054..1296 CDD:284034 24/245 (10%)
Ion_trans 1318..1571 CDD:278921 96/274 (35%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 81/252 (32%)
GPHH 1880..1930 CDD:293510 14/54 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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