Protein Alignment cacna1da and para

DIOPT Version :10

• Sequence 1: XP_021335251.2
• Gene: cacna1da / 403310
• ZFINID: ZDB-GENE-030616-135
• Length: 2093
• Species: Danio rerio
• Sequence 2: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Alignment Length: 2069
• Identity: 477/2069 - (23%)
• Similarity: 835/2069 - (40%)
• Gaps: 653/2069 - (31%)

Zfish     6 PAPPAATPAAPP-AAAVPVPSVVPVGS------LAQKKR--AQYAKSKKQGSSANTRPQRALFCL 61
            |.|.....:.|| .|:.|:..:.|..|      :..|.:  .:::.||            |::.|
  Fly    84 PIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASK------------AMWML 136

Zfish    62 NLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTI 126
            :..|||||..|.::....|.:||:..|..||:.:.:          .|...:|:.|..|..|:|.
  Fly   137 DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTF 191

Zfish   127 ETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGK 191
            |:.:|::|.|.::....|:|:.||.||||::.:...::.:::            .||:
  Fly   192 ESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDL------------GNLA------- 237

Zfish   192 PGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIG 256
                   |||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||::::|
  Fly   238 -------ALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 295

Zfish   257 KMHASCY----FQG-----TD-------------ILEDE----PAPCAVNGHGRTCPINGTLCKE 295
            .:...|.    ..|     ||             ..|||    |....::|.|: |. :..:|.:
  Fly   296 VLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CD-DDYVCLQ 358

Zfish   296 GW-QGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPW--VYFVSLVIFGSFFV 357
            |: ..||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||::
  Fly   359 GFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYL 420

Zfish   358 LNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLK---------------- 396
            :||:|.:::..:.:.::||:..  .:.:.:||.::        |||...
  Fly   421 VNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAA 485

Zfish   397 --------------GYLDWITQAEDIDPENEEE--------EEES-----------------KRN 422
                          .|..::...:..|..|:|:        |.||                 |..
  Fly   486 LHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVR 550

Zfish   423 RVTLASL--------------MEKK---KKGFGWFS----------------------QSSDTHA 448
            :|:..||              ...|   :.|.|.|.                      .:.|::|
  Fly   551 KVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNA 615

Zfish   449 SMPASE--------------------------------------------------TESMNTENE 463
            ..|.||                                                  ...:...|.
  Fly   616 VTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNT 680

Zfish   464 KGEDEKATCCGPTCQKISKSKFSRRWRRWNRLCR------------------------------- 497
            :.:...||..|.||.. :..|...|.......|.
  Fly   681 RNQSVGATNGGTTCLD-TNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744

Zfish   498 ---------RNCRLAVKSVPFY-------------------------------------WL---- 512
                     |:.|.:.:.|..|                                     ||
  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809

Zfish   513 -VIILVF-------------LNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGL 563
             |.::||             :||:.::.:|::....:.:|....|....|.|..|..:|:.::..
  Fly   810 WVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSP 874

Zfish   564 QAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLL 628
            :.||...:|.||..:|.     ..|:|..:....|:||.|..||||:||:.:.|.:|:.|::.:.
  Fly   875 KYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMG 934

Zfish   629 NSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFN-----FDETQTKRSTFDNFPQALLTVFQILTG 688
            .:|.::.:|..:|.:.|.||:::|||:||..::     |.:....|..|.:|..:.:.||::|.|
  Fly   935 RTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCG 999

Zfish   689 EDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNT----D 748
            | |...|:|.:..       |.:.|| :|:...:.||.::||:|||:.:.|.. :.||:.    :
  Fly  1000 E-WIESMWDCMYV-------GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSLSAPTADN 1055

Zfish   749 DTKKPDEI--------------------------------------------------------- 756
            ||.|..|.
  Fly  1056 DTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCIS 1120

Zfish   757 ------------DEI-------------------------------------------------- 759
                        |||
  Fly  1121 AEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDD 1185

Zfish   760 ---------------EDEAKAGE------EDEKDNAEED-------EEEPDVPAGPRPKISELV- 795
                           :||:..|.      |:::|.::||       :||.:...||..  .:::
  Fly  1186 TASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD--GDIII 1248

Zfish   796 ---------------------KKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFI 839
                                 ||..|....:.|.|  :.....:|:...:||.:..|...::..|
  Fly  1249 HAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPF--WQGWGNLRLKTFQLIENKYFETAVITMI 1311

Zfish   840 MLSSASLAAEDPIRNFSARNI---ILGYFDYAFTAIFTVEIVLKMTTYGAFLH-KGAFCRNYFNL 900
            ::||.:||.||.  :...|.|   ||.|.|..||.||.:|:::|....|..:: ..|:|     .
  Fly  1312 LMSSLALALEDV--HLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC-----W 1369

Zfish   901 LDLLVVGVSLVSFG---IQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIM 962
            ||.::|.|||::|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::
  Fly  1370 LDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVL 1434

Zfish   963 IVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYILYKEGDVNQPIIQKRH-------- 1019
            :|..:...:||.:|||||.||:::|        |:..||.:.::       ||..|:
  Fly  1435 LVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHE-------IIPNRNACESENYT 1484

Zfish  1020 WHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAF 1084
            |.||..|||:|..|.:.||.|:||:||..::..||||...:..||....:.:.::|:.:||..:|
  Fly  1485 WVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSF 1549

Zfish  1085 FMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY----------ALKARPLRRYIPKNPYQY 1139
            |.:|:|:|.:|..|.||.:|...:.|:...:.|...|          .|||.|..|:.|    |.
  Fly  1550 FTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QA 1610

Zfish  1140 KFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKP 1204
            ..:.:|....|:.|:.:.|.||...:.:..|..|:.:|.|:|.||.:|..:|:.|.:||:.|.:
  Fly  1611 IVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR- 1674

Zfish  1205 RHYFTDAWNTFDALIVVGSVVDIAITEVNPTEAPQVDESGNTEDSARISITFFRLFRVM---RLV 1266
            .|||.:.||.||.::|:.|::.:.::::              .:...:|.|..|:.||.   |::
  Fly  1675 YHYFIEPWNLFDVVVVILSILGLVLSDI--------------IEKYFVSPTLLRVVRVAKVGRVL 1725

Zfish  1267 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTF 1331
            :|:...:||||||:....|..||..:.||:.::.||:|:.||..|  :.:.:.:.||...||:||
  Fly  1726 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTF 1788

Zfish  1332 PQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLCAFLI-I 1395
            .|:::|||:.:|...|..::.|.:..:.||| .|.:.|....|||:...|.|:..|::.:||| |
  Fly  1789 GQSMILLFQMSTSAGWDGVLDAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIVI 1852

Zfish  1396 NLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK 1459
            |:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||...|
  Fly  1853 NMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK 1917

Zfish  1460 LCPHRVACKRLVAMNMPLNSDGTVMFNATLF-ALVRTALKIKTEGN-LEQANE--ELRA------ 1514
              |::.   ::::|::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|
  Fly  1918 --PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEG 1974

Zfish  1515 ---VIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEEG 1565
               |...:|::.                    :.|...|||..:||.|.|.|.|
  Fly  1975 YEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGG 2008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cacna1da	XP_021335251.2	None
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	84/324 (26%)
		Na_trans_cytopl	555..740	CDD:463401	20/185 (11%)
		Ion_trans	817..1028	CDD:459842	57/223 (26%)
		Na_trans_assoc	1054..1296	CDD:461936	24/245 (10%)
		Ion_trans	1300..1571	CDD:459842	100/292 (34%)
		Na_channel_gate	1561..1613	CDD:240441	14/55 (25%)
		Ion_trans	1621..1871	CDD:459842	86/267 (32%)
		GPHH	1882..1929	CDD:465306	13/51 (25%)