DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ICA69 and Ica1

DIOPT Version :9

Sequence 1:	NP_001246855.1	Gene:	ICA69 / 40331	FlyBaseID:	FBgn0037050	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_110471.2	Gene:	Ica1 / 81024	RGDID:	621465	Length:	480	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	163/456 - (35%)
Similarity:	227/456 - (49%)	Gaps:	74/456 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEVQHQFWITKKVVQRKLGTKEDKHIISSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILS 68
            :::|.::|.||:...:..|.|||:|:::|||:||:|:|:|.||..|.|:|.|.|..||:|:|.||
  Rat    23 NKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLS 87

  Fly    69 QEECVFGRFLKEAGKRSRTTGGSIAH-TAKAVSFAGQQRMCVRVPLLRLQHEVDVFRCRAIKDTE 132
            |||...|:||:..|.:.:|..|.:.. |.||:.|:.|||:.:|.||.|...||:.||.|||.||.
  Rat    88 QEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTW 152

  Fly   133 QTLQTMEKERTEYRAALSWMKSASQELDPDTGKGLDKFRTAQAHVRVAKHNFDGYSMDSIQKIDL 197
            .|:..||:.|||||.||.|||..|||||||..|.::|||..|..||:||.|||...||..||:||
  Rat   153 LTVNRMEQCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDL 217

  Fly   198 LAAARCNMYSHALVAYVTELKNFAQKAASTFQTISKALIIKPKYDFCVLKEL----------SQN 252
            |.|:|||:.||.|..|.|.|.:|.:|.:.|...|.::......|:|..||.|          .:.
  Rat   218 LGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEKK 282

  Fly   253 EGSTEEVPPIEAVDKDQSLFFANEYQDKLETQPEIKE-----SEEDKPSA--------------- 297
            :.|..|.....|.:..|.:....|.|.|..:..:.:|     |..||.||
  Rat   283 KSSRRENREAVAQEPRQLISLEEENQHKESSTCQTEEGKSVPSSVDKSSADDACSGPIDELLDVK 347

  Fly   298 PPNAC------------GDNESLLIELSKQLEDSPLIDAPLDEDIPAQNSTNKLWSRLFSQQN-Q 349
            |..||            ||.:.||: |::....|.|.:.....:          |:.:|.... :
  Rat   348 PEEACLGPMAGTPEPESGDKDDLLL-LNEIFSTSSLDEGEFSRE----------WAAVFGDDRLK 401

  Fly   350 QPIP--SQVATDSKASAGGA-----------------TPVPSKSQTTNNPWLDLFADLDPLANPQ 395
            :|.|  :|...|.|...|.|                 ...|:|:.:....|..||||||||:||.
  Rat   402 EPAPMGAQGEPDPKPQIGSAFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPD 466

  Fly   396 A 396
            |
  Rat   467 A 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICA69	NP_001246855.1	BAR_ICA69	33..235	CDD:153345	102/202 (50%)
ICA69	NP_001246855.1	ICA69	<345..396	CDD:282483	20/70 (29%)
Ica1	NP_110471.2	BAR_ICA69	52..255	CDD:153345	102/202 (50%)
		ICA69	260..480	CDD:282483	51/219 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..338		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..421		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353342
Domainoid	1	1.000	219	1.000	Domainoid score	I2558
eggNOG	1	0.900	-	-		E1_KOG3891
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3176
OMA	1	1.010	-	-		QHG50078
OrthoDB	1	1.010	-	-		D334210at33208
OrthoFinder	1	1.000	-	-		FOG0003439
OrthoInspector	1	1.000	-	-		otm45647
orthoMCL	1	0.900	-	-		OOG6_107584
Panther	1	1.100	-	-	LDO	PTHR10164
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2807
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770