DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ICA69 and ica1

DIOPT Version :9

Sequence 1:	NP_001246855.1	Gene:	ICA69 / 40331	FlyBaseID:	FBgn0037050	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_012820195.2	Gene:	ica1 / 549616	XenbaseID:	XB-GENE-974152	Length:	530	Species:	Xenopus tropicalis

Alignment Length:	503	Identity:	174/503 - (34%)
Similarity:	243/503 - (48%)	Gaps:	121/503 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEVQHQFWITKKVVQRKLGTKEDKHIISSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILS 68
            :::|.::|.||:.:.:..|.|||:|:::||::||:|:|:|.||..|.:.|.|:|:|||:|:|.||
Frog    26 NKMQQKYWKTKQTLIKVTGKKEDEHVVASDSDLDAKLELFHSIQRTCMELLKVIEQYQKRICFLS 90

  Fly    69 QEECVFGRFLKEAGKRSRTTGGSIAH-TAKAVSFAGQQRMCVRVPLLRLQHEVDVFRCRAIKDTE 132
            |||...|:||:..|.:.:|..|.|.. |.||:.|:.|||:.:|.||.||..||:.||.|||.|:.
Frog    91 QEENELGKFLRSQGSQDKTRAGKIMQATGKALCFSSQQRLALRSPLSRLHQEVETFRYRAISDSW 155

  Fly   133 QTLQTMEKERTEYRAALSWMKSASQELDPDTGKGLDKFRTAQAHVRVAKHNFDGYSMDSIQKIDL 197
            .|:..||:.|||||..|.|||..||||||||.|.::|||..||.||..|..||....|..:|:||
Frog   156 LTVNRMEQSRTEYRGVLLWMKDVSQELDPDTYKQMEKFRKVQAQVRHTKAAFDRLKTDVCEKVDL 220

  Fly   198 LAAARCNMYSHALVAYVTELKNFAQKAASTFQTISKALIIKPKYDFCVLKELSQNEGSTEEVPPI 262
            |.|:|||:.||.|..|.|.|.:|.:|.:.|...|.::......|:|..||..::..|::    |.
Frog   221 LRASRCNLLSHVLTTYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKPNNRKPGAS----PC 281

  Fly   263 EAVDKDQSLFFANEYQDKLETQPEIKESEEDKPSAPPNACGDNESLLIELSKQLEDSP------- 320
            .|   .|||   .:..|||..|.| :|.|::|....|....|:|.:.:|..||...||
Frog   282 SA---GQSL---QDPVDKLIQQQE-EEEEKNKSKDDPAVKPDDELISLEDMKQATGSPGEANIGN 339

  Fly   321 ------------------LIDA---------------PLD------------EDIPAQNS----- 335
                              |:|.               |||            .||.:.:|
Frog   340 LSSFEDILRENSVGAMDDLLDLKPDEKMFYGETVPKDPLDPDTGDKDEIQLLNDILSASSLEGDD 404

  Fly   336 TNKLWSRLFSQ--QNQQPI------------------PSQV---------------ATDSKASAG 365
            ..|.|:.:|..  .|..|:                  |||:               ..:|..||.
Frog   405 LGKEWAAVFGDPLPNPHPVSPGATDMEQHADSSAGFLPSQLLDQDMNDLLSSLHGWTANSGTSAS 469

  Fly   366 GATPVPSK-SQTTN---------NP-------WLDLFADLDPLANPQA 396
            .|.|.||. :.:||         ||       |.:||||||||:||.|
Frog   470 QAAPPPSSLNSSTNKAPAKDGSKNPGSKDLSAWYNLFADLDPLSNPDA 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICA69	NP_001246855.1	BAR_ICA69	33..235	CDD:153345	99/202 (49%)
ICA69	NP_001246855.1	ICA69	<345..396	CDD:282483	27/102 (26%)
ica1	XP_012820195.2	BAR_ICA69	55..258	CDD:153345	99/202 (49%)
ica1	XP_012820195.2	ICA69	264..530	CDD:398355	65/265 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2580
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3304
OMA	1	1.010	-	-		QHG50078
OrthoDB	1	1.010	-	-		D334210at33208
OrthoFinder	1	1.000	-	-		FOG0003439
OrthoInspector	1	1.000	-	-		oto104127
Panther	1	1.100	-	-	LDO	PTHR10164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2749
SonicParanoid	1	1.000	-	-		X2807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110