DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ICA69 and ica1

DIOPT Version :9

Sequence 1:	NP_001246855.1	Gene:	ICA69 / 40331	FlyBaseID:	FBgn0037050	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001002730.1	Gene:	ica1 / 437003	ZFINID:	ZDB-GENE-040718-490	Length:	449	Species:	Danio rerio

Alignment Length:	446	Identity:	168/446 - (37%)
Similarity:	229/446 - (51%)	Gaps:	63/446 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEVQHQFWITKKVVQRKLGTKEDKHIISSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILS 68
            ::.|.::|.||:.:.:..|.|||:|:::|||:||:|:|||.|:..|.:.|.|:|:|||.|:.:||
Zfish    21 NKFQQKYWKTKQTLIKVTGKKEDEHVVASDADLDAKLEVFHSVQRTCMELLKVIEQYQRRISLLS 85

  Fly    69 QEECVFGRFLKEAGKRSRTTGGSIAH-TAKAVSFAGQQRMCVRVPLLRLQHEVDVFRCRAIKDTE 132
            |||...||||:..|.:.::..|.|.. |.||:.|:.|||:.:|.||.||..||:.||.|||.||.
Zfish    86 QEENELGRFLRSQGSQDKSRAGKIMQATGKALCFSSQQRLALRGPLGRLYQEVETFRYRAISDTW 150

  Fly   133 QTLQTMEKERTEYRAALSWMKSASQELDPDTGKGLDKFRTAQAHVRVAKHNFDGYSMDSIQKIDL 197
            .|:..||:.|||||.||.|||..||||||||.|.::|||..|..||..|.:||....|..||:||
Zfish   151 LTVNRMEQSRTEYRGALLWMKDVSQELDPDTHKQMEKFRKVQTQVRHTKTSFDKLKNDVCQKVDL 215

  Fly   198 LAAARCNMYSHALVAYVTELKNFAQKAASTFQTISKALIIKPKYDFCVLKELSQNEGSTEEVPPI 262
            |.|:|||:.||.|..|.|.|.:|.:|.:.|...|.::      :..|...|.|  .||.
Zfish   216 LGASRCNLLSHVLTTYQTTLLHFWEKTSHTMAAIHES------FKGCQTHETS--AGSD------ 266

  Fly   263 EAVDKDQSLFFANEYQDKLETQPEIKES----EEDKPSAPPNACGDNE------SLLIEL--SKQ 315
            :||.|........:..|  ||.|...|:    |::..|:.....|.:|      |||.|:  |..
Zfish   267 QAVKKKMKKKSKAKTDD--ETSPATDETLISLEQETQSSNTTHTGADEGLSDGLSLLDEILGSSS 329

  Fly   316 LEDSPLIDA-----PLDEDIPAQNSTNK----------LWSRLFSQQNQQPIPSQVA-------- 357
            |||......     ..|||:...|....          |.|:|. .||...:.|.|:
Zfish   330 LEDGGFSQEWREVFGEDEDLSCSNGAETQTTDEEADFFLPSKLL-DQNMNNLQSTVSGSLSAILQ 393

  Fly   358 ----TDSKASAGGATPVPSKSQTTNNPWLDLFADLDPLANPQAFDLKLSGGRSVAE 409
                :.|.|....:.|..::|....:.|..|||||||||||.|.      |||.|:
Zfish   394 NNPGSSSVAGQNSSKPAVNESSKDLSAWFSLFADLDPLANPDAI------GRSGAD 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICA69	NP_001246855.1	BAR_ICA69	33..235	CDD:153345	101/202 (50%)
ICA69	NP_001246855.1	ICA69	<345..396	CDD:282483	20/62 (32%)
ica1	NP_001002730.1	BAR_ICA69	50..253	CDD:153345	101/208 (49%)
ica1	NP_001002730.1	ICA69	289..449	CDD:282483	45/162 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3177
OMA	1	1.010	-	-		QHG50078
OrthoDB	1	1.010	-	-		D334210at33208
OrthoFinder	1	1.000	-	-		FOG0003439
OrthoInspector	1	1.000	-	-		otm25850
orthoMCL	1	0.900	-	-		OOG6_107584
Panther	1	1.100	-	-	LDO	PTHR10164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2749
SonicParanoid	1	1.000	-	-		X2807
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010