Protein Alignment ICA69 and ICA1

DIOPT Version :10

• Sequence 1: NP_649283.1
• Gene: ICA69 / 40331
• FlyBaseID: FBgn0037050
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: XP_024302508.1
• Gene: ICA1 / 3382
• HGNCID: 5343
• Length: 569
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 163/484 - (33%)
• Similarity: 231/484 - (47%)
• Gaps: 99/484 - (20%)

  Fly     4 SEVQHQFWITKKVVQRKLGTKEDKHIISSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILS 68
            :::|.::|.||:...:..|.|||:|:::|||:||:|:|:|.||..|.|:|.|.|..||:|:|.||
Human    81 NKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLS 145

  Fly    69 QEECVFGRFLKEAGKRSRTTGGSIAH-TAKAVSFAGQQRMCVRVPLLRLQHEVDVFRCRAIKDTE 132
            |||...|:||:..|.:.:|..|.:.. |.||:.|:.|||:.:|.||.|...||:.||.|||.||.
Human   146 QEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTW 210

  Fly   133 QTLQTMEKERTEYRAALSWMKSASQELDPDTGKGLDKFRTAQAHVRVAKHNFDGYSMDSIQKIDL 197
            .|:..||:.|||||.||.|||..|||||||..|.::|||..|..||:||.|||...||..||:||
Human   211 LTVNRMEQCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDL 275

  Fly   198 LAAARCNMYSHALVAYVTELKNFAQKAASTFQTISKALIIKPKYDFCVLKEL---------SQNE 253
            |.|:|||:.||.|..|.|.|.:|.:|.:.|...|.::......|:|..||.|         .:.:
Human   276 LGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEEK 340

  Fly   254 GSTEEVPPIEAVDKDQSLFFAN------------------EYQD-----KLETQPEIKESEEDKP 295
            ....:....:|..::.|.:..|                  |.|.     .||.:.:.|||...|.
Human   341 KKINQQESTDAAVQEPSQYLQNICLEMKANSDIKMLQKGKEGQQIGILISLEEENQRKESSSFKT 405

  Fly   296 SAPPNACGDNESLLIELSKQLEDSPLIDAPLDE--DIPAQNST---------------------- 336
            .       |.:|:|..|.|. ........|:||  |:.::...
Human   406 E-------DGKSILSALDKG-STHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLL 462

  Fly   337 --------------NKLWSRLFSQ-QNQQPIPSQV--ATDSKASAG-GATP-------------- 369
                          :|.|:.:|.. |.::|:|:..  ..|.||..| |..|
Human   463 SEIFNASSLEEGEFSKEWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQAS 527

  Fly   370 --VPSKSQTTNNPWLDLFADLDPLANPQA 396
              .|:|:.:....|..||||||||:||.|
Human   528 LQEPAKAASDLTAWFSLFADLDPLSNPDA 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ICA69	NP_649283.1	BAR_ICA69	33..235	CDD:153345	102/202 (50%)
		ICA69	<345..396	CDD:461374	22/70 (31%)
ICA1	XP_024302508.1	BAR_ICA69	110..313	CDD:153345	102/202 (50%)
		ICA69	318..569	CDD:461374	51/247 (21%)