DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ICA69 and Ica1

DIOPT Version :9

Sequence 1:	NP_001246855.1	Gene:	ICA69 / 40331	FlyBaseID:	FBgn0037050	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_034622.3	Gene:	Ica1 / 15893	MGIID:	96391	Length:	478	Species:	Mus musculus

Alignment Length:	454	Identity:	160/454 - (35%)
Similarity:	229/454 - (50%)	Gaps:	72/454 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEVQHQFWITKKVVQRKLGTKEDKHIISSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILS 68
            :::|.::|.||:...:..|.|||:|:::|||:||:|:|:|.||..|.|:|.|.|..||:|:|.||
Mouse    23 NKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLS 87

  Fly    69 QEECVFGRFLKEAGKRSRTTGGSIAH-TAKAVSFAGQQRMCVRVPLLRLQHEVDVFRCRAIKDTE 132
            |||...|:||:..|.:.:|..|.:.. |.||:.|:.|||:.:|.||.|...||:.||.|||.||.
Mouse    88 QEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTW 152

  Fly   133 QTLQTMEKERTEYRAALSWMKSASQELDPDTGKGLDKFRTAQAHVRVAKHNFDGYSMDSIQKIDL 197
            .|:..||:.|||||.||.|||..|||||||..|.::|||..|..||:||.|||...||..||:||
Mouse   153 LTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDL 217

  Fly   198 LAAARCNMYSHALVAYVTELKNFAQKAASTFQTISKALIIKPKYDFCVLKELS-------QNEG- 254
            |.|:|||:.||.|..|.|.|.:|.:|.:.|...|.::......|:|..||.|.       :.||
Mouse   218 LGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGK 282

  Fly   255 ------STEEVPP-------IEAVDKDQSLFFANEYQDKLETQPE----------IKESEEDKP- 295
                  :.|.|.|       :|...||.|.:...|....|.:..:          |.|..:.||
Mouse   283 KTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPE 347

  Fly   296 --------SAPPNACGDNESLLIELSKQLEDSPLIDAPLDEDIPAQNSTNKLWSRLF-SQQNQQP 351
                    ..|....||.:.||  |..::..:..:|         :...::.|:.:| ..|.::|
Mouse   348 EACLGPTAGTPEPESGDKDDLL--LLNEIFSTSCLD---------EGEFSREWAAVFGDDQLKEP 401

  Fly   352 -------------------IPSQVATDSKASAGGATPVPSKSQTTNNPWLDLFADLDPLANPQA 396
                               :|||:...:......:...|:|:.:....|..||||||||:||.|
Mouse   402 APMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDA 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICA69	NP_001246855.1	BAR_ICA69	33..235	CDD:153345	102/202 (50%)
ICA69	NP_001246855.1	ICA69	<345..396	CDD:282483	18/69 (26%)
Ica1	NP_034622.3	BAR_ICA69	52..255	CDD:153345	102/202 (50%)
		ICA69	260..478	CDD:368030	48/217 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..365		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..422		1/23 (4%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849684
Domainoid	1	1.000	220	1.000	Domainoid score	I2605
eggNOG	1	0.900	-	-		E1_KOG3891
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3259
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50078
OrthoDB	1	1.010	-	-		D334210at33208
OrthoFinder	1	1.000	-	-		FOG0003439
OrthoInspector	1	1.000	-	-		otm43576
orthoMCL	1	0.900	-	-		OOG6_107584
Panther	1	1.100	-	-	LDO	PTHR10164
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770