Protein Alignment ICA69 and ICA1L

DIOPT Version :10

• Sequence 1: NP_649283.1
• Gene: ICA69 / 40331
• FlyBaseID: FBgn0037050
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_612477.3
• Gene: ICA1L / 130026
• HGNCID: 14442
• Length: 482
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 162/462 - (35%)
• Similarity: 224/462 - (48%)
• Gaps: 80/462 - (17%)

  Fly     6 VQHQFWITKKVVQRKLGTKEDKHIISSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILSQE 70
            :|.::|.||:|..:..|.|||:|:::||||||:|:|||.|:.:|...|.|||::||.||.::|:|
Human    19 MQKKYWKTKQVFIKATGKKEDEHLVASDAELDAKLEVFHSVQETCTELLKIIEKYQLRLNVISEE 83

  Fly    71 ECVFGRFLKEAGKRSRTTGGSIAH-TAKAVSFAGQQRMCVRVPLLRLQHEVDVFRCRAIKDTEQT 134
            |...|.|||...:|..|..|.:.. |.||:..:.:||:.:..||.||:.||..|..||:.||..|
Human    84 ENELGLFLKFQAERDATQAGKMMDATGKALCSSAKQRLALCTPLSRLKQEVATFSQRAVSDTLMT 148

  Fly   135 LQTMEKERTEYRAALSWMKSASQELDPDTGKGLDKFRTAQAHVRVAKHNFDGYSMDSIQKIDLLA 199
            :..||:.|||||.||.|||..||||||||.|.::|||..|..||.:|.:||...||..||:|||.
Human   149 INRMEQARTEYRGALLWMKDVSQELDPDTLKQMEKFRKVQMQVRNSKASFDKLKMDVCQKVDLLG 213

  Fly   200 AARCNMYSHALVAYVTELKNFAQKAASTFQTISKALIIKPKYDFCVLKELSQNEGS--------- 255
            |:||||.||:|..|...|..|.:|.|.....|.:|.|....|||..||:|......
Human   214 ASRCNMLSHSLTTYQRTLLGFWKKTARMMSQIHEACIGFHPYDFVALKQLQDTPSKISEDNKDEQ 278

  Fly   256 -----TEEVPPIEAVDKDQSLFFANEYQDKLETQ----------PEIKESE---EDKP------- 295
                 ||::..:...|::.|  |.:|..:|...:          |:...||   :|.|
Human   279 IGGFLTEQLNKLVLSDEEAS--FESEQANKDHNEKHSQMREFGAPQFSNSENVAKDLPVDSLEGE 341

  Fly   296 ------SAPPNACGDNESLLIELSKQLE---DSPLIDAPLDE----DIPAQNSTNKLWSRLF--- 344
                  |...|......|...|.:::.:   .||.......|    ..|..:|:..|.|:||
Human   342 DFEKEFSFLNNLLSSGSSSTSEFTQECQTAFGSPSASLTSQEPSMGSEPLAHSSRFLPSQLFDLG 406

  Fly   345 --------------------SQQNQQPIPSQVATDSKASAGGATPVPSKSQTTNNPWLDLFADLD 389
                                |..:.||:|||       |....|..|:......:.|.:||||||
Human   407 FHVAGAFNNWVSQEESELCLSHTDNQPVPSQ-------SPKKLTRSPNNGNQDMSAWFNLFADLD 464

  Fly   390 PLANPQA 396
            ||:||.|
Human   465 PLSNPDA 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ICA69	NP_649283.1	BAR_ICA69	33..235	CDD:153345	97/202 (48%)
		ICA69	<345..396	CDD:461374	20/50 (40%)
ICA1L	NP_612477.3	BAR_ICA69	46..248	CDD:153345	97/201 (48%)
		ICA69	254..482	CDD:461374	52/227 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..393		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..449		9/28 (32%)