Protein Alignment ko and STOX2

DIOPT Version :10

• Sequence 1: NP_524193.2
• Gene: ko / 40330
• FlyBaseID: FBgn0020294
• Length: 1049
• Species: Drosophila melanogaster
• Sequence 2: NP_064610.1
• Gene: STOX2 / 56977
• HGNCID: 25450
• Length: 926
• Species: Homo sapiens
• Alignment Length: 1031
• Identity: 226/1031 - (21%)
• Similarity: 340/1031 - (32%)
• Gaps: 304/1031 - (29%)

  Fly    93 AFARSVLKPPATYVISSVGDIDDCIVTPTVQGQFTPLPEALCDVIMDLTAEGQSATIEHVRSKLG 157
            |||     |.|:....:.||:....::|..|.||.||.|.||..|..:.:..:..|.|.:...|.
Human    43 AFA-----PQASRGYMTSGDVSPISMSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLT 102

  Fly   158 SRFPHMTTPATEVIYDSLAQLMQEQKIYQTSKGYFIFTPERRRSRSRPRSNHHQLNGSLAYGHLA 222
            :.||.:.||:.|::..:|..|::|:|||.|..||||.||:                   .|
Human   103 TCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQ-------------------TY---- 144

  Fly   223 EEEQQHGDDVVPQEARTMLMSNSEALHSLYGEISTERDGDLTHQCIQTNLADVICGGNPNDKIIY 287
                    .:.|...||    ||:..|      ..||..|.: ||.           :|....|.
Human   145 --------FITPSLIRT----NSKWYH------LDERIPDRS-QCT-----------SPQPGTIT 179

  Fly   288 PRAAKRRSASFPTPRSLERRHSLRLFGSSKRLQRCASTR-SLSKTYAQTLN-------------- 337
            |.|     :.....|:|.|.|          ...|...| .:..|:|.||.
Human   180 PSA-----SGCVRERTLPRNH----------CDSCHCCREDVHSTHAPTLQRKSAKDCKDPYCPP 229

  Fly   338 ------TTDSSSS----EYQSTDSSSPKKGSLLS-----RLFRRS-GRAKQRQIETYSAQFPPAE 386
                  .|:.|.|    .|::...|.||.....|     :|||.| .:.|.:|:..:||||||.|
Human   230 SLCQVPPTEKSKSTVNFSYKTETLSKPKDSEKQSKKFGLKLFRLSFKKDKTKQLANFSAQFPPEE 294

  Fly   387 W--------------------------FNTRAVHLHSVGTQTAEHDMPVAHTLSNSTFYDGSELS 425
            |                          .....|..|:...:..|.:........:|..:.|.  |
Human   295 WPLRDEDTPATIPREVEMEIIRRINPDLTVENVMRHTALMKKLEEEKAQRSKAGSSAHHSGR--S 357

  Fly   426 QRSSTLPRRHRRHMSSESTFLISSRD-----------------CSPIRRRSPVYCSSSLPRSTQS 473
            ::|.|..:.|.:..|...| .:|..|                 |.|:.|         :||....
Human   358 KKSRTHRKSHGKSRSHSKT-RVSKGDPSDGSHLDIPAEREYDFCDPLTR---------VPREGCF 412

  Fly   474 IPATTAKTNHSSRLSHGHGGSVTPTPPKTAQKSVIG---KHIFE---SSPSR-SATLKATAAKRH 531
            |    .:....:.:.|.:...:....|.|.:..|.|   |...|   ..||| |:..|...:..|
Human   413 I----IEHKGDNFIMHSNTNVLESHFPMTPEWDVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSH 473

  Fly   532 TDGLIINSCLDNKATYRSL---QSSGPSSLESCKTTSMLASG-------PSS--IDSGKVSFSQK 584
            |......:...|||..||.   .|.||....|..|...||.|       ||.  ||...:..:|.
Human   474 TQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGTPEDLAEGCSQDDQTPSQSYIDDSTLRPAQT 538

  Fly   585 TS---GHSSLDSQCSTNTAVIAPP---SNSNNGSSRSILLLNGSPRGTPRHQAMRARVAEAQAQR 643
            .|   .|.|     ||:...:..|   |.|...||...||..|.|   |.
Human   539 VSLQRAHIS-----STSYKEVCIPEIVSGSKEPSSACSLLEPGKP---PE--------------- 580

  Fly   644 QRASTPSRIMEEIYPAGGSNGVPTSNSNNSITLQVTTSNGNQSIPSTKIFVQNSPVRSVITLENG 708
               |.||        .|..|..||..:.:.. .|..||       |..:....||:        |
Human   581 ---SLPS--------YGELNSCPTKTATDDY-FQCNTS-------SETVLTAPSPL--------G 618

  Fly   709 KMLENSNVFIINNETMTNEKGEIIKKTLSKQTSAAPAATSTPV-KPETVSEQPLSETEANSETCD 772
            |..|       :::|:|..:|  :|| ||......|.::..|| ..|...:.|.....|:....:
Human   619 KNKE-------DHDTLTLAEG--VKK-LSPSDRQVPHSSREPVGHKEESPKGPGGGPAASGGVAE 673

  Fly   773 SIS---FISECSPESTCAVEPETPVYDGGKYAKNTNNDATMNNSRKLCLQLANGIAYKNNVLKNE 834
            .|:   .:.....|.: :::....::......|..::..::|:..|..|.|.            :
Human   674 GIANGRLVQHHGAEPS-SLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLL------------K 725

  Fly   835 SQPNSPSADAPLK---------------MAALAKQDFEIAGSVGNLNFYEKSSKDVGASQSNNMM 884
            |.|.:|:...|.:               |.|..:|.........:.::|..|..|.....:|
Human   726 SHPKTPADTLPGRCEKLEPSLGTSAAQAMPASQRQQESGGNQEASFDYYNVSDDDDSEEGAN--- 787

  Fly   885 MNSSTDLKNLCYESVCQLQKCSMNGDELALAHLLHKSSNPLG-----SEPNLALKDLANDKSIDK 944
             .::.:.||  .|.|..:|.......|..|.....|:...|.     |..|......|...|:|.
Human   788 -KNTEEEKN--REDVGTMQWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATHSARLDSMDS 849

  Fly   945 EAI--DRRLS--LTKESLEQGMGSVLANGGEELYNFPSLTDL------SFNFTSLA 990
            .:|  |...:  .|:|||.....|::.:...:   .|:|:..      :|||.:.|
Human   850 SSITVDSGFNSPRTRESLASNTSSIVESNRRQ---NPALSPAHGGAGPAFNFRASA 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ko	NP_524193.2	Stork_head	118..196	CDD:431182	29/77 (38%)
STOX2	NP_064610.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		Stork_head	63..141	CDD:431182	29/77 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..391		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..529		23/76 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..588		11/52 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..672		11/42 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..803		15/96 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	825..926		19/81 (23%)