DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ko and STOX1

DIOPT Version :9

Sequence 1:	NP_001262135.1	Gene:	ko / 40330	FlyBaseID:	FBgn0020294	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001123633.1	Gene:	STOX1 / 219736	HGNCID:	23508	Length:	989	Species:	Homo sapiens

Alignment Length:	1076	Identity:	227/1076 - (21%)
Similarity:	358/1076 - (33%)	Gaps:	313/1076 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRLILQRCLAIQLTKPGHTPEDFWMYDSGYMIFQNFLAANAQCWWNGPLTAATRALKYAGHVAPG 76
            |||..|:. |....:||           |..:|:.|..|||:|:||..|..|...|.:.|.:..|
Human    17 CRLEAQKA-AGAAEEPG-----------GRAVFRAFRRANARCFWNARLARAASRLAFQGWLRRG 69

  Fly    77 MLLVTAEPCALEVLRGAFARSVLKPPATYVISSVGDIDDCIVTPTVQGQFTPLPEALCDVIMDLT 141
            :|||.|.|..|:|||.|:.|..|:||..:.|.:|||:....:.|..|.||.||.|.||..|.|:.
Human    70 VLLVRAPPACLQVLRDAWRRRALRPPRGFRIRAVGDVFPVQMNPITQSQFVPLGEVLCCAISDMN 134

  Fly   142 AEGQSATIEHVRSKLGSRFPHMTTPATEVIYDSLAQLMQEQKIYQTSKGYFIFTPE--------- 197
            ......|.|.:..:|...:|.:..|:.:::|.:|..|::|:|||.|.:||||.||:
Human   135 TAQIVVTQESLLERLMKHYPGIAIPSEDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTT 199

  Fly   198 RRRSRSRPRSNHHQLNGSLAYGHLAEEEQQHGDDVVPQEARTMLMSNSEALHSLYGEISTERDGD 262
            :...|..|......:..|:.|             :|..|:              ..|.:.|....
Human   200 QENKRMLPSDESRLMPASMTY-------------LVSMES--------------CAESAQENAAP 237

  Fly   263 LTH----QCIQ-TNLADVICGGNPNDKIIYPRAAKRRSASFPTPRSLERRHSLRLFGSSKRLQRC 322
            ::|    ||.: .:..||                    ...|....:.|:
Human   238 ISHCQSCQCFRDMHTQDV--------------------QEAPVAAEVTRK--------------- 267

  Fly   323 ASTRSLSKTYAQTLNTTDSSSSEYQSTDSSSP-------KKG-----SLLSRLFRRSGRAKQRQI 375
             |.|.|.::.:...|...|.|:|:...:|:.|       :||     |||.|...|..:.|...
Human   268 -SHRGLGESVSWVQNGAVSVSAEHHICESTKPLPYTRDKEKGKKFGFSLLWRSLSRKEKPKTEH- 330

  Fly   376 ETYSAQFPPAEWFNTRAVHLHSVGTQTAEH------------DMPVAHTLSNSTFYDGSEL-SQR 427
            .::||||||.||.......|.:: .:..||            |..:.||:....:.:..:. ||.
Human   331 SSFSAQFPPEEWPVRDEDDLDNI-PRDVEHEIIKRINPILTVDNLIKHTVLMQKYEEQKKYNSQG 394

  Fly   428 SST--------LPRRH----RRHMSSESTFL-ISSRDCSPIRRRSPVYCSSSL-----PR--STQ 472
            :||        .|.:.    |:.:|::.... .|.||....|.:...:...|:     |:  :||
Human   395 TSTDMLTIGHKYPSKEGVKKRQGLSAKPQGQGHSRRDRHKARNQGSEFQPGSIRLEKHPKLPATQ 459

  Fly   473 SIP----------------ATTAKTNH-----------------SSRLSHGHGGSVTP--TPPKT 502
            .||                .||...:|                 .|.:|.||....|.  .|.:|
Human   460 PIPRIKSPNEMVGQKPLGEITTVLGSHLIYKKRISNPFQGLSHRGSTISKGHKIQKTSDLKPSQT 524

  Fly   503 AQK--------SVIGKHIFESSPSRSATLKATAAKRHTDGLIINSCLDNKATYRSLQSSGPSSLE 559
            ..|        |:....||:..      .|...|::..|.:...|...|..|.:.:.......|.
Human   525 GPKEKPFQKPRSLDSSRIFDGK------AKEPYAEQPNDKMEAESIYINDPTVKPINDDFRGHLF 583

  Fly   560 SCKTTSMLASGPSSIDSGKVSFSQK------------------TSGHSSLDSQCSTNTAVIAPPS 606
            |....|||.:     |.....|.:.                  ...||..|....|.....:.||
Human   584 SHPQQSMLQN-----DGKCCPFMESMLRYEVYGGENEVIPEVLRKSHSHFDKLGETKQTPHSLPS 643

  Fly   607 NSNNGSSRSILLLNGSPRGTPR---------HQAMRARVAE--------AQAQRQRASTPSRIME 654
            ...:.|.|           ||.         ||.....:.:        .||.||     .:..|
Human   644 RGASFSDR-----------TPSACRLVDNTIHQFQNLGLLDYPVGVNPLRQAARQ-----DKDSE 692

  Fly   655 EIYPAGGSNGVPTSNSNNSITLQVTTSNGNQSIPSTKIFVQNSPVRSVITLENGKMLENSNV--- 716
            |:...|......|::..|.     ..||.:|::...:: ..:....|.:.||...:.||.::
Human   693 ELLRKGFVQDAETTSLENE-----QLSNDDQALYQNEV-EDDDGACSSLYLEEDDISENDDLRQM 751

  Fly   717 ------FIINNETMTNEKG--EIIKKTLSKQTSAAPAATSTPV------KPETVSEQPLSETEAN 767
                  :.....:..|..|  ::|:::|::..|......|..:      ||..:...|....|.|
Human   752 LPGHSQYSFTGGSQGNHLGKQKVIERSLTEYNSTMERVESQVLKRNECYKPTGLHATPGESQEPN 816

  Fly   768 --SETCD-----SISFISECSPESTCAVEPETP------------------------VYDGGKYA 801
              :|:|.     ...|..|..|.....|:...|                        :.|.||..
Human   817 LSAESCGLNSGAQFGFNYEEEPSVAKCVQASAPADERIFDYYSARKASFEAEVIQDTIGDTGKKP 881

  Fly   802 KNTNNDATMNNSRKLCLQ------------LANGIAYKNNVL---KNESQPNSPSADAPLKMAAL 851
            .:.:........||...|            ||..:.|:::.|   :|.|.......|:|...:..
Human   882 ASWSQSPQNQEMRKHFPQKFQLFNTSHMPVLAQDVQYEHSHLEGTENHSMAGDSGIDSPRTQSLG 946

  Fly   852 AKQDFEIAGSVGNLNFYEKSSKDVGASQSNNMMMNS 887
            :.....:.|.....||.:...   |...|..:..||
Human   947 SNNSVILDGLKRRQNFLQNVE---GTKSSQPLTSNS 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ko	NP_001262135.1	Stork_head	119..195	CDD:287266	28/75 (37%)
STOX1	NP_001123633.1	Stork_head	112..188	CDD:287266	28/75 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346		9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..470		17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..556		13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..651		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	926..948		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158105
Domainoid	1	1.000	66	1.000	Domainoid score	I9981
eggNOG	1	0.900	-	-		E1_KOG3897
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006082
OrthoInspector	1	1.000	-	-		otm42047
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22437
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3228
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.960