Protein Alignment siz and Arfgef2

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001078964.1
• Gene: Arfgef2 / 99371
• MGIID: 2139354
• Length: 1792
• Species: Mus musculus
• Alignment Length: 790
• Identity: 183/790 - (23%)
• Similarity: 291/790 - (36%)
• Gaps: 223/790 - (28%)

  Fly   342 TIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQ 406
            |::..:..|:..|...:.|. |||.......::.|                   ..|:|:.::.:
Mouse   162 TVRTCYNIYLASKNLINQTT-AKATLTQMLNVIFT-------------------RMENQVLQEAR 206

  Fly   407 QQQAQQQQQPRVTIMAGPAGAASPGLSR-----------TPPTRSLSMRERRQ-------LDCSP 453
            :.:...|.:|:..::...||  ||..||           ||....|...:..|       |:...
Mouse   207 ELEKPMQSKPQSPVIQATAG--SPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGE 269

  Fly   454 IPRSQ----SG-ASPASISSS-----------TVSTSALASHPHVNLLHAAEPH----------Y 492
            .||.:    || |.|:..:.|           .|.|||:.        .|||.|          .
Mouse   270 APRERGSPVSGRAEPSRGTDSGAQEVVKDILEDVVTSAVK--------EAAEKHGLPEPDRALGA 326

  Fly   493 YNAQ--ALPQGAAYYTSYHGSPHDLSYASSADT--------SLNASWVNTSGHSPHTPYYSAAQI 547
            ...|  |:|.|....:..:|...|....||||.        .:.|.:.:.........:.|..::
Mouse   327 LECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKL 391

  Fly   548 YMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPS 612
            .|:|.|                          :.||: ||.....:.....||||...|...|
Mouse   392 SMKPLG--------------------------EGPPD-PKSHELRSKVVSLQLLLSVLQNAGP-- 427

  Fly   613 LLRTNGLCKTAENGSLTSVQSSGSDSSVTSA----------------------------ERNLNS 649
            :.|::.:..||....|....|....|||...                            |..||.
Mouse   428 VFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNI 492

  Fly   650 DLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQM------QAAVA 708
             |.:..|:..|.|.      ..|..:...||:...|.   :.|.....:.||.:      ..:..
Mouse   493 -LETSTSSFEHRWM------VIQTLTRICADAQCVVD---IYVNYDCDLNAANIFERLVNDLSKI 547

  Fly   709 AATAAG---GMPPADDHAI--------------------------SSHTSAAQYEQHEQQQHEQQ 744
            |...:|   ||.|..:.::                          :...:..|....:|:..:.:
Mouse   548 AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGK 612

  Fly   745 QLQAA--------------AAAAGVAQNYKMSETIRKRQYRV--GLNLFNKKPEKGITYLIRRGF 793
            .|..|              .....:..:.:..|.|::::..:  |:.||||||::||.:|..:|.
Mouse   613 GLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGM 677

  Fly   794 LENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFR 858
            |....:.:|:||...:.|....:||:||: ..:||..|:..:..:||...::...|||.|...||
Mouse   678 LGAAVEDIAQFLHQEERLDSTQVGEFLGD-STRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFR 741

  Fly   859 MPGEAQKIERLMEIFSQRYCECNADIVGR--LRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRV 921
            :|||||||:||||.|:.||.|||.   |:  ..|:||.:|||::||||.||||:|.:|  .:|..
Mouse   742 LPGEAQKIDRLMEKFAARYIECNQ---GQTLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTK 801

  Fly   922 EDFIKNLRGIDDCHDIDKDMLMGIYDRV--KSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRR 984
            |.:||..|||:|..|:.::.|..|||.:  |....|...:|.......:.::..:|      .||
Mouse   802 EQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVASEK------QRR 860

  Fly   985 LVCYCRLYEI 994
            |     ||.:
Mouse   861 L-----LYNV 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	79/193 (41%)
		PH_IQSEC	981..1108	CDD:270128	5/14 (36%)
Arfgef2	NP_001078964.1	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224		12/81 (15%)
		PLN03076	11..1718	CDD:215560	183/790 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..294		20/88 (23%)
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	515..535		5/22 (23%)