DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment siz and CYTH1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001351969.1	Gene:	CYTH1 / 9267	HGNCID:	9501	Length:	399	Species:	Homo sapiens

Alignment Length:	252	Identity:	96/252 - (38%)
Similarity:	149/252 - (59%)	Gaps:	18/252 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   720 DDHAISSHTSAAQYEQHEQQQHEQQQLQA--------AAAAAGVAQNYKMSE----TIRKRQYRV 772
            ::..:.|..:|.:.::.|..:..:|:|.|        .|..|...:|...:|    ..|.:|..:
Human     6 EEEDVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 70

  Fly   773 GLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAM 837
            |...||..|:|||.:||....|:||.:.:|:||...:||::..||:|||. :::||:.||..|..
Human    71 GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE-RDEFNIQVLHAFVE 134

  Fly   838 ELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAII 902
            ..:.:...:..|||:|...||:|||||||:|:||.|:||||:||.   |..:|:||.:||:||||
Human   135 LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNN---GVFQSTDTCYVLSFAII 196

  Fly   903 MLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSD 959
            ||||.||.||:|.  :..||.||...|||:|..|:.:::|..:|:.:|::.||...|
Human   197 MLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPED 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	83/187 (44%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128
CYTH1	NP_001351969.1	Sec7	64..246	CDD:396096	83/187 (44%)
CYTH1	NP_001351969.1	PH_GRP1-like	261..380	CDD:269954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910