DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and GBF1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006718110.1	Gene:	GBF1 / 8729	HGNCID:	4181	Length:	1893	Species:	Homo sapiens

Alignment Length:	961	Identity:	198/961 - (20%)
Similarity:	335/961 - (34%)	Gaps:	311/961 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 ASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRT--PPTRSLSMRERRQL 449
            :|:||...||..|..|:...:..:|...:..:|.:..|   .|||.|..  |.:..|.:.|:..|
Human   308 SSASSEAASAVVSPSTDSGLEFSSQTTSKEDLTDLEQP---GSPGYSTATEPGSSELGVPEQPDL 369

  Fly   450 --DCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGS- 511
              :.:.:.:||| ||..||.......::.|.|.....:|  :..|.|    |:|..:..|....
Human   370 QQEGTHVEKSQS-ASVESIPEVLEECTSPADHSDSASVH--DMDYVN----PRGVRFTQSSQKEG 427

  Fly   512 ----PHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGG--------STTPTPSCSG 564
                |:.|.........|      .|..:||..:.|...|:|    |        .:.|...|..
Human   428 TALVPYGLPCIRELFRFL------ISLTNPHDRHNSEVMIHM----GLHLLTVALESAPVAQCQT 482

  Fly   565 STG--------------SGSGGSGSGSSKKV------------------------------PPEV 585
            ..|              |....:...:|.:|                              .|::
Human   483 LLGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKM 547

  Fly   586 PKRTSSITAQQQTQL----------------------------LLLQRQTPPPPSLLRTNGLCKT 622
            |.....:..:...||                            .||.:...|....|.|..|...
Human   548 PYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEELTKLLSKNAFPVSGQLYTTHLLSL 612

  Fly   623 AENGSLTSVQSSGSD------SSVTSAERNLNS-------DLGSDRSNSPHTWKRGTALNSSQQF 674
              :..||.:.|:.:.      :|:|..|:...:       |...:.||:..|...|.|:..:...
Human   613 --DALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDI 675

  Fly   675 STHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQ 739
            .             |:.:.||                  |.:||  :|..|..:...:
Human   676 P-------------GLHLPGG------------------GRLPP--EHGKSGCSDLEE------- 700

  Fly   740 QHEQQQLQAAAAAAGVAQNY---------------KMSETIRKRQYRV-GLNLFNKKPEKGITYL 788
                      |..:|..:.:               ::.|...|::..: |...||:||:|||.:|
Human   701 ----------AVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFL 755

  Fly   789 IRRGFL----ENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVA 849
            ..:|.|    :||.  ||::|.....|.::||||::.:.:   |:.:|..|.......|.::|.|
Human   756 QEKGLLTIPMDNTE--VAQWLRENPRLDKKMIGEFVSDRK---NIDLLESFVSTFSFQGLRLDEA 815

  Fly   850 LRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLK 914
            ||.:...||:||||..|:||:|.|::|:..||.   ....:||..|.||:|:||||||.|..|::
Human   816 LRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNG---SPFANSDACFSLAYAVIMLNTDQHNHNVR 877

  Fly   915 PERR-MRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNL 978
            .:.. |.:|:|.|||:|::...|.::|:|..:|..:|::|.         ||..:.|.:.::..:
Human   878 KQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEI---------VMPEEQTGLVRENYV 933

  Fly   979 --ALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLC 1041
              .|.||...        |:       |:..|......||.:.|..:.....:::|.|..|  |.
Human   934 WNVLLHRGAT--------PE-------GIFLRVPTASYDLDLFTMTWGPTIAALSYVFDKS--LE 981

  Fly  1042 GTVVTLLDMPNYPFCIQLS-----QKVDGKILITFNARNEHDRCKFAEDLKESISEMDE------ 1095
            .|::... :..:..|..:|     ..|...::|:.        |||.....|||..:..
Human   982 ETIIQKA-ISGFRKCAMISAHYGLSDVFDNLIISL--------CKFTALSSESIENLPSVFGSNP 1037

  Fly  1096 ---------------------------MESL------------RIEAE----------LERQKSA 1111
                                       ||::            .||.|          |:|:::.
Human  1038 KAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETP 1102

  Fly  1112 RNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSAL 1162
            .||......:..|.:.         ..|.:.|..:.|::  .:|:.||.||
Human  1103 SNRGESTVLSFVSWLT---------LSGPEQSSVRGPST--ENQEAKRVAL 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	70/193 (36%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	29/186 (16%)
GBF1	XP_006718110.1	Sec7_N	434..579	CDD:289549	19/154 (12%)
GBF1	XP_006718110.1	Sec7	733..918	CDD:279680	70/192 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740