Protein Alignment siz and SYT1

DIOPT Version :9

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_015420.1
• Gene: SYT1 / 856210
• SGDID: S000006299
• Length: 1226
• Species: Saccharomyces cerevisiae
• Alignment Length: 936
• Identity: 170/936 - (18%)
• Similarity: 278/936 - (29%)
• Gaps: 349/936 - (37%)

  Fly   364 KAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQP------------ 416
            |...:|||    ....:|..:....|::..||..:..|..|..:.....::.|
Yeast    74 KKHSKLSR----IRRKMGRLDLNFRSANEKGSEDDEILVAQHLRNGQDPEEMPFKSENNIDSIEK 134

  Fly   417 -------RVTIMA------------GPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGAS 462
                   |||:.:            .|.....|.|.:.|.:..||...|:..:  |...:.....
Yeast   135 VPKPDGERVTLTSSGSDNVKRNSKHAPFIPVKPALEKFPSSNRLSRDYRKSQE--PTLFNGDRLV 197

  Fly   463 PASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNA 527
            |...:.|.:|||:....      ..|...|:|    |...|...|...|...:.:.|.....|:|
Yeast   198 PTLPTVSRISTSSSVGS------STAASRYFN----PSKRAVVASSSSSSSSIKFNSLHAIPLDA 252

  Fly   528 SWVNTSGHSPHTPYYSAA----QIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKR 588
                       ||....|    :|..|..|...:.|.........      :.::|..||..|..
Yeast   253 -----------TPQIELAKQQDEISKRRFGRRRSRTVDVFDYINK------NNTAKNKPPLSPSS 300

  Fly   589 TSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGS 653
            ......::.|..|:   |.|             ....|.|..     .|:::.|     |...|:
Yeast   301 FIRTIDEKNTNSLM---QDP-------------MGSRGPLLP-----DDANIIS-----NDTDGA 339

  Fly   654 DRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGG--------------VGVAGGAGVYAAQMQ 704
            :.|:..|           |..|...:.|...|.|.|              :|:..|:|..:....
Yeast   340 EASHPDH-----------QVLSRSRSQSTSFVQGKGGKRKSIEDEGYHNKLGLPHGSGPTSVYNN 393

  Fly   705 AAVAAATAAGGMPPADD--HAISSHTS------AAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKM 761
            .:.|.:|..|....:..  :|:||..:      ::..:||.||   |||||
Yeast   394 KSNANSTITGMSRRSSSIVNALSSFVNLRSSSLSSSRQQHLQQ---QQQLQ-------------- 441

  Fly   762 SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQ 826
                  ::..|.|......|....:...:...::..|.|             :.||..|....::
Yeast   442 ------QKLDVSLEDLPPVPAPEFSDSCKDFLIKLAPYG-------------KFIGIILTEKDDE 487

  Fly   827 F-----NMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRY--------- 877
            |     |..:.:||..:.|    .:|:||||...:..:|.|.|:|:||:..||..|
Yeast   488 FKKNCLNYLLTNCFEFKND----PLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSK 548

  Fly   878 ---CEC---NADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHD 936
               .||   ||         |.::.:||:::||:||...||.|  .:|...||:
Yeast   549 KKGIECPWSNA---------DQVYFIAFSLLMLHTDYFNPNNK--SKMTKHDFV----------- 591

  Fly   937 IDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKE 1001
                      |.|.:|::..|:                                  |||
Yeast   592 ----------DLVHNDKYSGGN----------------------------------EIP------ 606

  Fly  1002 RPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGK 1066
                                     ...:||.:.|        ||..:.|.:.:.:.....:|..
Yeast   607 -------------------------MAVLTYFYEN--------VTAKESPKFNYFLMSPMALDDS 638

  Fly  1067 IL----------ITFNARNEHDRCKFAEDLKESISEMDEMESLR-IEAELERQKSARNRAPGNAE 1120
            ||          ||.::.:.:...    |:.:..|.:.:..||. |...|....||
Yeast   639 ILDKDAFDTNFAITLSSNSMYSPI----DMIKRGSIIPKEASLSPIFYPLTNSISA--------- 690

  Fly  1121 NRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVG 1185
               ||:|......||.......:|.....:..||.:...:::|
Yeast   691 ---SGIAPSTAASCPPSTSGTINGANLGTANSNSNRPASNSIS---------------------- 730

  Fly  1186 SLDSGMSISFQSTTTSSASRENAAAI 1211
                    |:.|...||:|..||..:
Yeast   731 --------SYFSYNPSSSSSGNATLV 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	47/207 (23%)
		PH_IQSEC	981..1108	CDD:270128	20/137 (15%)
SYT1	NP_015420.1	COG5307	141..1221	CDD:227623	159/865 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000