DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and PSD2

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011535998.1	Gene:	PSD2 / 84249	HGNCID:	19092	Length:	791	Species:	Homo sapiens

Alignment Length:	530	Identity:	125/530 - (23%)
Similarity:	198/530 - (37%)	Gaps:	133/530 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 PKGGSTT----PTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPP 611
            |:.|..|    |.|.......:|....|..||...|....:.|.:.|          :..|..|.
Human    31 PEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADT----------EEPTKDPD 85

  Fly   612 --------SLLRTNGLC-----KTAENGSLTSVQSSGSDSSVTSAERNLNSD-----LGSDRSNS 658
                    .|..||||.     ...|:.:.:....:|..:...:|.|:|..|     ||.|....
Human    86 VAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAEDPQLGLDGPGE 150

  Fly   659 PH-------TWK--------RGTALNSSQQFS----THSADSA---------------------G 683
            |.       |::        |||..:|.....    |..:||.                     |
Human   151 PDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQQRARDSPEPG 215

  Fly   684 AVSG-------GGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISS--HTSAAQYEQHEQQ 739
            |..|       |.:|.|||.|...:.::.:::::.:...:......|:.:  |....|....::.
Human   216 AGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGDED 280

  Fly   740 QHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGV--- 801
            ..|:...:...:|:..:....:|::..:.....||...:..|            |.|..|||
Human   281 DDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADP------------LANGCQGVSEA 333

  Fly   802 ----ARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGE 862
                ||.|...:|..|..:...||. .|:|:..|...:....|.||..:|.|||.|...|.:.||
Human   334 AHRLARRLYHLEGFQRCDVARQLGK-NNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGE 397

  Fly   863 AQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKN 927
            .|:.||::..||:|||:||.|   ...|.|.|..|..|:::||||||..|:  .::|..:.||.|
Human   398 TQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GKKMSCQQFIAN 457

  Fly   928 LRGIDDCHDIDKDMLMGIYDRVKS---------------------DEFKPGSDHVTQVMKVQATI 971
            |..::|..|..||:|..:|:.:|:                     |:|..|:..||:::.
Human   458 LDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILD----- 517

  Fly   972 VGKKPNLALP 981
             |..|.|.:|
Human   518 -GGNPFLDVP 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	65/215 (30%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	1/1 (100%)
PSD2	XP_011535998.1	Sec7	317..484	CDD:238100	62/184 (34%)
		PH_EFA6	530..653	CDD:270107
		PH	550..645	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148860
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740