Protein Alignment siz and iqsec2b

DIOPT Version :9

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_005167294.1
• Gene: iqsec2b / 797187
• ZFINID: ZDB-GENE-081105-73
• Length: 1581
• Species: Danio rerio
• Alignment Length: 1282
• Identity: 404/1282 - (31%)
• Similarity: 575/1282 - (44%)
• Gaps: 328/1282 - (25%)

  Fly    78 VDELLRENNALHAKIKELSLERDRLLCEVSNLRLELDMSELKRLPVDL-DDNFPQKSLERSGSTQ 141
            |:.||..||.:..:.|.|..:|.|:      ..||..:..:.:...|| .|..|.::     |||
Zfish    12 VEYLLELNNIIENQAKLLDTQRKRI------EELETQLDRVNQENQDLRHDRTPTEN-----STQ 65

  Fly   142 ---YELAGAQ-QPGSANASTCTDSGSVGGYVYLQNHYAPGAHSSSAAINYPAQQHPQMVYQIQQY 202
               |..:... ||.|                 |.||.|.|.|.:|:. |.|:.
Zfish    66 IHNYNQSSKPIQPTS-----------------LPNHNAGGVHQNSSG-NVPSS------------ 100

  Fly   203 PTCHQQQQQQHLQQQQHLHQTGAGHYMQVTATGGGQYHHHHMLHGHGHHAHHHGGAVVIAGSG-- 265
                                         |..|..:..|..:..|..     .|.|.|....|
Zfish   101 -----------------------------TVPGPARRTHTRLTRGLS-----CGSAPVDKDRGRL 131

  Fly   266 -VGTGLGSGATSVIMQHQQQQQ----------QQQNMHKKNSIRNGGDV---------------- 303
             .....|:..||.:.:|:::.|          ..::.:..:|.|.|.:.
Zfish   132 DRNDSSGTNNTSTLWKHEEETQSSAARPFSESSSKSPYVHSSDRYGDNSCGPPGPRVPFVPPPSP 196

  Fly   304 -----LKRTRAQSA---------------------YELSQDLLEKQIELLERKYGG-VRARNAAV 341
                 .:|||.|.|                     ||||.||.:|::|:||:|||| ..:|.||.
Zfish   197 ASLAWAQRTRNQPASLALRKQEEEENKRCKALSDSYELSTDLQDKKVEMLEKKYGGYFVSRRAAR 261

  Fly   342 TIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQ 406
            |||.|||.|.|.|.|..:.:.| :|.|::||::::...|                        |.
Zfish   262 TIQTAFRQYRMNKNFERLRSSA-SESRMTRRIILSNMRL------------------------QY 301

  Fly   407 QQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMR-ERRQLD-------------------C 451
            ....:..|.|..|..:...|...|. |.|..|...|.| |..||:                   |
Zfish   302 SFDDRHPQPPNPTHYSHSPGMGPPH-SPTSTTEPSSPRPEYTQLEDTFSKQVKSLADSIDDALTC 365

  Fly   452 SP-IPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDL 515
            .| ...||.|....|...........:|:.|.              :|.:|.|          |.
Zfish   366 RPRRDDSQEGIGDVSGVVDDFGECIWSSNSHA--------------SLRRGLA----------DR 406

  Fly   516 SYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTP-----TPSCS-----GSTGSGS 570
            ....:...|::.....||        ||...:|| ..|..::|     .||.:     |..|||.
Zfish   407 DRGGTGGLSMHEDSTATS--------YSDVTLYM-DDGLPSSPLSLDRAPSSTDTEFWGGVGSGV 462

  Fly   571 GG-------SGSGSSKKVPPEVPKRTSSITAQQQTQL----LLLQRQTPPPPSLLRTNGLCKTAE 624
            ||       .|.|||..      :|::..|..:..:|    |.|....||..|.:   .:...::
Zfish   463 GGREDSRDTEGGGSSNS------RRSTPCTECRDYRLRGGHLPLLTIEPPSDSSV---DMSDRSD 518

  Fly   625 NGSLTS----VQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTH-------- 677
            .|||:.    .|.|...|...:.:.|.|:     ||.| .|..:|....:|:...:|
Zfish   519 RGSLSRQLVYEQDSAGGSPQGTLKHNPNA-----RSQS-STTAQGQTRPASRSIPSHIPHHMAHH 577

  Fly   678 -----------SADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPP----------ADD 721
                       ..|:..:.|.            ..|......:::::..:||          .|:
Zfish   578 HHHHHHHHHHQYPDTPSSSSS------------PQQPPTTPLSSSSSAPLPPGGLEQQCCSDGDN 630

  Fly   722 HAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKM------------SETIRKRQYRVGL 774
            .:::|.|::.:..........:..|:......| .|.|:.            ::.:::||||:||
Zfish   631 DSLNSTTNSNETINCSSGSSSRDSLREPLPPLG-KQTYQRESRHNWDSPAFNNDVVQRRQYRIGL 694

  Fly   775 NLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMEL 839
            |||||||||||.|||.:||:.:||.|:|||::.|||||||||||:|||.|.|||..||.|...|:
Zfish   695 NLFNKKPEKGIQYLIEKGFVSDTPVGIARFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVVDEM 759

  Fly   840 DLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIML 904
            |.||..:|.|||||||..::.|||||:|||:|.||||||.||..:|.:.::.||||:||||||:|
Zfish   760 DFSGMDLDDALRKFQAQIKVQGEAQKVERLIEAFSQRYCVCNPALVRQFQNPDTIFILAFAIILL 824

  Fly   905 NTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQA 969
            |||:::||:|.||:|:::||||||||:|:..:|.:|:|:|||.|::..|.:...|||:||..|:.
Zfish   825 NTDMYSPNIKAERKMKLDDFIKNLRGVDNGQEIPRDLLVGIYQRIQKWELRTNDDHVSQVQAVER 889

  Fly   970 TIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTF 1034
            .||||||.|:||||||||.|:|:|:||.|:.:|.|||||||||||||||:||||.||||||||:|
Zfish   890 VIVGKKPVLSLPHRRLVCCCQLHEVPDPNRPQRSGVHQREVFLFNDLLVVTKIFQKKKTSVTYSF 954

  Fly  1035 RNSFPLCGTVVTLLDMPNYPFCIQLSQKVDG---KILITFNARNEHDRCKFAEDLKESISEMDEM 1096
            |.||||....|.:.....||..::|:..:.|   |:||.|.|.::.||.:|..||:|||:|:.||
Zfish   955 RQSFPLVEMQVHMFQNSYYPHGVRLTSAIPGGERKVLIVFTAPSQQDRTRFVSDLRESIAEVQEM 1019

  Fly  1097 ESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNS----QQL 1157
            |..|:|:|||:||.....:.........||..|        :....:|.....|.|::    :.|
Zfish  1020 EKYRVESELEKQKGVMRPSLLTNSIMAGGVGGV--------KNEVVNGTMGRPSLDDNYSPGEGL 1076

  Fly  1158 KRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQSTTTSSAS 1204
            ||:|||:||.|:.|   :.|..||.|||||||.|.:|......|:||
Zfish  1077 KRTALSSSLRDLSE---SGKRGRRNSVGSLDSTMEVSLSEAEQSTAS 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	115/187 (61%)
		PH_IQSEC	981..1108	CDD:270128	74/129 (57%)
iqsec2b	XP_005167294.1	Sec7	686..871	CDD:279680	115/184 (63%)
		IQ_SEC7_PH	899..1026	CDD:293062	71/126 (56%)
		PH	926..1014	CDD:278594	48/87 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582809
Domainoid	1	1.000	265	1.000	Domainoid score	I1852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1190
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360558at33208
OrthoFinder	1	1.000	-	-		FOG0002052
OrthoInspector	1	1.000	-	-		otm25632
orthoMCL	1	0.900	-	-		OOG6_104559
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4991
SonicParanoid	1	1.000	-	-		X920
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.020