DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Cyth4

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_082471.2	Gene:	Cyth4 / 72318	MGIID:	2441702	Length:	393	Species:	Mus musculus

Alignment Length:	414	Identity:	122/414 - (29%)
Similarity:	188/414 - (45%)	Gaps:	88/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   727 HTSAAQY---EQHEQQQ---HEQQQL--------QAAAAAAGV-----AQNYKMSETIRKRQYRV 772
            ||..|:.   |..|.||   |.:|.|        :.|...|.:     .:..:|::  ::::..:
Mouse     5 HTDPAELSSGEAKELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFESTEESRMAQ--KEKEMCI 67

  Fly   773 GLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAM 837
            |...||..|.|||.|||....|.:..|.:|:||....||::..||.|||. ::..|:.||..|..
Mouse    68 GRKKFNMDPNKGIQYLIEHKLLTSDVQDIAQFLYKGDGLNKTAIGTYLGE-KDPINLQVLQAFVD 131

  Fly   838 ELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAII 902
            ..:.:...:..|||:|...||:|||||||:|:||.|:.|||.||.   |..||:||.:||:|::|
Mouse   132 CHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNP---GVFRSTDTCYVLSFSVI 193

  Fly   903 MLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFK----PGSDHVTQ 963
            ||||.||.||::.  |...|.|:...|||:...|:.::.|..::|.:||:.|.    .|.|
Mouse   194 MLNTGLHNPNVRD--RPPFERFVTMNRGINSGSDLPEEQLRNLFDSIKSEPFSIPEDDGGD---- 252

  Fly   964 VMKVQATIVGKKPNLALPHRRLVCYCRLYEIPD-----VNKKERPGVHQREVFLFNDLLVITKIF 1023
                            |.|        .:..||     :....|....:|..|:..|..:....|
Mouse   253 ----------------LTH--------TFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEF 293

  Fly  1024 SKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQL------SQKV-------DGKIL------I 1069
            :..|..     |...||....|..::.|..|||::|      .||:       |||::      .
Mouse   294 TTDKEP-----RGIIPLENLSVQKVEDPKKPFCLELYNPSCRGQKIKACKTDGDGKVVEGKHESY 353

  Fly  1070 TFNARNEHDRCKFAEDLKESISEM 1093
            ..:|.|..:|.::.|.::.||:.:
Mouse   354 RISAANAEERDQWIEAIRASITRV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	76/187 (41%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	29/137 (21%)
Cyth4	NP_082471.2	Sec7	61..243	CDD:279680	76/187 (41%)
		PH_GRP1-like	258..376	CDD:269954	28/122 (23%)
		PH	262..374	CDD:278594	24/116 (21%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275		1/6 (17%)
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740