Protein Alignment siz and Iqsec1

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_038964676.1
• Gene: Iqsec1 / 686590
• RGDID: 1596313
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 1346
• Identity: 424/1346 - (31%)
• Similarity: 587/1346 - (43%)
• Gaps: 352/1346 - (26%)

  Fly    47 AGGVAPPGPVSLPLPLSINMPHHHVHAMPYNVDELLRENNALHAKIKELSLERDRLLCEVSNLRL 111
            |....|||..:                      |.|:|...:.|..:||..:|.|.:.|     |
  Rat     2 ASAAEPPGTAA----------------------EYLQELTRIVAAQQELLAQRRRRIEE-----L 39

  Fly   112 ELDMSELKRLPVDLDDNFPQKSLERSGSTQYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYAP 176
            |..::.|.|....|        |||........|....||.:         .:|....|.:....
  Rat    40 ERQVARLSRENAGL--------LERHRRHLAACARRPDPGPS---------PLGAIPELSSRRDK 87

  Fly   177 GAHSSSAAINYPAQQHPQMVYQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHYMQVTATGGGQYHH 241
            ....||.:|....:....:            ...:..::.:....:||      .:......||.
  Rat    88 SEEESSRSIRSSLETGSSL------------STDRYSVEGEAPSSETG------TSLDSPSAYHQ 134

  Fly   242 HHMLHGHG----HHAHHHGGAV-VIAGSGVGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGG 301
            ..::.|..    |:.|...||. :.||.|               .||:.::.:..|..:.:|...
  Rat   135 GPLVPGSSLSPDHYEHTSVGAYGLYAGPG---------------PQQRTRRPRLQHSTSVLRKQA 184

  Fly   302 --DVLKRTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAM 362
              :.:||:|:.| :||||.||.:||:|:||||||| :..|:||.|||.|||.|.|.|.|..:.:
  Rat   185 EEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRS- 248

  Fly   363 AKAEKRLSRRMVVTASSLGLAEEGASS-SSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAG 426
            :.:|.|:|||:|::...:..:.||... .|:|....:..:|....|..|         ::....|
  Rat   249 SMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGA---------LVPSECG 304

  Fly   427 AAS-PGLSRTPPT-------------------------------RSLSMRE-------------- 445
            ..| |.|....|:                               |||...|
  Rat   305 DLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEP 369

  Fly   446 --------RRQLD------------------CSPIPRSQSGASPASISSSTVSTSALASHPHVNL 484
                    .|:||                  ..|:|.||:|..|:|..|.....|..|:..:..|
  Rat   370 KPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWAL 434

  Fly   485 LHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSP----HTPYYSAA 545
            .|..:.           |...||...:|.    ....:..|...      |.|    ..|..|:.
  Rat   435 AHKEDK-----------ADTDTSCRSTPS----LERPEPRLRVE------HLPLLTIEPPSDSSV 478

  Fly   546 QIYMRPKGGS----TTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQ 606
            ::..|....|    :....|..|..||...|...|..|.:|.|.|:                  .
  Rat   479 ELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPE------------------L 525

  Fly   607 TPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSS 671
            .|.||..|.::    .|.|||......|.||          .||..:|..||  |......:|.|
  Rat   526 RPRPPRPLESH----LAINGSANRQSKSESD----------YSDGDNDSINS--TSNSNDTINCS 574

  Fly   672 QQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQH 736
            .:                                                  .||..|..:....
  Rat   575 SE--------------------------------------------------SSSRDSLREQTLS 589

  Fly   737 EQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGV 801
            :|..|::.:....:.|..       ::.||||.||:|||||||||||||.|||.|||:.:||.||
  Rat   590 KQTYHKETRNSWDSPAFS-------NDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGV 647

  Fly   802 ARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKI 866
            |.||:.|||||||||||:|||.|.|||..||.|...|:|.|..::|.|||||||:.|:.|||||:
  Rat   648 AHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKV 712

  Fly   867 ERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGI 931
            |||:|.||||||.||..:|.:.|:.||||:||||||:||||:::||:||||:|::|||:|||||:
  Rat   713 ERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGV 777

  Fly   932 DDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKP----------NLALPHRRLV 986
            ||..||.::.|:|||:|::..|.|...|||:||.||:..||||||          .|:|||||||
  Rat   778 DDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLV 842

  Fly   987 CYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMP 1051
            |||||:|:||.||.::.|:||||:||||||||:||||.|||.||||:||.||.|.|..|.|.:..
  Rat   843 CYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQ 907

  Fly  1052 NYPFCIQLSQKVDG---KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARN 1113
            .||..|:|:..|.|   |:||.|||.|..||.||.:||:||::|:.|||..|||:|||:||
  Rat   908 YYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQK---- 968

  Fly  1114 RAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNS----QQLKRSALSNSLLDMHEQFG 1174
                       ||....:..|...:....:|..:....|:|    :.|||||||:||.|:.|.
  Rat   969 -----------GVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA-- 1020

  Fly  1175 NEKPQRRGSVGSLDSGMSISFQST----TTSSASRE----------NAAAIAAAANAAAAAKMRF 1225
             .|..||.|.|||:|.:..|..|:    ..::::||          |::::..:...:...|...
  Rat  1021 -GKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPPQPVPNSSSLLGSLFGSRRGKPPP 1084

  Fly  1226 NM-PPTAAIATPSNVYAAPGMQ---------AYTHANFVQQSQAAY 1261
            .. ||:|....|.:.: .||..         .|.||   ||:...|
  Rat  1085 QAHPPSAPPPAPPHAH-HPGPSEGPLHGHHAQYCHA---QQNPPPY 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	121/187 (65%)
		PH_IQSEC	981..1108	CDD:270128	79/129 (61%)
Iqsec1	XP_038964676.1	Sec7	612..800	CDD:460178	121/187 (65%)
		IQ_SEC7_PH	832..961	CDD:465120	76/128 (59%)