DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and gbf1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_009305378.1	Gene:	gbf1 / 566350	ZFINID:	ZDB-GENE-081107-54	Length:	1862	Species:	Danio rerio

Alignment Length:	1079	Identity:	239/1079 - (22%)
Similarity:	384/1079 - (35%)	Gaps:	292/1079 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 QSAYELSQD----LLEKQIELLERKYGGVRARNAAV-TIQRAFRHYMMVKKFASI---TAMAKAE 366
            :|..|:.|.    ..|.::..|.||    .|.:..| .:|..|......|:.|..   |.|.||.
Zfish   155 ESVCEIMQSCFRICFEMRLSELLRK----SAEHTLVDMVQLLFSRLPQFKEEAKSYVGTNMKKAY 215

  Fly   367 KRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPG 431
            ..|.:...|   .|.:...|.|.||.:             ::|.:..:.|| .::..|:|...|.
Zfish   216 NILWKNKRV---QLKMRAGGMSESSKW-------------KKQKRSPRPPR-HMVRSPSGQMDPA 263

  Fly   432 LSRTPPTRSLS----MRERRQLDCSPIPRSQSGASPASISSSTVST------------------- 473
            .|.| .|.:||    ..|:.....|..|.|.|.||  ||||.|..:
Zfish   264 QSST-LTNNLSGGVPFIEQHSGGSSTFPGSDSAAS--SISSPTTDSGLDTGSKTTSKEDLTDLDQ 325

  Fly   474 -SALASHPHVNLLHAAEPHYYNAQALPQGA--AYYTSYHGSPHDLSYASSADTSLNASWVNTSGH 535
             |:.|:.|   :..:|||....:|:..:|.  |...|....|..|.     |..|.|.  .:...
Zfish   326 NSSTATTP---ITPSAEPGRLESQSEGRGVERAQSASVESIPEVLE-----DRDLLAD--QSDSA 380

  Fly   536 SPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVP-------------- 586
            |.|.      ..|:.|:|...|.:....|:.             .:|..:|
Zfish   381 SVHD------MDYVNPRGVRFTQSTQKEGAA-------------LIPYGLPCLRELFRFLISLTN 426

  Fly   587 ---KRTSSITAQQQTQLL---LLQRQTPPPPSLLR--TNGLCK---------------------- 621
               :..|.:......|||   |......|..|||.  .:.||:
Zfish   427 PHDRHNSDVMMHMGLQLLNVALEAAHIAPYQSLLGLVKDELCRHLIQLLGVDRMNLYTASIRVCF 491

  Fly   622 -------------------------TAENGSL----------TSVQSSGSDSSVTSAERNLN--- 648
                                     |:||..:          ..||.....|.||....|.:
Zfish   492 LLFESMREHLKFQLEMYLKKLMDIITSENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDF 556

  Fly   649 --SDLGSDRS-----------------------------NSPHTWKRGTALNSSQQFSTHSADSA 682
              |:|..|.:                             :|.....:...|||:.|.....:.:.
Zfish   557 YCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLEALLTVIDSTEAHCQAKVLNSATQQEQSESTTV 621

  Fly   683 GAVSGGGV---GVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQ 744
            |..|...:   ....|....::..|.:|.:.|.| ..||...|.::......:.:|.|....|::
Zfish   622 GDSSVSTITDSPAETGKPHPSSNGQNSVVSETRA-SCPPTSGHLMAEKMRLGRQDQEETDTGEKK 685

  Fly   745 -QLQAAAAAAGVAQNYKMSETIRKRQYRV-GLNLFNKKPEKGITYLIRRGFLENTPQG--VARFL 805
             ..:....::.:..:.::.|...|::..: |...||:||:|||..|..:|.|.:....  ||::|
Zfish   686 ISKKPHRFSSYLPDSQELLEIKNKKKLLITGTEQFNQKPKKGIQTLQEKGLLSSPMDNNEVAQWL 750

  Fly   806 ITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLM 870
            .....|.::||||::.:.:   |..:|..|.......|.::|.|||.:...||:||||..|.||:
Zfish   751 RENPRLDKKMIGEFISDRR---NTDLLDSFVNTFTFQGLRIDEALRLYLEAFRLPGEAPVIHRLL 812

  Fly   871 EIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPER-RMRVEDFIKNLRGIDDC 934
            |.|:..:.:.|.:   ..:::|..|.||:|:||||||.|..|::.:. .|.:|.|.|||:|::..
Zfish   813 ETFTDNWHKVNGN---PFQTNDAGFALAYAVIMLNTDQHNHNVRKQNIPMTLEQFKKNLKGVNGG 874

  Fly   935 HDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNL--ALPHRRLVCYCRLYEIPDV 997
            :|.|:|||..||:.:|::|.         ||..:.|.:.|:..:  .|.||..........:||
Zfish   875 NDFDQDMLEDIYNAIKNEEI---------VMPDEQTGLVKENYVWSVLLHRGASAEGMFLHVPD- 929

  Fly   998 NKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLS-- 1060
                  |.:.|::|        :..:.....:::|.|..|  |..|::... :..:..|..:|
Zfish   930 ------GSYDRDLF--------SMTWGPTIAALSYVFDKS--LDDTIIEKA-IAGFRKCAMISAH 977

  Fly  1061 ---QKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENR 1122
               ..|...::|:.        |||.....||:..:..:                     ...||
Zfish   978 YGFSDVFDNLIISL--------CKFTTLSSESVENLPTV---------------------FGSNR 1013

  Fly  1123 DSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSAL-------SNSLLDMHEQFG---NEK 1177
            .:.||...|....::.| ....:...|..|:..||.|:.|       ....||.:|:..   .|.
Zfish  1014 KAQVAAKTVFSLAHRHG-DILRDGWKNIMDSMLQLFRAELLPKTMVEVEDFLDPNEKISLQREET 1077

  Fly  1178 PQRRG--SVGSLDSGMSISFQSTTTSSASRENAAAIAAA 1214
            |..||  :|.|..|.:::|.|| .....|.||..|..||
Zfish  1078 PSNRGESAVLSFVSWLTLSEQS-GLRGPSTENQEAKQAA 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	68/191 (36%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	21/131 (16%)
gbf1	XP_009305378.1	Sec7_N	410..555	CDD:289549	21/144 (15%)
		COG5307	493..>1170	CDD:227623	157/688 (23%)
		Sec7	709..894	CDD:279680	68/190 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740