DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and LOC560461

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_009302231.1	Gene:	LOC560461 / 560461	-ID:	-	Length:	1639	Species:	Danio rerio

Alignment Length:	1315	Identity:	413/1315 - (31%)
Similarity:	564/1315 - (42%)	Gaps:	382/1315 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VDELLRENNALHA----------KIKELSLERDRLLCEVSNLRLELDMSELKRLPVDLDDNFPQK 132
            |:.||..||.:.:          :|:||.::.|||..|..:|||:       |.|....   |..
Zfish    15 VEYLLELNNIIESQQKLLETQRRRIEELEVQLDRLSQENKDLRLD-------RQPCPPP---PPP 69

  Fly   133 SLERSGSTQYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYAPGAHSSS-AAINYPAQQHPQMV 196
            .:..:           .|.:::|:|.|            |.|....|:|. ..|..||...|...
Zfish    70 PIHPA-----------PPPTSHAATST------------NAYTNQIHNSGPIPIPIPAPAPPPPP 111

  Fly   197 YQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHY-------------MQVTATGG-------GQYHH 241
            ..:.  |...:.....|.:..|.|   .||..             :..|:.|.       |...:
Zfish   112 PPVP--PRDRRIIANTHTRLGQSL---SAGSISTDREGERKRERDVATTSLGSTLPRQPEGDSFN 171

  Fly   242 HHMLHGHGH-------------------HAHHHGGAVVIAG-SGVGTGLGSGATSVIMQHQQQQQ 286
            ...:.|...                   ::..:|....|.| .|...|..|.|:....|..:.|.
Zfish   172 KDSVEGDPQCPDTTSFSDSTCSQGPYLGNSERYGNIRNIPGPQGPPVGTASPASLAWAQRSRHQP 236

  Fly   287 QQQNMHKKNSIRNGGDVLKRTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRH 349
            ....:.|:..     :..||.:|.| :||||.||.:|::|:||||||| ..:|.||.|||.|||.
Zfish   237 ASLALRKQEE-----EESKRCKALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQ 296

  Fly   350 YMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQ 414
            |.|.|.|..:.:.| :|.|::||:::           ::..|.| |..|.|   .|.|.|..|||
Zfish   297 YRMNKNFQRLRSSA-SESRMTRRIIL-----------SNMRSQY-SFDERQ---PQVQPQTPQQQ 345

  Fly   415 QPRVTI-----MAGPAGAASPGLSRTPPTRSLSMRERRQ--------------------LDC-SP 453
            |.|.|.     .||..|:.:.......|....|.||...                    |.| |.
Zfish   346 QGRYTSHHTSGTAGQTGSTNTQQETDSPAHCPSDREEYSHADDAFNKQVTSLADSMDDTLTCQSG 410

  Fly   454 IPRSQSGASPASISS--------STVSTS---ALASHPHVNLLHA-------AEPHYYNAQALPQ 500
            ...||.|...|...|        |...||   .:.....:.::|.       ::...|....:|
Zfish   411 RGDSQDGGEGAREESVDFGECVWSNKPTSRRGVVGEQERLGVMHEDSTATSYSDVTLYMDDGMP- 474

  Fly   501 GAAYYTSYHGSPHDLS-YASSADTSLNASWVNTSG-----HSPHTPYYSAAQIYMRPKGGST--- 556
                     .||..:. ..||.||..   |..:||     .|..|           ..||||
Zfish   475 ---------CSPLSIERVPSSTDTEY---WGVSSGVGGREDSRDT-----------EGGGSTNSR 516

  Fly   557 --TPTPSC-------------------------SGSTGSGS-------------GGSGSGSSKKV 581
              ||...|                         |..:..||             |||..|:.|..
Zfish   517 RSTPCTECRDFRLRGSHLPVLTIEPPSDSSVDMSDRSDRGSLSRQLLYEQEPTAGGSPQGTLKHN 581

  Fly   582 PPEVPKRTSSITAQQQTQ------------------------------------LLLLQRQTPPP 610
            |  .|:..:...||.||:                                    |..:....|.|
Zfish   582 P--APRMPNPCAAQGQTRPTGRPIPSPLPTHLPHHAMMHHHHHPHLHHPLHHHPLPHMHHPYPDP 644

  Fly   611 PSLLRTNGLCKTAENGSLTSVQSSGSD---------SSVTSAERNLNSDLGSDRSNS-----PHT 661
            .|...|........:.|...:.:||.:         :|.|::...:|...||...:|     |..
Zfish   645 TSPSPTQPPLTPLSSSSSAPLPASGMEQSDGDNDSLNSTTNSNETINCSSGSSSRDSLREPLPPL 709

  Fly   662 WKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISS 726
            .|:     :.|:.|.||.||                                    ||.:
Zfish   710 GKQ-----TYQRESRHSWDS------------------------------------PAFN----- 728

  Fly   727 HTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRR 791
                                               ::.:::|.||:|||||||||||||.|||.|
Zfish   729 -----------------------------------NDVVQRRHYRIGLNLFNKKPEKGIQYLIER 758

  Fly   792 GFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAY 856
            ||:.:||.|:|||::.|||||||||||:|||.|.|||..||.|...|:|.||..:|.|||||||.
Zfish   759 GFVSDTPVGIARFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVLDEMDFSGMDLDDALRKFQAQ 823

  Fly   857 FRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRV 921
            .::.|||||:|||:|.||||||.||..:|.:.::.||||:||||||:||||:::||:|.||:|::
Zfish   824 IKVQGEAQKVERLVEAFSQRYCVCNPALVRQFQNPDTIFILAFAIILLNTDMYSPNVKAERKMKL 888

  Fly   922 EDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLV 986
            |||||||||:|:..||.:|:|:|||.|::..|.:...|||:||..|:..||||||.|:|||||||
Zfish   889 EDFIKNLRGVDNGQDIPRDLLVGIYQRIQKWELRTNDDHVSQVQAVERVIVGKKPVLSLPHRRLV 953

  Fly   987 CYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMP 1051
            |.|:|||:||.|:.:|.|||||||||||||||:||||.||||||||:||.||||....|.:....
Zfish   954 CCCQLYEVPDPNRPQRSGVHQREVFLFNDLLVVTKIFQKKKTSVTYSFRQSFPLVEMQVHMFQNS 1018

  Fly  1052 NYPFCIQLSQKVDG---KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARN 1113
            .|...|:|:..:.|   |:||.|||.::.||.:|..||:|||:|:.:||..|:|:|||:||....
Zfish  1019 YYAHGIRLTSAMPGAERKVLIVFNAPSQQDRTRFTSDLRESIAEVQDMEKYRVESELEKQKGVMR 1083

  Fly  1114 RAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNS----QQLKRSALSNSLLDMHEQFG 1174
              ||......|.|..::.        ...:|.....|.|::    :.|||:|||:||.|:.:
Zfish  1084 --PGLLSGEVSSVGGMKT--------EAVNGTLGRPSLDDTYAAGEGLKRTALSSSLRDLSD--- 1135

  Fly  1175 NEKPQRRGSVGSLDS 1189
            ..|..||.|||||||
Zfish  1136 TGKRGRRNSVGSLDS 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	117/187 (63%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	75/129 (58%)
LOC560461	XP_009302231.1	Sec7	733..918	CDD:279680	117/184 (64%)
		IQ_SEC7_PH	946..1073	CDD:293062	72/126 (57%)
		Sox_C_TAD	1323..>1414	CDD:288887
		SelP_N	<1499..1557	CDD:282453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582810
Domainoid	1	1.000	265	1.000	Domainoid score	I1852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1190
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360558at33208
OrthoFinder	1	1.000	-	-		FOG0002052
OrthoInspector	1	1.000	-	-		otm25632
orthoMCL	1	0.900	-	-		OOG6_104559
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X920
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.990