Protein Alignment siz and iqsec2a

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_073766410.1
• Gene: iqsec2a / 560461
• ZFINID: ZDB-GENE-170302-3
• Length: 1639
• Species: Danio rerio
• Alignment Length: 1315
• Identity: 413/1315 - (31%)
• Similarity: 564/1315 - (42%)
• Gaps: 382/1315 - (29%)

  Fly    78 VDELLRENNALHA----------KIKELSLERDRLLCEVSNLRLELDMSELKRLPVDLDDNFPQK 132
            |:.||..||.:.:          :|:||.::.|||..|..:|||:       |.|....   |..
Zfish    15 VEYLLELNNIIESQQKLLETQRRRIEELEVQLDRLSQENKDLRLD-------RQPCPPP---PPP 69

  Fly   133 SLERSGSTQYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYAPGAHSSS-AAINYPAQQHPQMV 196
            .:..:           .|.:::|:|.|            |.|....|:|. ..|..||...|...
Zfish    70 PIHPA-----------PPPTSHAATST------------NAYTNQIHNSGPIPIPIPAPAPPPPP 111

  Fly   197 YQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHY-------------MQVTATGG-------GQYHH 241
            ..:.  |...:.....|.:..|.|   .||..             :..|:.|.       |...:
Zfish   112 PPVP--PRDRRIIANTHTRLGQSL---SAGSISTDREGERKRERDVATTSLGSTLPRQPEGDSFN 171

  Fly   242 HHMLHGHGH-------------------HAHHHGGAVVIAG-SGVGTGLGSGATSVIMQHQQQQQ 286
            ...:.|...                   ::..:|....|.| .|...|..|.|:....|..:.|.
Zfish   172 KDSVEGDPQCPDTTSFSDSTCSQGPYLGNSDRYGNIRNIPGPQGPPVGTASPASLAWAQRSRHQP 236

  Fly   287 QQQNMHKKNSIRNGGDVLKRTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRH 349
            ....:.|:..     :..||.:|.| :||||.||.:|::|:||||||| ..:|.||.|||.|||.
Zfish   237 ASLALRKQEE-----EESKRCKALSDSYELSTDLQDKKVEMLERKYGGYFLSRRAARTIQTAFRQ 296

  Fly   350 YMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQ 414
            |.|.|.|..:.:.| :|.|::||:::           ::..|.| |..|.|   .|.|.|..|||
Zfish   297 YRMNKNFQRLRSSA-SESRMTRRIIL-----------SNMRSQY-SFDERQ---PQVQPQTPQQQ 345

  Fly   415 QPRVTI-----MAGPAGAASPGLSRTPPTRSLSMRERRQ--------------------LDC-SP 453
            |.|.|.     .||..|:.:.......|....|.||...                    |.| |.
Zfish   346 QGRYTSHHTSGTAGQTGSTNTQQETDSPAHCPSDREEYSHADDAFNKQVTSLADSMDDTLTCQSG 410

  Fly   454 IPRSQSGASPASISS--------STVSTS---ALASHPHVNLLHA-------AEPHYYNAQALPQ 500
            ...||.|...|...|        |...||   .:.....:.::|.       ::...|....:|
Zfish   411 RGDSQDGGEGAREESVDFGECVWSNKPTSRRGVVGEQERLGVMHEDSTATSYSDVTLYMDDGMP- 474

  Fly   501 GAAYYTSYHGSPHDLS-YASSADTSLNASWVNTSG-----HSPHTPYYSAAQIYMRPKGGST--- 556
                     .||..:. ..||.||..   |..:||     .|..|           ..||||
Zfish   475 ---------CSPLSIERVPSSTDTEY---WGVSSGVGGREDSRDT-----------EGGGSTNSR 516

  Fly   557 --TPTPSC-------------------------SGSTGSGS-------------GGSGSGSSKKV 581
              ||...|                         |..:..||             |||..|:.|..
Zfish   517 RSTPCTECRDFRLRGSHLPVLTIEPPSDSSVDMSDRSDRGSLSRQLLYEQEPTAGGSPQGTLKHN 581

  Fly   582 PPEVPKRTSSITAQQQTQ------------------------------------LLLLQRQTPPP 610
            |  .|:..:...||.||:                                    |..:....|.|
Zfish   582 P--APRMPNPCAAQGQTRPTGRPIPSPLPTHLPHHAMMHHHHHPHLHHPLHHHPLPHMHHPYPDP 644

  Fly   611 PSLLRTNGLCKTAENGSLTSVQSSGSD---------SSVTSAERNLNSDLGSDRSNS-----PHT 661
            .|...|........:.|...:.:||.:         :|.|::...:|...||...:|     |..
Zfish   645 TSPSPTQPPLTPLSSSSSAPLPASGMEQSDGDNDSLNSTTNSNETINCSSGSSSRDSLREPLPPL 709

  Fly   662 WKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISS 726
            .|:     :.|:.|.||.||                                    ||.:
Zfish   710 GKQ-----TYQRESRHSWDS------------------------------------PAFN----- 728

  Fly   727 HTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRR 791
                                               ::.:::|.||:|||||||||||||.|||.|
Zfish   729 -----------------------------------NDVVQRRHYRIGLNLFNKKPEKGIQYLIER 758

  Fly   792 GFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAY 856
            ||:.:||.|:|||::.|||||||||||:|||.|.|||..||.|...|:|.||..:|.|||||||.
Zfish   759 GFVSDTPVGIARFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVLDEMDFSGMDLDDALRKFQAQ 823

  Fly   857 FRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRV 921
            .::.|||||:|||:|.||||||.||..:|.:.::.||||:||||||:||||:::||:|.||:|::
Zfish   824 IKVQGEAQKVERLVEAFSQRYCVCNPALVRQFQNPDTIFILAFAIILLNTDMYSPNVKAERKMKL 888

  Fly   922 EDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLV 986
            |||||||||:|:..||.:|:|:|||.|::..|.:...|||:||..|:..||||||.|:|||||||
Zfish   889 EDFIKNLRGVDNGQDIPRDLLVGIYQRIQKWELRTNDDHVSQVQAVERVIVGKKPVLSLPHRRLV 953

  Fly   987 CYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMP 1051
            |.|:|||:||.|:.:|.|||||||||||||||:||||.||||||||:||.||||....|.:....
Zfish   954 CCCQLYEVPDPNRPQRSGVHQREVFLFNDLLVVTKIFQKKKTSVTYSFRQSFPLVEMQVHMFQNS 1018

  Fly  1052 NYPFCIQLSQKVDG---KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARN 1113
            .|...|:|:..:.|   |:||.|||.::.||.:|..||:|||:|:.:||..|:|:|||:||....
Zfish  1019 YYAHGIRLTSAMPGAERKVLIVFNAPSQQDRTRFTSDLRESIAEVQDMEKYRVESELEKQKGVMR 1083

  Fly  1114 RAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNS----QQLKRSALSNSLLDMHEQFG 1174
              ||......|.|..::.        ...:|.....|.|::    :.|||:|||:||.|:.:
Zfish  1084 --PGLMSGEVSSVGGMKT--------EAVNGTLGRPSLDDTYAAGEGLKRTALSSSLRDLSD--- 1135

  Fly  1175 NEKPQRRGSVGSLDS 1189
            ..|..||.|||||||
Zfish  1136 TGKRGRRNSVGSLDS 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	117/187 (63%)
		PH_IQSEC	981..1108	CDD:270128	75/129 (58%)
iqsec2a	XP_073766410.1	None