DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and iqsec3b

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_682922.4	Gene:	iqsec3b / 555340	ZFINID:	ZDB-GENE-050420-210	Length:	1051	Species:	Danio rerio

Alignment Length:	1070	Identity:	339/1070 - (31%)
Similarity:	472/1070 - (44%)	Gaps:	279/1070 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 GLGSGATSVIMQHQ------QQQQQQQNMHKKNSIRNGGDVLKRTRAQS-----------AYELS 316
            ||...:.|..:.||      :..:.:.:....:|:...|:..|..:...           .||||
Zfish   147 GLPRASESQTVLHQFCCPAPEAPEGESSTTCSSSVPAAGEEQKEEKRDDQPDVPPCSHPPEYELS 211

  Fly   317 QDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSL 380
            .||.:||||.||:|||| :.:|.||..||.|||.|.:.|.|..| ..:..|..:.|||.|....:
Zfish   212 PDLKQKQIEELEQKYGGPLISRRAACKIQTAFRQYQLSKNFQKI-RNSVLESGIPRRMSVRRVRV 275

  Fly   381 ---GLAEEGA------------SSSSAYGSATESQLTEQQQQQQAQQQQQPR---------VTIM 421
               |.:.|.|            :.|::....|.:.||..:.....|.|...|         .||.
Zfish   276 QRDGFSAERALMEGCSIMGIPLTHSTSLPVTTTTTLTHLEDTFSEQVQSLARSIDEALSSWSTIR 340

  Fly   422 AG---------PAGAASPGLSRTPPTRSLSMRERRQLDC-SPIPRSQSGASPASISSSTVSTSAL 476
            .|         |:|:...||...|.    |::|..|..| ..||||   ||...::...|:...
Zfish   341 DGEGEKSSAAPPSGSHPEGLLMDPS----SLQEATQSGCGESIPRS---ASKLMMAFRDVTVQI- 397

  Fly   477 ASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPY 541
                                              ..|:...:||...|::..    :|.:..|
Zfish   398 ----------------------------------DNHNFRLSSSMLESVSLG----NGVAKET-- 422

  Fly   542 YSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQ 606
            .|..||     ||      ..:|.|...:.|.         ||.|
Zfish   423 VSEPQI-----GG------QIAGQTTLSTAGD---------PEFP-------------------- 447

  Fly   607 TPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSS 671
             |||||                             ..|:.....:|.|.
Zfish   448 -PPPPS-----------------------------EEEKENQQPIGLDT---------------- 466

  Fly   672 QQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQH 736
                                |..|||:...|.. .||...|.....|..  :.|:.|||.:....
Zfish   467 --------------------VTTGAGLEGKQTN-QVAPEIAENSSDPIS--SSSTSTSACETMIL 508

  Fly   737 EQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGV 801
            ...:...|.......:..:|         |||.||:||||||..|:|||.:||.|||:.:|..||
Zfish   509 SLPRPHCQNTPCGTLSTDIA---------RKRLYRIGLNLFNVNPDKGIQFLISRGFIPDTAIGV 564

  Fly   802 ARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKI 866
            |.||:.|||||||||||:|||.:.|||..||.|...|:|.|..::|.|||||||:.|:.|||||:
Zfish   565 AHFLLQRKGLSRQMIGEFLGNSKRQFNRDVLDCVVDEMDFSMLELDEALRKFQAHVRVQGEAQKV 629

  Fly   867 ERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGI 931
            |||:|.||||||.||.|:|.:..:.||||:|||||::||||:::||:||||:|.:||||:||||:
Zfish   630 ERLIEAFSQRYCMCNPDVVQQFHNPDTIFILAFAIVLLNTDMYSPNIKPERKMLLEDFIRNLRGV 694

  Fly   932 DDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPD 996
            ||..||.::||.|||:|::..|.:...||||.|.:|:.:|:|.|..|::|||||||..||||:.|
Zfish   695 DDGADIPREMLAGIYERIQQRELRSNEDHVTYVTRVEQSILGMKTILSVPHRRLVCCSRLYEVTD 759

  Fly   997 VNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQL-- 1059
            |||.::...|||||||||||:||.|:..||||:.||||..:..|.|....|.:...||..|.:
Zfish   760 VNKPQKQASHQREVFLFNDLIVILKLCPKKKTAATYTFCKAMGLLGMQFHLFENEYYPHGITILS 824

  Fly  1060 ---SQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAEN 1121
               |:|   |.:::|.:::..:..||.|||:|||:|:.|||.:|||.|||||:..||:.     |
Zfish   825 PFSSEK---KQVVSFCSQSADELLKFIEDLRESIAEVAEMEQIRIEWELERQQVVRNQT-----N 881

  Fly  1122 RDSGVADVEVCPCPYQQGSQASGEQAPNSADNS-------QQLKRSALSNSLLDMHEQFGNEKPQ 1179
            ::....|:...|      |.|||:.....|.::       .:|:...||:.|.....|      |
Zfish   882 KNGTQLDIHAGP------SSASGDDFYEKAGSNTVEVSIHNRLQTYQLSSPLAPPSAQ------Q 934

  Fly  1180 RRGSVGS--LDSGMSISFQSTTTSSASRENAAAIAAAANAAAAAKMRFNMPPT-----AAIATPS 1237
            |...:.|  .||.::|| ..|............:.:|......|.:..|  |.     :|::||:
Zfish   935 RLAVLPSPAPDSALTIS-PDTLIQCQQIVKVIVVDSAGRGHVEAFLSHN--PAHRLIQSAVSTPT 996

  Fly  1238 NVYAAPGMQAYTHANFVQQSQAAYMLQQQQ 1267
                              :|:.|...||||
Zfish   997 ------------------RSREAGKQQQQQ 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	115/187 (61%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	65/131 (50%)
iqsec3b	XP_682922.4	Sec7	529..717	CDD:279680	115/187 (61%)
iqsec3b	XP_682922.4	IQ_SEC7_PH	742..868	CDD:293062	61/128 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582808
Domainoid	1	1.000	265	1.000	Domainoid score	I1852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360558at33208
OrthoFinder	1	1.000	-	-		FOG0002052
OrthoInspector	1	1.000	-	-		otm25632
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950