DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Efa6

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001163691.2	Gene:	Efa6 / 42665	FlyBaseID:	FBgn0051158	Length:	1601	Species:	Drosophila melanogaster

Alignment Length:	1547	Identity:	307/1547 - (19%)
Similarity:	496/1547 - (32%)	Gaps:	544/1547 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PGPVSLPLPLSINMPHHHVHAMP----YNVDELLRENNALHAKIKELSLERD---RLLCEVSNLR 110
            |.|.|.| |.....|....:.|.    .|:....:.:|.|.|:.|::...||   ||:    |.|
  Fly   310 PEPNSAP-PQPAKAPRFEAYMMTGDLILNLSRTPQTSNPLPAQAKKIDSLRDSPSRLV----NPR 369

  Fly   111 LELDMSELKRLPVDLDDNFPQKSLERSGSTQYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYA 175
            :.                                 ||..|.::..|:.|.|.||.         :
  Fly   370 IN---------------------------------GALAPRASGESSPTSSSSVD---------S 392

  Fly   176 PGAHSSSAAINYPAQQHPQMVYQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHYMQVTATGG---- 236
            | .::||.::...|:     :.|.|      ||||||..||||........:..:.:.|..
  Fly   393 P-TNTSSDSVKREAK-----LLQKQ------QQQQQQTYQQQQQRDSINNSYNRKDSLTNDTLLM 445

  Fly   237 ---------GQYHHHHMLHGHGHHAHHHGGAVVIAGSGVGTGLGSGATSVIMQHQQQQQQQQNMH 292
                     |:|                                     |:.:..:||:|:|...
  Fly   446 CEELEPDEEGEY-------------------------------------VLEEDNKQQRQRQQQQ 473

  Fly   293 KKNSIRNGGDVLKRTRAQSAYEL--SQDLLEKQIELLERKYGGVRARNAAVTIQRAFRHYMMVKK 355
            :....:|          |..||.  ::|.||:|.|:.|.:             :....||.:...
  Fly   474 RYRQQQN----------QQRYEYYQNEDELEEQEEVEEER-------------EEDQTHYDITNI 515

  Fly   356 FASITAMAKAEKRLSRRMVVT------------ASSLGLAEEGASSSSAYGSATESQLTEQQQQQ 408
            ....:.:.:.:...|.|..:.            .:..|  :|..|::|....:.:.:|...:|:.
  Fly   516 ETYQSGVGRGDDDDSDRQCLVDDDDDDDAYDDEENDAG--DEDYSTNSLGSGSAKQRLRALKQRT 578

  Fly   409 QAQQQQQPRVTI-MAGPAGAASP-----------GLSRTP---PTRSLSM------RERRQLDCS 452
            ..:|||:.|..: .||.:|:.|.           ||..|.   ||..:|:      :|    ..:
  Fly   579 ATRQQQRNRDAVDCAGRSGSGSSSTTVKSEAGGLGLDETSFSVPTSPISLSTPLIDKE----TAN 639

  Fly   453 PIPRSQSGASPASISSSTVSTSALASHPH----VNLLHAA-------EPHYYNAQALPQGAAYYT 506
            .:|.|...:|....|||.....|:....|    |....||       |.|....|.  :|.|...
  Fly   640 SVPTSPEPSSLVPESSSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQR--EGIAAVI 702

  Fly   507 SYHGSPHDL--SYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSG 569
                 |.|:  ...||.:|.|:....:....|..|...:.:.:......|..|...|.|.|:.|.
  Fly   703 -----PIDIDEDVNSSLNTLLDTRQDSEDSQSMATVIVNNSSLASNNNEGEQTDNRSSSSSSNSS 762

  Fly   570 SGGS-GSGSSKKVPPEVPKRTSS-ITA-------------------------------------- 594
            ...: .|.:.:....|....|:: |||
  Fly   763 DNNNCSSNTGEPATSETATATATIITATSTRTMNCSSKLNYILCKKASDRDRIVWTYNAPLQPHQ 827

  Fly   595 --------QQQTQLLLLQRQTPPPPSLLRTNGL---------------------CKTAENGSLTS 630
                    |||.|....|:|......|.:...|                     .::..|...:|
  Fly   828 LAALQRQQQQQEQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQQSHSNSHSSS 892

  Fly   631 VQSS------GSDSSVTSAERNLNSDLGS-------DRSNSPHTWKRGTALNSSQQFSTHSADSA 682
            :.||      ||.:|.||...::.|..||       ..||.|        :.:.||......:..
  Fly   893 ISSSPQHSAVGSPASPTSVSSSVMSSSGSKGALGLGSSSNGP--------MAAVQQQQLREREQG 949

  Fly   683 GAV--------------------SGGGVGVAGGAGVYAAQMQA--------------AVAAATAA 713
            |.|                    :|||.|:.||.....:..:|              .:::....
  Fly   950 GQVAQPPSGIPGLLSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDIL 1014

  Fly   714 GGM---PPADDHA--ISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKR----- 768
            |||   .|:|..:  :.|..:|.|.:|.:||...|||.|            :..|..|.|
  Fly  1015 GGMVLSDPSDSDSTILVSDAAAHQRQQLKQQLRAQQQQQ------------RERERDRDRDREQS 1067

  Fly   769 QYRV------------GLNLFNKKPEKGITYL-------IRRGFLENTPQ--------------- 799
            :::|            |.|..|.:.|:.:..|       :..|..:.:|.
  Fly  1068 EHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVESLHSYH 1132

  Fly   800 ------------GVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRK 852
                        .:|:.|.:..|..:..:..:|.. .|.|:.||...:........:.:|.|||:
  Fly  1133 YSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSK-NNDFSRAVADEYLKHFTFEKKSLDQALRE 1196

  Fly   853 FQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPER 917
            |...|.:.||.|:.||::..||:|:.:||.   |...|.|.:..|..||::||||||..|:  .|
  Fly  1197 FLQQFSLSGETQERERVLVHFSKRFLDCNP---GTFNSQDAVHTLTCAIMLLNTDLHGQNI--NR 1256

  Fly   918 RMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQAT------IVGKKP 976
            :|...:|:.||..::|..:..||:|..:|..:|:...:...|.....::.|..      .||..|
  Fly  1257 KMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEEAGDLQQQRANNSALGNVGLNP 1321

  Fly   977 NLALPH------------RRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTS 1029
            .|..|.            .|..||       |.:.|:.|                   |.|:...
  Fly  1322 FLDPPELATAVEYKKGYVMRKCCY-------DSSFKKTP-------------------FGKRSWK 1360

  Fly  1030 VTY-TFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNA-RNEHDRCKFAEDL--KESI 1090
            :.| |.|:       :|..|....:.|  :.||..|.    ..|| |..|.....|.|.  |:.:
  Fly  1361 MFYCTLRD-------LVLYLHKDEHGF--RKSQMSDN----LHNAIRIHHALATKANDYTKKQHV 1412

  Fly  1091 SEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVE-VC---PCPYQQGSQASGEQAPNSA 1151
            ..:...:    :||...|.|       :::...|.|..:. ||   ..|..:|...|.::.....
  Fly  1413 FRLQTAD----QAEYLFQTS-------DSKELQSWVETINYVCAAISAPPLEGGVGSQKRFQRPL 1466

  Fly  1152 DNSQQLKRSALSNSLLDMHE----QFGNE-KPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAI 1211
            ..|:|.|  .:....||.||    |...| ...::|.:.|  .|:::.......|
  Fly  1467 LPSKQSK--LMLKEQLDSHEVQLAQLDQELNEHKKGPIPS--KGLALQNYKEKES---------- 1517

  Fly  1212 AAAANAAAAAKMRFNMPPTAAIATPSNVYAAPGMQAY-THANFVQQSQAAYMLQQQQMLQQQAQM 1275
                                        |....::.| |:.:.:    :|.||..||.|:.|||.
  Fly  1518 ----------------------------YLQYELRRYRTYVSIL----SAKMLADQQQLELQAQQ 1550

  Fly  1276 QAQAQAQAQA---------------QAQAQAQAQAQAQAQPLTGRIPGRERK 1312
            .:.|..:.:|               |:..|...|.:.|.|..|.|   :|:|
  Fly  1551 PSPASHEEEADTFPVGTTACTPPTPQSINQKDQQKEQQQQQPTNR---KEKK 1599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	58/238 (24%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	27/142 (19%)
Efa6	NP_001163691.2	PDZ_signaling	7..85	CDD:238492
		PHA03269	225..>344	CDD:165527	8/34 (24%)
		Sec7	1124..1293	CDD:238100	48/174 (28%)
		PH_EFA6	1330..1452	CDD:270107	33/171 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840