DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and step

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	184/795 - (23%)
Similarity:	306/795 - (38%)	Gaps:	210/795 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 RERRQLDCSP-------IPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQG 501
            |:.:...|||       :.|.|    |...|...:||:.:.....|:|      .::.::: |:.
  Fly    20 RQPKNKKCSPGLGGSESVGRKQ----PLQRSCLDLSTTRVGCDGCVSL------EFFQSES-PES 73

  Fly   502 AAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTP-----S 561
            ....::::.:..::|.|...|                    :...:..|..|..::|:.     |
  Fly    74 RRSNSTFYVNTQNVSSAVFKD--------------------NRQPLLERGSGSDSSPSSVCVRCS 118

  Fly   562 CSGSTGSGSGG-----SGSGSSKKV---PPEVPKRTS--SITAQQQTQLLLLQRQTPPP--PSLL 614
            |:..|.||...     :...|..|:   ||..|:..|  ..|:.....:..|...:|||  |:|
  Fly   119 CNSITKSGDRNETPTMATPKSDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTL- 182

  Fly   615 RTNGLCKTAENGSLTSVQSSGSDSSVTSAER----NLNSDLGSDRSNSPHTWKRGTA-------- 667
                        |..:|..|...:.||..:|    ..|::|.|.|:...||....|.
  Fly   183 ------------STQTVNCSDVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRP 235

  Fly   668 ----LNSSQQFSTHSA--DSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISS 726
                ||.:.:.....:  .|.....|..:.|....|.....|:|...:..:....|..||.....
  Fly   236 VELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADPCSKNSLPPPPYIDDMRFID 300

  Fly   727 HTSAAQYE------------------QHEQQQHEQQQLQAAAAAAGVAQNY-------------- 759
            .:|.:|.|                  .::.::..||.....:....:.:||
  Fly   301 DSSNSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRR 365

  Fly   760 -------KMSETI----------------RKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGV 801
                   ::.|.:                :.:|..:|...||..|:|||.||:....|.:.||.|
  Fly   366 PSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDV 430

  Fly   802 ARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKI 866
            |.||...:||::..||:|||. :|.||..||..|....|.:...:..|||:|...||:|||||||
  Fly   431 AHFLYKGEGLNKTAIGDYLGE-KNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKI 494

  Fly   867 ERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGI 931
            :|:||.|:||||:.|.||   ..::||.:||:||||||||.||.|::|.  :..|:.||...|||
  Fly   495 DRMMETFAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLHNPSVKD--KPTVDQFISMNRGI 554

  Fly   932 DDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPD 996
            ::..|:.:.:|..:|:.::::.||...|....:|                        ..:..||
  Fly   555 NNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLM------------------------HTFFNPD 595

  Fly   997 VNKKE--------RPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNY 1053
               ||        |....:|..|:.||..:....::..|..     |...||....|..:...:.
  Fly   596 ---KEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEP-----RGIIPLENISVREIHDRSK 652

  Fly  1054 PFCIQL-----------------SQKVDGK-ILITFNARNEHDRCKFAEDLKESISEMDEMESLR 1100
            |.|.:|                 .:.|:|| .:...:|..|.|:.::.:.|.:|||.....:.|
  Fly   653 PHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDIL- 716

  Fly  1101 IEAELERQKSARNRA 1115
                ::|:|.|.:::
  Fly   717 ----VQRKKKALSKS 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	80/187 (43%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	28/152 (18%)
step	NP_001036375.2	Sec7	397..577	CDD:279680	80/185 (43%)
		PH_GRP1-like	592..710	CDD:269954	27/125 (22%)
		PH	596..708	CDD:278594	23/116 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840